Proton-pump inhibitor proton-pump.com

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Cefamandole Sodium Salt is a second-generation broad-spectrum cephalosporin antibiotic.|Product information|CAS Number: 30034-03-8|Molecular Weight: 484.{{Ketoconazole} site|{Ketoconazole} Anti-infection|{Ketoconazole} Protocol|{Ketoconazole} References|{Ketoconazole} manufacturer|{Ketoconazole} Autophagy} 48|Formula: C18H17N6NaO5S2|Chemical Name: sodium (6R,7R)-7-[(2R)-2-hydroxy-2-phenylacetamido]-3-{[(1-methyl-1H-1,2,3,4-tetrazol-5-yl)sulfanyl]methyl}-8-oxo-5-thia-1-azabicyclo[4.{{Tirofiban} MedChemExpress|{Tirofiban} Integrin|{Tirofiban} Technical Information|{Tirofiban} References|{Tirofiban} manufacturer|{Tirofiban} Cancer} 2.PMID:23865629 0]oct-2-ene-2-carboxylate|Smiles: [Na+].CN1N=NN=C1SCC1CS[C@@H]2[C@H](NC(=O)[C@H](O)C3=CC=CC=C3)C(=O)N2C=1C([O-])=O|InChiKey: OJMNTWPPFNMOCJ-CFOLLTDRSA-M|InChi: InChI=1S/C18H18N6O5S2.Na/c1-23-18(20-21-22-23)31-8-10-7-30-16-11(15(27)24(16)12(10)17(28)29)19-14(26)13(25)9-5-3-2-4-6-9;/h2-6,11,13,16,25H,7-8H2,1H3,(H,19,26)(H,28,29);/q;+1/p-1/t11-,13-,16-;/m1./s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : 50 mg/mL (103.20 mM; Need ultrasonic). H2O : 33.33 mg/mL (68.80 mM; Need ultrasonic).|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|

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Arctiin is a lignan found in many plants of the Asteraceae family, particularly the greater burdock (Arctium lappa) and Centaurea imperialis, and in Trachelospermum asiaticum, Saussurea heteromalla.{{Trastuzumab (anti-HER2)} medchemexpress|{Trastuzumab (anti-HER2)} JAK/STAT Signaling|{Trastuzumab (anti-HER2)} NF-κB|{Trastuzumab (anti-HER2)} Biological Activity|{Trastuzumab (anti-HER2)} Formula|{Trastuzumab (anti-HER2)} supplier} , and Forsythia viridissima. It is the glucoside of arctigenin. Arctiin and arctigenin have shown anticancer effects.|Product information|CAS Number: 20362-31-6|Molecular Weight: 534.55|Formula: C27H34O11|Chemical Name: (3R,4R)-4-[(3,4-dimethoxyphenyl)methyl]-3-[(3-methoxy-4-{[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}phenyl)methyl]oxolan-2-one|Smiles: COC1=CC=C(C[C@H]2COC(=O)[C@@H]2CC2=CC(OC)=C(C=C2)O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)C=C1OC|InChiKey: XOJVHLIYNSOZOO-SWOBOCGESA-N|InChi: InChI=1S/C27H34O11/c1-33-18-6-4-14(10-20(18)34-2)8-16-13-36-26(32)17(16)9-15-5-7-19(21(11-15)35-3)37-27-25(31)24(30)23(29)22(12-28)38-27/h4-7,10-11,16-17,22-25,27-31H,8-9,12-13H2,1-3H3/t16-,17+,22+,23+,24-,25+,27+/m0/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.PMID:24487575 |Shelf Life: ≥360 days if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|

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TIC10 isomer is an isomer and the “inactive version” of TIC10. TIC-10 isomer was introduced to the research community since it was structurally wrong-assigned as the bioactive TIC-10 during early stage development of TIC-10 (now called ONC-201).{{Atropine} medchemexpress|{Atropine} Metabolic Enzyme/Protease|{Atropine} Technical Information|{Atropine} Description|{Atropine} supplier|{Atropine} Epigenetic Reader Domain} TIC-10 isomer was found to be inactive, which did not reduce the viability of cancer cells.PMID:23291014 TIC-10 isomer may be used as a reference compound to compare with ONC-201.|Product information|CAS Number: 41276-02-2|Molecular Weight: 386.49|Formula: C24H26N4O|Chemical Name: 11-benzyl-2-[(2-methylphenyl)methyl]-2,4,7,11-tetraazatricyclo[7.4.0.0³,⁷]trideca-1(9),3-dien-8-one|Smiles: CC1=CC=CC=C1CN1C2=NCCN2C(=O)C2CN(CC3C=CC=CC=3)CCC1=2|InChiKey: RSAQARAFWMUYLL-UHFFFAOYSA-N|InChi: InChI=1S/C24H26N4O/c1-18-7-5-6-10-20(18)16-28-22-11-13-26(15-19-8-3-2-4-9-19)17-21(22)23(29)27-14-12-25-24(27)28/h2-10H,11-17H2,1H3|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥360 days if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|

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c-Met inhibitor 1 is an inhibitor of the c-Met receptor signaling pathway useful for the treatment of cancer including gastric, glioblastoma, and pancreatic cancer. IC50 value:Target: c-MetMore details please refer to Patent WO 2012015677 A1.|Product information|CAS Number: 1357072-61-7|Molecular Weight: 362.41|Formula: C17H14N8S|Chemical Name: 2-methyl-5-{[6-(1-methyl-1H-pyrazol-4-yl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl]sulfanyl}-2H-indazole|Smiles: CN1C=C2C=C(C=CC2=N1)SC1=NN=C2C=CC(=NN21)C1C=NN(C)C=1|InChiKey: JYXHZDNTBJUJNH-UHFFFAOYSA-N|InChi: InChI=1S/C17H14N8S/c1-23-10-12(8-18-23)15-5-6-16-19-20-17(25(16)22-15)26-13-3-4-14-11(7-13)9-24(2)21-14/h3-10H,1-2H3|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Xevinapant} MedChemExpress|{Xevinapant} IAP|{Xevinapant} Purity & Documentation|{Xevinapant} Formula|{Xevinapant} custom synthesis|{Xevinapant} Epigenetic Reader Domain} |Shelf Life: ≥360 days if stored properly.PMID:35850484 |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|

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Dasabuvir, also known as ABT-333, is a non-nucleoside polymerase inhibitor currently under clinical trials for the treatment of Hepatitis C. In the United States, it is approved by the Food and Drug Administration for use in combination with ombitasvir, paritaprevir, and ritonavir in the product Viekira Pak. Dasabuvir acts as a NS5B (an RNA-directed RNA polymerase) inhibitor.|Product information|CAS Number: 1132935-63-7|Molecular Weight: 493.57|Formula: C26H27N3O5S|Synonym:|Dasabuvir|ABT333|ABT 333|Chemical Name: N-{6-[3-tert-butyl-5-(2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)-2-methoxyphenyl]naphthalen-2-yl}methanesulfonamide|Smiles: COC1C(=CC(=CC=1C(C)(C)C)N1C=CC(=O)NC1=O)C1=CC2=CC=C(C=C2C=C1)NS(C)(=O)=O|InChiKey: NBRBXGKOEOGLOI-UHFFFAOYSA-N|InChi: InChI=1S/C26H27N3O5S/c1-26(2,3)22-15-20(29-11-10-23(30)27-25(29)31)14-21(24(22)34-4)18-7-6-17-13-19(28-35(5,32)33)9-8-16(17)12-18/h6-15,28H,1-5H3,(H,27,30,31)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: Soluble in DMSO|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|ABT-333 (Dasabuvir) is at least 7, 000-fold selective for the inhibition of HCV genotype 1 polymerases over human/mammalian polymerases. ABT-333 (Dasabuvir) inhibits the polymerase enzymatic activity of genotype 1 laboratory strain enzymes (H77, BK, N, and Con1 strains), as well as enzymes produced from polymerase genes from HCV genotype 1-infected subjects, with IC50s between 2.2 and 10.7 nM. ABT-333 inhibits replication of HCV subgenomic replicons in cell culture assays, with EC50 values of 7.{{OPC 4392} site|{OPC 4392} Dopamine Receptor|{OPC 4392} TGF-beta/Smad|{OPC 4392} Protocol|{OPC 4392} In Vivo|{OPC 4392} supplier} 7 and 1.{{Mecillinam} medchemexpress|{Mecillinam} Antibiotic|{Mecillinam} Epigenetics|{Mecillinam} Protocol|{Mecillinam} References|{Mecillinam} supplier} 8 nM against genotype 1a (H77) and 1b (Con1), respectively.PMID:23756629 In the presence of 40% human plasma, there is a 12- to 13-fold decrease in inhibitory potency, yielding EC50s of 99 and 21 nM for HCV genotype 1a (H77) and 1b (Con1) replicons, respectively.|In Vivo:|The recombinant HCV polymerases used in this study contain the first 570 amino acids of the 591-amino acid native protein sequence, with a six-histidine tag at the N terminus to facilitate purification by affinity chromatography. Briefly, ABT-333 (Dasabuvir) is incubated with 5 to 50 nM polymerase for 15 min at room temperature, follow by the addition of nucleoside triphosphates (NTPs) and [3H]UTP for 3 h at 30°C. After termination of the reaction, the precipitated RNA is captured by filtration through a GF/B filter. The amount of incorporated [3H]UTP is measured by scintillation counting with a Wallac 1450 MicroBeta counter. The percent inhibition is calculated from the initial rates of inhibited reactions relative to that of the uninhibited control reaction. The mean 50% inhibitory concentration (IC50) and the standard error of the mean (SEM) are calculated via nonlinear regression.|References:|Kati W, et al. In vitro activity and resistance profile of dasabuvir, a nonnucleoside hepatitis C virus polymerase inhibitor. Antimicrob Agents Chemother. 2015 Mar;59(3):1505-11.Products are for research use only. Not for human use.|

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Enoxacin is an oral broad-spectrum fluoroquinolone antibacterial agent used in the treatment of urinary tract infections and gonorrhea. Enoxacin is a broad-spectrum antibacterial agent that is structurally related to nalidixic acid. It acts on DNA gyrase.{{Baclofen} medchemexpress|{Baclofen} Membrane Transporter/Ion Channel|{Baclofen} Protocol|{Baclofen} In stock|{Baclofen} manufacturer|{Baclofen} Epigenetics} Insomnia is a common adverse effect. Recently, enoxacin has been shown recently that it may have cancer inhibiting effect.|Product information|CAS Number: 74011-58-8|Molecular Weight: 320.32|Formula: C15H17FN4O3|Synonym:|Penetrex|AT 2266|CI 919|Chemical Name: 1-ethyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid|Smiles: CCN1C=C(C(O)=O)C(=O)C2=CC(F)=C(N=C12)N1CCNCC1|InChiKey: IDYZIJYBMGIQMJ-UHFFFAOYSA-N|InChi: InChI=1S/C15H17FN4O3/c1-2-19-8-10(15(22)23)12(21)9-7-11(16)14(18-13(9)19)20-5-3-17-4-6-20/h7-8,17H,2-6H2,1H3,(H,22,23)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{OPC 4392} site|{OPC 4392} GPCR/G Protein|{OPC 4392} TGF-beta/Smad|{OPC 4392} Protocol|{OPC 4392} Purity|{OPC 4392} supplier} |Shelf Life: ≥12 months if stored properly.PMID:23291014 |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|

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Dynarrestin is a aminothiazole inhibitor of cytoplasmic dyneins 1 and 2. Dynarrestin rapidly and reversibly inhibits dynein 1-driven microtubule gliding in vitro plus a range of dynein 1- and 2-dependent processes in cells without affecting ATP hydrolysis and interfering with ciliogenesis. Dynarrestin suppresses hedgehog (Hh)-dependent proliferation of neuronal precursors and tumor cells.|Product information|CAS Number: 2222768-84-3|Molecular Weight: 431.50|Formula: C22H23F2N3O2S|Chemical Name: ethyl 4-[4-(diethylamino)phenyl]-2-[(2,4-difluorophenyl)amino]-1,3-thiazole-5-carboxylate|Smiles: CCOC(=O)C1SC(NC2=CC=C(F)C=C2F)=NC=1C1C=CC(=CC=1)N(CC)CC|InChiKey: UZNNDDDSGCMQOQ-UHFFFAOYSA-N|InChi: InChI=1S/C22H23F2N3O2S/c1-4-27(5-2)16-10-7-14(8-11-16)19-20(21(28)29-6-3)30-22(26-19)25-18-12-9-15(23)13-17(18)24/h7-13H,4-6H2,1-3H3,(H,25,26)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : 83.33 mg/mL (193.12 mM; Need ultrasonic).|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|

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SNIPER(ER)-110 consists of a cIAP1 ligand and an estrogen ligand, connected by a linker.{{Sulfapyridine} MedChemExpress|{Sulfapyridine} Antibiotic|{Sulfapyridine} Biological Activity|{Sulfapyridine} Data Sheet|{Sulfapyridine} supplier|{Sulfapyridine} Epigenetics} SNIPER(ER)-51 induces estrogen receptor (ER) protein degradation with DC50s of Product information|CAS Number: 2241690-03-7|Molecular Weight: 1122.PMID:23892746 39|Formula: C66H83N5O11|Chemical Name: (2S,4S)-1-[(2S)-2-cyclohexyl-2-[(2S)-2-(methylamino)propanamido]acetyl]-4-(3-{2-[2-(2-{[(2-{4-[(1Z)-1-(4-hydroxyphenyl)-2-phenylbut-1-en-1-yl]phenoxy}ethyl)(methyl)carbamoyl]methoxy}ethoxy)ethoxy]ethoxy}phenoxy)-N-[(1R)-1,2,3,4-tetrahydronaphthalen-1-yl]pyrrolidine-2-carboxamide|Smiles: CN(CCOC1C=CC(=CC=1)/C(=C(/CC)\C1C=CC=CC=1)/C1C=CC(O)=CC=1)C(=O)COCCOCCOCCOC1=CC(=CC=C1)O[C@H]1C[C@@H](C(=O)N[C@@H]2CCCC3=CC=CC=C32)N(C1)C(=O)[C@@H](NC(=O)[C@H](C)NC)C1CCCCC1|InChiKey: DXLPZZKVYXMXOP-UXACQRMVSA-N|InChi: InChI=1S/C66H83N5O11/c1-5-57(47-16-8-6-9-17-47)62(49-26-30-52(72)31-27-49)50-28-32-53(33-29-50)80-35-34-70(4)61(73)45-79-39-38-77-36-37-78-40-41-81-54-22-15-23-55(42-54)82-56-43-60(65(75)68-59-25-14-21-48-18-12-13-24-58(48)59)71(44-56)66(76)63(51-19-10-7-11-20-51)69-64(74)46(2)67-3/h6,8-9,12-13,15-18,22-24,26-33,42,46,51,56,59-60,63,67,72H,5,7,10-11,14,19-21,25,34-41,43-45H2,1-4H3,(H,68,75)(H,69,74)/b62-57-/t46-,56-,59+,60-,63-/m0/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|

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Creatinine-D3 (NSC13123-D3) is a deuterium labeled Creatinine. Creatinine is a break-down product of creatine phosphate in muscle.|Product information|CAS Number: 143827-20-7|Molecular Weight: 116.14|Formula: C4H7N3O|Chemical Name: 2-amino-1-(²H₃)methyl-4,5-dihydro-1H-imidazol-4-one|Smiles: [2H]C([2H])([2H])N1CC(=O)N=C1N|InChiKey: DDRJAANPRJIHGJ-FIBGUPNXSA-N|InChi: InChI=1S/C4H7N3O/c1-7-2-3(8)6-4(7)5/h2H2,1H3,(H2,5,6,8)/i1D3|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Rucaparib} MedChemExpress|{Rucaparib} Cell Cycle/DNA Damage|{Rucaparib} Protocol|{Rucaparib} Data Sheet|{Rucaparib} custom synthesis|{Rucaparib} Autophagy} |Shelf Life: ≥12 months if stored properly.PMID:23558135 |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|

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Cd(II) protoporphyrin IX is a protoporphyrin IX. Protoporphyrin IX is a heterocyclic organic compound, which consists of four pyrrole rings, and is the final intermediate in the heme biosynthetic pathway.|Product information|CAS Number: 80216-25-7|Molecular Weight: 673.05|Formula: C34H32CdN4O4|Chemical Name: 10,14-bis(2-carboxyethyl)-4,19-diethenyl-5,9,15,20-tetramethyl-21,22,23,24-tetraazapentacyclo[16.2.1.1³,⁶.1⁸,¹¹.1¹³,¹⁶]tetracosa-1(20),2,4,6,8,10,12,14,16,18-decaene-21,22,23,24-tetraide cadmium|Smiles: [Cd].CC1C(C=C)=C2C=C3[N-]C(=CC4[N-]C(C=C5[N-]C(=CC=1[N-]2)C(C=C)=C5C)=C(C)C=4CCC(O)=O)C(CCC(O)=O)=C3C |c:6,9,14,17||InChiKey: MPXUUHBENXDJJI-RGGAHWMASA-N|InChi: InChI=1S/C34H32N4O4.{{Purmorphamine} medchemexpress|{Purmorphamine} Smo|{Purmorphamine} Epigenetics|{Purmorphamine} Technical Information|{Purmorphamine} In Vitro|{Purmorphamine} supplier} Cd/c1-7-21-17(3)25-13-26-19(5)23(9-11-33(39)40)31(37-26)16-32-24(10-12-34(41)42)20(6)28(38-32)15-30-22(8-2)18(4)27(36-30)14-29(21)35-25;/h7-8,13-16H,1-2,9-12H2,3-6H3,(H,39,40)(H,41,42);/q-4;/b25-13-,26-13-,27-14-,28-15-,29-14-,30-15-,31-16-,32-16-;|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Afatinib dimaleate} site|{Afatinib dimaleate} Apoptosis|{Afatinib dimaleate} Immunology/Inflammation|{Afatinib dimaleate} Technical Information|{Afatinib dimaleate} Formula|{Afatinib dimaleate} custom synthesis} |Shelf Life: ≥12 months if stored properly.PMID:25046520 |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|

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ERD03 is a potent disruptor of the EXOSC3-RNA interaction, with a Kd of 17±7 μM . ERD03 induces PCH1B-like phenotype in zebrafish embryo and can be used for neurological disorder disease research.|Product information|CAS Number: 1377897-01-2|Molecular Weight: 339.43|Formula: C21H25NO3|Chemical Name: (4-hydroxy-3, 4-dihydro-1H-isoquinolin-2-yl)-[3-(3-hydroxy-3-methylbutyl)phenyl]methanone|Smiles: CC(C)(O)CCC1C=CC=C(C=1)C(=O)N1CC2=CC=CC=C2C(O)C1|InChiKey: HYVUFYJZMRRTOP-UHFFFAOYSA-N|InChi: InChI=1S/C21H25NO3/c1-21(2,25)11-10-15-6-5-8-16(12-15)20(24)22-13-17-7-3-4-9-18(17)19(23)14-22/h3-9,12,19,23,25H,10-11,13-14H2,1-2H3|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Avapritinib} medchemexpress|{Avapritinib} c-Kit|{Avapritinib} Purity & Documentation|{Avapritinib} In Vitro|{Avapritinib} custom synthesis|{Avapritinib} Epigenetics} |Shelf Life: ≥12 months if stored properly.{{SARS-CoV-2 S2 Protein (HEK293, His)} web|{SARS-CoV-2 S2 Protein (HEK293, His)} Protocol|{SARS-CoV-2 S2 Protein (HEK293, His)} Purity|{SARS-CoV-2 S2 Protein (HEK293, His)} manufacturer|{SARS-CoV-2 S2 Protein (HEK293, His)} Autophagy} |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.PMID:28038441 |Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|ERD03 inhibits the binding of G-rich RNA and EXOSC3 with ~18% inhibition at 50 μM. ERD03 (50 μM; 5 days) causes significant spinal curvature and recapitulates PCH1B phenotype in development in zebrafish embryos. ERD03 (50 μM) induces a ~6-fold upregulation of ataxin1b mRNA and results in a minor accumulation of ataxin1a mRNA in embryos. ERD03 induces an atrophy of the zebrafish cerebellum and results in zebrafish cerebella half the size of control brains in DMSO.|Products are for research use only. Not for human use.|

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Naftopidil dihydrochloride (KT-611 dihydrochloride) is a selective alpha1-adrenoceptor antagonist, with Kis of 3.7 nM, 20 nM and 1.2 nM for the cloned human α1a-, α1b- and α1d-adrenoceptor subtypes, respectively. Naftopidil dihydrochloride has antiproliferative effects. Naftopidil dihydrochloride can be used for the research of prostate hyperplasia.|Product information|CAS Number: 57149-08-3|Molecular Weight: 465.41|Formula: C24H30Cl2N2O3|Chemical Name: 1-[4-(2-methoxyphenyl)piperazin-1-yl]-3-(naphthalen-1-yloxy)propan-2-ol dihydrochloride|Smiles: Cl.Cl.COC1=CC=CC=C1N1CCN(CC(O)COC2=CC=CC3=CC=CC=C32)CC1|InChiKey: HZVCEQMJXMUXJF-UHFFFAOYSA-N|InChi: InChI=1S/C24H28N2O3.{{Miconazole} medchemexpress|{Miconazole} Antibiotic|{Miconazole} Protocol|{Miconazole} Purity|{Miconazole} supplier|{Miconazole} Autophagy} 2ClH/c1-28-24-11-5-4-10-22(24)26-15-13-25(14-16-26)17-20(27)18-29-23-12-6-8-19-7-2-3-9-21(19)23;;/h2-12,20,27H,13-18H2,1H3;2*1H|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Daratumumab} site|{Daratumumab} CD38|{Daratumumab} Protocol|{Daratumumab} Formula|{Daratumumab} supplier|{Daratumumab} Cancer} |Shelf Life: ≥12 months if stored properly.PMID:25016614 |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|Naftopidil dihydrochloride suppresses human prostate tumor growth by altering interactions between tumor cells and stroma. Naftopidil dihydrochloride (10 μM for PCa cells, 0.1-10 μM for PrSC; 3 days) shows growth inhibitory effects on PCa cells and PrSC. Naftopidil dihydrochloride (50 μM for E9 cells, 25 μM for PrSC; 48 hours) increases the level of cell-cycle regulatory protein p27 in E9 cells, but not PrSC.|In Vivo:|Naftopidil dihydrochloride (10 mg/kg; p.o; daily; for 28 days) decreases microvessel density (MVD) in E9+PrSC tumors mice model.|Products are for research use only. Not for human use.|

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Syringetin-3-O-glucosid (Syringetin 3-O-β-D-glucoside), a flavonol glycoside, shows relatively weak DPPH and ABTS radical scavenging activity.|Product information|CAS Number: 40039-49-4|Molecular Weight: 508.43|Formula: C23H24O13|Chemical Name: 5,7-dihydroxy-2-(4-hydroxy-3,5-dimethoxyphenyl)-3-{[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-4H-chromen-4-one|Smiles: COC1=CC(=CC(OC)=C1O)C1OC2=CC(O)=CC(O)=C2C(=O)C=1O[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O|InChiKey: JMFWYRWPJVEZPV-AVGVHVDKSA-N|InChi: InChI=1S/C23H24O13/c1-32-12-3-8(4-13(33-2)16(12)27)21-22(18(29)15-10(26)5-9(25)6-11(15)34-21)36-23-20(31)19(30)17(28)14(7-24)35-23/h3-6,14,17,19-20,23-28,30-31H,7H2,1-2H3/t14-,17-,19+,20-,23+/m1/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{FMK-MEA} web|{FMK-MEA} Inhibitor|{FMK-MEA} Activator|{FMK-MEA} Purity & Documentation|{FMK-MEA} In stock|{FMK-MEA} custom synthesis} |Shelf Life: ≥12 months if stored properly.{{Flubendazole} web|{Flubendazole} Autophagy|{Flubendazole} Protocol|{Flubendazole} In Vivo|{Flubendazole} custom synthesis|{Flubendazole} Autophagy} |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.PMID:23489613 |Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|

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Mahanine is a carbazole alkaloid with various biological properties.PMID:23489613 Mahanine is a potent anticancer agent against different types of cancer cells. Mahanine exhibits antileishmanial activity and can be used for Leishmania infection treatment research.|Product information|CAS Number: 28360-49-8|Molecular Weight: 347.45|Formula: C23H25NO2|Chemical Name: (3R)-3,5-dimethyl-3-(4-methylpent-3-en-1-yl)-3H,11H-pyrano[3,2-a]carbazol-9-ol|Smiles: CC(C)=CCC[C@]1(C)C=CC2C3NC4=CC(O)=CC=C4C=3C=C(C)C=2O1|InChiKey: DWMBXHWBPZZCTN-HSZRJFAPSA-N|InChi: InChI=1S/C23H25NO2/c1-14(2)6-5-10-23(4)11-9-18-21-19(12-15(3)22(18)26-23)17-8-7-16(25)13-20(17)24-21/h6-9,11-13,24-25H,5,10H2,1-4H3/t23-/m1/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|Mahanine (0-50 µM; 24 or 48 hours) induces a dose-dependent decrease in cell viability of AG83 promastigotes after 24 hr and 48 hr; the IC50 values were 16.7±1.7 µM and 11.5±0.8 µM respectively. In a drug resistant GE1 strain, Mahanine treatment exhibits dose-dependent cell death in 24 and 48 hr treatment with IC50 values 40.3±2.2 µM and 29.1±1.3 µM respectively. Mahanine (5.0 and 10 µM; 24 hours) exhibits increased accumulation of cells at G2/M phase being 39.0±1.90% and 41.0±2.10% respectively compared to untreated promastigotes (35.3 ± 2.60%) in AG83 promastigote . Mahanine (25 µM; 24 hours) exhibitssignificantly increased intracellular ROS level within 20 min (MFI being 889 ± 26) which reached to 1288 ± 56 after one hour compared to the basal level (604 ± 34) in untreated promastigote. H2DCFDA positivity was measured by FACS.|In Vivo:|Mahanine (oral gavage; 20 mg/kg/40 mg/kg; b.w/day; 5 days) results in 89.1±4.1% reductions in parasite burden at 20 mg/kg, and leads to 96.2±0.3% reductions in parasite burden at 40 mg/kg in a well-established acute model to control Leishmania infection.|Products are for research use only. Not for human use.|

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Exendin-4 acetate (Exenatide acetate), a 39 amino acid peptide, is a long-acting glucagon-like peptide-1 receptor agonist with an IC50 of 3.22 nM.|Product information|CAS Number: 914454-01-6|Molecular Weight: 4917.24|Formula: C212H328N52O80S|Chemical Name: (2R, 4S, 5R, 6S)-5-acetamido-2-[[(2R, 3R, 4S, 5R, 6S)-6-[(2R, 3S, 4R, 5R, 6R)-5-acetamido-6-[[(3S)-3-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S, 3S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-5-amino-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S, 3R)-2-[[(2S)-2-[[(2S, 3R)-2-[[2-[[(2S)-2-[[2-[[(2S)-2-amino-3-(1H-imidazol-5-yl)propanoyl]amino]acetyl]amino]-4-carboxybutanoyl]amino]acetyl]amino]-3-hydroxybutanoyl]amino]-3-phenylpropanoyl]amino]-3-hydroxybutanoyl]amino]-3-hydroxypropanoyl]amino]-3-carboxypropanoyl]amino]-4-methylpentanoyl]amino]-3-hydroxypropanoyl]amino]hexanoyl]amino]-5-oxopentanoyl]amino]-4-methylsulfanylbutanoyl]amino]-4-carboxybutanoyl]amino]-4-carboxybutanoyl]amino]-4-carboxybutanoyl]amino]propanoyl]amino]-3-methylbutanoyl]amino]-5-carbamimidamidopentanoyl]amino]-4-methylpentanoyl]amino]-3-phenylpropanoyl]amino]-3-methylpentanoyl]amino]-4-carboxybutanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]amino]-4-[[2-[[2-[(2S)-2-[[(2S)-1-[[(2S)-1-[[2-[[(2S)-1-[(2S)-2-[(2S)-2-[(2S)-2-[[(2S)-1-amino-3-hydroxy-1-oxopropan-2-yl]carbamoyl]pyrrolidine-1-carbonyl]pyrrolidine-1-carbonyl]pyrrolidin-1-yl]-1-oxopropan-2-yl]amino]-2-oxoethyl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]carbamoyl]pyrrolidin-1-yl]-2-oxoethyl]amino]-2-oxoethyl]amino]-4-oxobutanoyl]amino]-4-hydroxy-2-(hydroxymethyl)oxan-3-yl]oxy-3, 4, 5-trihydroxyoxan-2-yl]methoxy]-4-hydroxy-6-[(2S, 3R)-2, 3, 4-trihydroxybutyl]oxane-2-carboxylic acid;acetate|Smiles: CC[C@H](C)[C@H](NC(=O)[C@H](CC1C=CC=CC=1)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCSC)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC1C=CC=CC=1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)CNC(=O)[C@@H](N)CC1=CN=CN1)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC1=CNC2=CC=CC=C12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(=O)N[C@@H]1O[C@H](CO)[C@@H](O[C@@H]2O[C@H](CO[C@@]3(C[C@H](O)[C@@H](NC(C)=O)[C@H](C[C@H](O)[C@H](O)CO)O3)C(O)=O)[C@H](O)[C@H](O)[C@H]2O)[C@H](O)[C@H]1NC(C)=O)C(=O)NCC(=O)NCC(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(N)=O.{{p-Coumaric acid} site|{p-Coumaric acid} Endogenous Metabolite|{p-Coumaric acid} Purity & Documentation|{p-Coumaric acid} In Vivo|{p-Coumaric acid} custom synthesis|{p-Coumaric acid} Cancer} CC(O)=O|InChiKey: YGHQSTMXYLWAJN-ZAVVHXGLSA-N|InChi: InChI=1S/C210H324N52O78S.{{Anti-Mouse CD209b Antibody} medchemexpress|{Anti-Mouse CD209b Antibody} Protocol|{Anti-Mouse CD209b Antibody} References|{Anti-Mouse CD209b Antibody} supplier|{Anti-Mouse CD209b Antibody} Autophagy} C2H4O2/c1-18-101(10)162(200(328)240-123(54-60-159(292)293)185(313)245-130(75-110-81-220-114-41-26-25-40-112(110)114)190(318)242-125(70-97(2)3)187(315)232-116(43-28-30-63-212)180(308)246-131(77-149(278)255-203-166(230-107(16)273)168(297)171(146(94-269)337-203)339-207-170(299)169(298)167(296)147(338-207)95-336-210(208(334)335)80-143(275)165(229-106(15)272)145(340-210)79-142(274)144(276)93-268)176(304)223-83-150(279)221-87-154(283)259-65-32-45-138(259)197(325)252-136(91-266)196(324)250-134(89-264)177(305)225-84-151(280)227-103(12)204(331)261-67-34-47-140(261)206(333)262-68-35-48-141(262)205(332)260-66-33-46-139(260)198(326)249-133(88-263)172(215)300)257-192(320)128(73-108-36-21-19-22-37-108)244-188(316)126(71-98(4)5)241-181(309)117(44-31-64-219-209(216)217)239-199(327)161(100(8)9)256-173(301)102(11)228-178(306)120(51-57-156(286)287)235-183(311)121(52-58-157(288)289)236-184(312)122(53-59-158(290)291)237-186(314)124(61-69-341-17)238-182(310)119(49-55-148(214)277)234-179(307)115(42-27-29-62-211)233-194(322)135(90-265)251-189(317)127(72-99(6)7)243-191(319)132(78-160(294)295)247-195(323)137(92-267)253-202(330)164(105(14)271)258-193(321)129(74-109-38-23-20-24-39-109)248-201(329)163(104(13)270)254-153(282)86-224-175(303)118(50-56-155(284)285)231-152(281)85-222-174(302)113(213)76-111-82-218-96-226-111;1-2(3)4/h19-26,36-41,81-82,96-105,113,115-147,161-171,203,207,220,263-271,274-276,296-299H,18,27-35,42-80,83-95,211-213H2,1-17H3,(H2,214,277)(H2,215,300)(H,218,226)(H,221,279)(H,222,302)(H,223,304)(H,224,303)(H,225,305)(H,227,280)(H,228,306)(H,229,272)(H,230,273)(H,231,281)(H,232,315)(H,233,322)(H,234,307)(H,235,311)(H,236,312)(H,237,314)(H,238,310)(H,239,327)(H,240,328)(H,241,309)(H,242,318)(H,243,319)(H,244,316)(H,245,313)(H,246,308)(H,247,323)(H,248,329)(H,249,326)(H,250,324)(H,251,317)(H,252,325)(H,253,330)(H,254,282)(H,255,278)(H,256,301)(H,257,320)(H,258,321)(H,284,285)(H,286,287)(H,288,289)(H,290,291)(H,292,293)(H,294,295)(H,334,335)(H4,216,217,219);1H3,(H,3,4)/t101-,102-,103-,104+,105+,113-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,137-,138-,139-,140-,141-,142-,143-,144+,145-,146+,147+,161-,162-,163-,164-,165+,166+,167-,168+,169-,170+,171+,203+,207-,210+;/m0.PMID:24059181 /s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : ≥ 66.66 mg/mL (15.70 mM). H2O : 1 mg/mL (0.24 mM; Need ultrasonic).|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|In human umbilical vein endothelial cells, Exendin-4 significantly increases NO production, endothelial NO synthase (eNOS) phosphorylation, and GTP cyclohydrolase 1 (GTPCH1) level in a dose-dependent manner. Exendin-4 shows cytotoxic effects to MCF-7 breast cancer cells with IC50 of 5 μM at 48 hour.|In Vivo:|Both low- and high-dose Exendin-4 treatment in ob/ob mice improve serum ALT and reduce serum glucose, and calculated HOMA scores compared with control. Exendin-4-treated ob/ob mice sustain a marked reduction in the net weight gain in the final 4 weeks of the study period. Animals treated with Exendin-4 have more pancreatic acinar inflammation, more pyknotic nuclei and weigh significantly less than control rats. Exendin-4 treatment is associated with lower leptin levels as well as lower HOMA values in rats. Exenatide causes dose-dependent relaxation of rat thoracic aorta, which is evoked via the GLP-1 receptor and is mediated mainly by H2S but also by NO and CO.|Products are for research use only. Not for human use.|

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Azatadine is a first-generation antihistamine and anticholinergic. It has been succeeded by both loratadine and desloratadine.|Product information|CAS Number: 3964-81-6|Molecular Weight: 290.40|Formula: C20H22N2|Synonym:|Optimine|Chemical Name: 2-(1-methylpiperidin-4-ylidene)-4-azatricyclo[9.4.0.0³,⁸]pentadeca-1(15),3,5,7,11,13-hexaene|Smiles: CN1CCC(CC1)=C1C2=NC=CC=C2CCC2=CC=CC=C21|InChiKey: SEBMTIQKRHYNIT-UHFFFAOYSA-N|InChi: InChI=1S/C20H22N2/c1-22-13-10-16(11-14-22)19-18-7-3-2-5-15(18)8-9-17-6-4-12-21-20(17)19/h2-7,12H,8-11,13-14H2,1H3|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Risperidone} site|{Risperidone} Neuronal Signaling|{Risperidone} Protocol|{Risperidone} Data Sheet|{Risperidone} supplier|{Risperidone} Epigenetics} |Shelf Life: ≥12 months if stored properly.{{Bicuculline} MedChemExpress|{Bicuculline} GABA Receptor|{Bicuculline} Biological Activity|{Bicuculline} Data Sheet|{Bicuculline} supplier|{Bicuculline} Epigenetic Reader Domain} |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.PMID:24578169 |Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|

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Chemical dimerizer used in auxin-inducible degron (AID) systems. Induces degradation of a target protein tagged with the auxin-receptor F-box protein Tir1 E3 ligase AID in human colorectral cancer and mouse ES cells or tagged with AFB2 in A431 cells. Endogenous plant hormone.|Product information|CAS Number: 87-51-4|Molecular Weight: 175.18|Formula: C10H9NO2|Synonym:|indolylacetic acid|1H-Indole-3-acetic acid|indoleacetic acid|heteroauxin|IAA|Chemical Name: indole-3-acetic acid|Smiles: OC(=O)CC1=CNC2=CC=CC=C21|InChiKey: SEOVTRFCIGRIMH-UHFFFAOYSA-N|InChi: InChI=1S/C10H9NO2/c12-10(13)5-7-6-11-9-4-2-1-3-8(7)9/h1-4,6,11H,5H2,(H,12,13)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO: 35 mg/mL(199.79 mM). Water: undefined.|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Eugenol} medchemexpress|{Eugenol} Apoptosis|{Eugenol} Purity & Documentation|{Eugenol} In Vitro|{Eugenol} custom synthesis|{Eugenol} Autophagy} |Shelf Life: ≥12 months if stored properly.PMID:36628218 |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|Indole-3-acetic acid (IAA) induces cytotoxicity in fibroblasts, neutrophils, and several cancer lineages in vitro.|In Vivo:|IAA administration in pregnant rats during days 12-14 might selectively affect the S phase neurons and lead to their apoptosis in the neuroepithelium. It induces microencephaly in rats.|References:|Furukawa S, et al. Toxicol Pathol. 2004, 32(6):659-67.Products are for research use only. Not for human use.|

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GSK256066 is a potent and selective PDE4 inhibitor that can be given by inhalation, minimising the potential for side effects. GSK256066 demonstrated a protective effect on the EAR and LAR. GSK256066 is a slow and tight binding inhibitor of PDE4B (apparent IC(50) 3.2 pM; steady-state IC(50) Product information|CAS Number: 801312-28-7|Molecular Weight: 518.58|Formula: C27H26N4O5S|Synonym:|GSK256066|GSK-256066|GSK 256066|Related CAS Number:|801315-14-0 (HCl)|1415560-64-3 (TFA)|Chemical Name: 6-[3-(dimethylcarbamoyl)benzenesulfonyl]-4-[(3-methoxyphenyl)amino]-8-methylquinoline-3-carboxamide|Smiles: CC1=CC(=CC2=C1N=CC(C(N)=O)=C2NC1=CC(=CC=C1)OC)S(=O)(=O)C1=CC(=CC=C1)C(=O)N(C)C|InChiKey: JFHROPTYMMSOLG-UHFFFAOYSA-N|InChi: InChI=1S/C27H26N4O5S/c1-16-11-21(37(34,35)20-10-5-7-17(12-20)27(33)31(2)3)14-22-24(16)29-15-23(26(28)32)25(22)30-18-8-6-9-19(13-18)36-4/h5-15H,1-4H3,(H2,28,32)(H,29,30)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: Solubility (25°C) DMSO: 5 mg/mL(9.64 mM). Water: Insoluble.|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|GSK256066 is a slow and tight binding inhibitor of PDE4B with apparent IC50 of 3.2 pM. GSK256066 is an extremely potent inhibitor of LPS-stimulated TNFα production in PBMCs with pIC50 of 11.0 and IC50 of 10 pM and human whole-blood cultures with pIC50 of 9.90 and IC50 of 126 pM. GSK256066 is highly selective for PDE4 (>3.8 × 105-fold versus PDE1, PDE2, PDE3, PDE5, and PDE6 and >2.5 × 103-fold against PDE7). GSK256066 inhibits PDE4 isoforms A-D with equal affinity.|In Vivo:|GSK256066 inhibits the LPS-induced pulmonary neutrophilia with an ED50 of 1.1 μg/kg, achieving maximal inhibition of 72% at 30 μg/kg when given in the aqueous suspension.PMID:26895888 GSK256066 inhibits the LPS-induced pulmonary neutrophilia with ED50 of 2.9 μg/kg, achieving maximal inhibition of 62% when given in the dry powder formulation. GSK256066 shows a moderate plasma clearance of 39 ml/min/kg, a moderate volume of distribution of 0.8 L/kg, and a relatively short half-life of 1.1 hour in the male CD rat. GSK256066 sustains at a high lung concentration of 2.6 μg/g after intra-tracheal administration as an aqueous suspension at a dose of 30 μg/kg in rats. GSK256066 (10 μg/kg) is administered intratracheally at different times (2, 6, 12, 18, 24, and 36 hours) before LPS administration, inhibiting LPS-Induced Pulmonary Neutrophilia in rat lipopolysaccharide (LPS)-induced models of acute pulmonary inflammation. GSK256066 (0.3–100 μg/kg) inhibits LPS-induced increases in exhaled nitric oxide with ED50 of 35 μg/kg in rat. GSK256066 (10 μg/kg) is administered half a hour before OVA administration in rat, inhibiting OVA-induced pulmonary eosinophilia with ED50 of 0.4 μg/kg. GSK256066 administered intratracheally as a dry powder blended in respiratory-grade lactose at doses of 3 to 100 μg/kg 2 hours before inhaled LPS challenge in ferrets, inhibiting LPS-induced pulmonary neutrophilia with ED50 of 18 μg/kg without inducing emetic episodes.|References:|Nials AT, et al. J Pharmacol Exp Ther, 2011, 337(1), 137-144.Woodrow MD, et al. Bioorg Med Chem Lett, 2009, 19(17), 5261-5265.Tralau-Stewart CJ, et al. J Pharmacol Exp Ther, 2011, 337(1), 145-154.Products are for research use only. Not for human use.|

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Matrine (Matridin-15-one) is an alkaloid found in plants from the Sophora genus. It has a variety of pharmacological effects, including anti-cancer effects, and action as a kappa opioid receptor and u-receptor agonist.|Product information|CAS Number: 519-02-8|Molecular Weight: 248.36|Formula: C15H24N2O|Synonym:|Matridin-15-one|NSC 146051|NSC146051|NSC-146051|Chemical Name: (1R, 2R, 9S, 17S)-7, 13-diazatetracyclo[7.{{DBCO-Biotin} MedChemExpress|{DBCO-Biotin} PROTAC Linkers|{DBCO-Biotin} Epigenetics|{DBCO-Biotin} Protocol|{DBCO-Biotin} In stock|{DBCO-Biotin} manufacturer} 7.1.0, .0, ]heptadecan-6-one|Smiles: O=C1CCC[C@@H]2[C@H]3CCCN4CCC[C@@H](CN12)[C@H]43|InChiKey: ZSBXGIUJOOQZMP-JLNYLFASSA-N|InChi: InChI=1S/C15H24N2O/c18-14-7-1-6-13-12-5-3-9-16-8-2-4-11(15(12)16)10-17(13)14/h11-13,15H,1-10H2/t11-,12+,13+,15-/m0/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO: 49 mg/mL(197.29 mM). Water: 11 mg/mLwarmed(44.29 mM).|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Guanidine} medchemexpress|{Guanidine} Endogenous Metabolite|{Guanidine} Purity & Documentation|{Guanidine} Formula|{Guanidine} custom synthesis|{Guanidine} Epigenetics} |Shelf Life: ≥12 months if stored properly.PMID:24605203 |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|Matrine((+)-Matrine) is an alkaloid found in plants from the Sophora family, which has a variety of pharmacological effects, including anti-cancer effects, and action as a kappa opioid receptor agonist. Matrine significantly inhibites the growth of human non-small cell lung cancer A549 and hepatoma SMMC-7721 cells and induces apoptosis by strongly reducing the viability and the ratio of Bcl-2/Bax protein in A549 cells. matrine may stimulate the descending dynorphinergic neuron, resulting in the stimulation of kappa-opioid receptors (KORs) in the spinal cord, and this phenomenon in turn produces the antinociception in mice.|In Vivo:|LD50: Mice 157mg/kg (i.p.)|References:|Wang XY, et al. Nanfang Yike Daxue Xuebao, 2010, 30(9), 2154-2155.Higashiyama K, et al. Biol Pharm Bull, 2005, 28(5), 845-848.Zhang Y, et al. Cytotechnology, 2009, 59(3), 191-200.Products are for research use only. Not for human use.|

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Chondroitin sulfate, one of five classes of glycosaminoglycans, has been widely used in the treatment of osteoarthritis. Chondroitin sulfate reduces inflammation mediators and the apoptotic process and is able to reduce protein production of inflammatory cytokines, iNOS and MMPs.|Product information|CAS Number: 9007-28-7|Synonym:|Chondroitin polysulfate|Chemical Name: Chondroitin sulfate|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: H2O : ≥ 50 mg/mL|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|Chondroitin sulfate is a class of sulfated glycosaminoglycans that are linear polysaccharides consisting of repeating disaccharide units composed of uronic acid and N-acetylhexosamine. Several pathogens including parasites, bacteria, and viruses have been shown to utilize cell surface chondroitin sulfate chains to attach to and infect host cells[1]. Chondroitin sulfate occurs naturally in the extracellular matrix of connective tissues, e.g., bone, cartilage, skin, ligaments and tendons. Chondroitin sulfate has been shown to elicit a range of beneficial effects: anti-inflammatory effects, an increase in type II collagen and proteoglycans, a reduction in bone resorption and a better anabolic/catabolic balance in chondrocytes[2]. A large range of chondroitin sulfate concentrations has been used (e.g. 12.5 to 2000 mg/mL, but generally less than200 mg/mL) in in vitro studies. Chondroitin sulfate (200 mg/mL) decreases the chondrocyte susceptibility to single nucleotide polymorphism-induced apoptosis[3]. Chondroitin sulfate reduces inflammation mediators and the apoptotic process and is able to reduce protein production of inflammatory cytokines, iNOS, MMPs[4].|In Vivo:|The high content of chondroitin sulfate in the aggrecan plays a major part in allowing cartilage to resist tensile stresses during various loading conditions by providing this tissue with resistance and elasticity. It has been shown that chondroitin sulphate interferes with the progression of structural changes in joint tissues and is used in the management of patients with osteoarthritis[3].{{Protein G Agarose} web|{Protein G Agarose} Biological Activity|{Protein G Agarose} Formula|{Protein G Agarose} custom synthesis|{Protein G Agarose} Cancer} Chondroitin sulfate is mostly administered orally at doses ranging from 800 to 1200mg/day.{{Apocynin} MedChemExpress|{Apocynin} Metabolic Enzyme/Protease|{Apocynin} Biological Activity|{Apocynin} Formula|{Apocynin} manufacturer|{Apocynin} Cancer} Chondroitin sulfate is rapidly absorbed by the gastrointestinal tract.PMID:23833812 The absorbed chondroitin sulfate reaches the blood compartment as 10% chondroitin sulfate and 90% depolymerized low-molecular-weight derivatives[5].|References:|Mikami T, et al. Biosynthesis and function of chondroitin sulfate. Biochim Biophys Acta. 2013 Oct;1830(10):4719-33.Martel-Pelletier J, et al.Discrepancies in composition and biological effects of different formulations of chondroitin sulfate. Molecules. 2015 Mar 6;20(3):4277-89.Monfort J, et al. Biochemical basis of the effect of chondroitin sulphate on osteoarthritis articular tissues. Ann Rheum Dis. 2008 Jun;67(6):735-40.Campo GM, et al. Glycosaminoglycans modulate inflammation and apoptosis in LPS-treated chondrocytes. J Cell Biochem. 2009 Jan 1;106(1):83-92.Henrotin Y, et al. Chondroitin sulfate in the treatment of osteoarthritis: from in vitro studies to clinicalrecommendations. Ther Adv Musculoskelet Dis. 2010 Dec;2(6):335-48.Products are for research use only. Not for human use.|

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7-Methoxyisoflavone (MIF) is a potent activator of adenosine monophosphate-activated protein kinase (AMPK).|Product information|CAS Number: 1621-56-3|Molecular Weight: 252.26|Formula: C16H12O3|Chemical Name: 7-methoxy-3-phenyl-4H-chromen-4-one|Smiles: COC1=CC2OC=C(C(=O)C=2C=C1)C1C=CC=CC=1|InChiKey: IECSQLKWZBEUGA-UHFFFAOYSA-N|InChi: InChI=1S/C16H12O3/c1-18-12-7-8-13-15(9-12)19-10-14(16(13)17)11-5-3-2-4-6-11/h2-10H,1H3|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : 25 mg/mL (99.{{Scopoletin} MedChemExpress|{Scopoletin} Apoptosis|{Scopoletin} Protocol|{Scopoletin} In Vivo|{Scopoletin} supplier|{Scopoletin} Autophagy} 10 mM; Need ultrasonic)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Tivozanib} MedChemExpress|{Tivozanib} Protein Tyrosine Kinase/RTK|{Tivozanib} Biological Activity|{Tivozanib} Data Sheet|{Tivozanib} supplier|{Tivozanib} Autophagy} |Shelf Life: ≥12 months if stored properly.PMID:24455443 |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|7-Methoxyisoflavone is an isoflavone derivative and also an activator of adenosine monophosphate-activated protein kinase (AMPK). When serum-starved cells are treated with 10 % FBS in the presence of 7-methoxyisoflavone, the serum-induced decrease in AMPK phosphorylation is prevented.|References:|Hyeryoung Jung, et al. Isoflavones as modulators of adenosine monophosphate-activated protein kinase. Applied Biological Chemistry. 2016. 59, 217-225.Products are for research use only. Not for human use.|

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GRL0617 is a potent, selective and competitive noncovalent inhibitor of SARS PLPro. GRL0617, inhibited SARS-CoV viral replication in Vero E6 cells with an EC(50) of 15 microM and had no associated cytotoxicity. The X-ray structure of PLpro in complex with GRL0617 indicates that the compound has a unique mode of inhibition whereby it binds within the S4-S3 subsites of the enzyme and induces a loop closure that shuts down catalysis at the active site.{{Emtricitabine} MedChemExpress|{Emtricitabine} Endogenous Metabolite|{Emtricitabine} Protocol|{Emtricitabine} Formula|{Emtricitabine} supplier|{Emtricitabine} Epigenetic Reader Domain} |Product information|CAS Number: 1093070-16-6|Molecular Weight: 304.{{Capsaicin} medchemexpress|{Capsaicin} Apoptosis|{Capsaicin} Biological Activity|{Capsaicin} In Vitro|{Capsaicin} supplier|{Capsaicin} Autophagy} 39|Formula: C20H20N2O|Synonym:|GRL-0617|GRL0617|GRL 0617|Chemical Name: 5-Amino-2-methyl-N-[(1R)-1-(1-naphthalenyl)ethyl]benzamide|Smiles: CC1=CC=C(N)C=C1C(=O)N[C@H](C)C1=CC=CC2=CC=CC=C21|InChiKey: UVERBUNNCOKGNZ-CQSZACIVSA-N|InChi: InChI=1S/C20H20N2O/c1-13-10-11-16(21)12-19(13)20(23)22-14(2)17-9-5-7-15-6-3-4-8-18(15)17/h3-12,14H,21H2,1-2H3,(H,22,23)/t14-/m1/s1|Technical Data|Appearance: Solid Power.PMID:35126464 |Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: Soluble in DMSO|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined.|HS Tariff Code: 382200|References:|Chaudhuri R, Tang S, Zhao G, Lu H, Case DA, Johnson ME. Comparison of SARS and NL63 papain-like protease binding sites and binding site dynamics: inhibitor design implications. J Mol Biol. 2011 Nov 25;414(2):272-88. doi: 10.1016/j.jmb.2011.09.030. Epub 2011 Sep 29. PubMed PMID: 22004941; PubMed Central PMCID: PMC3397151.Nathan J. SchauerRobert S. MaginXiaoxi LiuLaura M. DohertySara J. Buhrlage* Advances in Discovering Deubiquitinating Enzyme (DUB) Inhibitors. Journal of Medicinal Chemistry, Articles ASAP (Perspective). Publication Date (Web):November 4, 2019DOI: 10.1021/acs.jmedchem.9b01138.Products are for research use only. Not for human use.|

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VUN65671is a Potent Entry Inhibitor of Ebola and Marburg Virus Infections. VUN65671 was reported in Journal of Medicinal Chemistry (2020), 63(13), 7211-7225.|Product information|CAS Number: 2479465-67-1|Molecular Weight: 461.52|Formula: C25H30F3N3O2|Synonym:|VUN-65671|VUN65671|VUN 65671|Chemical Name: Benzamide,N-[4-(4-methyl-1-piperidinyl)-3-(trifluoromethyl)phenyl]-4-(4-morpholinylmethyl)-|Smiles: CC1CCN(CC1)C1=CC=C(C=C1C(F)(F)F)NC(=O)C1C=CC(CN2CCOCC2)=CC=1|InChiKey: VVJSZYWIEBDKTC-UHFFFAOYSA-N|InChi: InChI=1S/C25H30F3N3O2/c1-18-8-10-31(11-9-18)23-7-6-21(16-22(23)25(26,27)28)29-24(32)20-4-2-19(3-5-20)17-30-12-14-33-15-13-30/h2-7,16,18H,8-15,17H2,1H3,(H,29,32)|Technical Data|Appearance: Solid Power.|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: Soluble in DMSO|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Lanreotide} web|{Lanreotide} Biological Activity|{Lanreotide} Purity|{Lanreotide} supplier|{Lanreotide} Epigenetics} |Shelf Life: ≥360 days if stored properly.{{Sirukumab} site|{Sirukumab} Interleukin Related|{Sirukumab} Protocol|{Sirukumab} In Vivo|{Sirukumab} custom synthesis|{Sirukumab} Autophagy} |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.PMID:23514335 |Drug Formulation: To be determined.|HS Tariff Code: 382200|How to use|In Vitro:|EBOV/MARV-IN-1 (12.5 µM; 48 h) inhibits HIV/EBOV-GP (EC50=12 nM) and HIV/MARV-GP (EC50=180 nM) pseudotype virus in A549 cells containing a luciferase reporter gene, with low cytotoxicity (SI =2088).|References:|Gaisina IN, et, al. Discovery and Structural Optimization of 4-(Aminomethyl)benzamides as Potent Entry Inhibitors of Ebola and Marburg Virus Infections. J Med Chem. 2020 Jul 9;63(13):7211-7225.Products are for research use only. Not for human use.|

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YC-1 is a inhibitor of Hypoxia-inducible factor-1alpha (HIF-1alpha). YC-1 is widely used as a potent inhibitor of HIF-1alpha both in vitro and in vivo, and is also being developed as a novel anticancer drug. YC-1 effectively inhibits tumor invasion and metastasis, and imply that YC-1 is worth while to further develop as a multipurpose anticancer drug.|Product information|CAS Number: 170632-47-0|Molecular Weight: 304.34|Formula: C19H16N2O2|Synonym:|Lificiguat|YC1|YC 1|YC-1|Chemical Name: 5-[1-(phenylmethyl)-1H-indazol-3-yl]-2-furanmethanol|Smiles: OCC1=CC=C(O1)C1=NN(CC2C=CC=CC=2)C2=CC=CC=C21|InChiKey: OQQVFCKUDYMWGV-UHFFFAOYSA-N|InChi: InChI=1S/C19H16N2O2/c22-13-15-10-11-18(23-15)19-16-8-4-5-9-17(16)21(20-19)12-14-6-2-1-3-7-14/h1-11,22H,12-13H2|Technical Data|Appearance: Solid Power.PMID:24463635 |Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: Soluble in DMSO, not in water|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined.|HS Tariff Code: 382200|References:|Tsui L, Fong TH, Wang IJ. The effect of 3-(5′-hydroxymethyl-2′-furyl)-1-benzylindazole (YC-1) on cell viability under hypoxia. Mol Vis. 2013 Nov 16;19:2260-73. eCollection 2013. PubMed PMID: 24265542; PubMed Central PMCID: PMC3834593.Carroll CE, Liang Y, Benakanakere I, Besch-Williford C, Hyder SM. The anticancer agent YC-1 suppresses progestin-stimulated VEGF in breast cancer cells and arrests breast tumor development. Int J Oncol. 2013 Jan;42(1):179-87. doi: 10.3892/ijo.2012.1675. Epub 2012 Oct 24. PubMed PMID: 23123638; PubMed Central PMCID: PMC3583650.Tsui L, Fong TH, Wang IJ. YC-1 targeting of hypoxia-inducible factor-1α reduces RGC-5 cell viability and inhibits cell proliferation. Mol Vis. 2012;18:1594-603. Epub 2012 Jun 15. PubMed PMID: 22736948; PubMed Central PMCID: PMC3380911.Products are for research use only. Not for human use.|

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Ciraparantag (free base), also known as PER977, is a small molecule reversal agent for new oral anticoagulants and heparins. PER977 is a water-soluble, cationic molecule that is designed to bind specifically to unfractionated heparin and low-molecular-weight heparin through noncovalent hydrogen bonding and charge–charge interactions.|Product information|CAS Number: 1438492-26-2|Molecular Weight: 512.70|Formula: C22H48N12O2|Synonym:|PER977|PER-977|PER 977|Aripazine|Ciraparantag|Chemical Name: (2S,2’S)-N,N’-(piperazine-1,4-diylbis(propane-3,1-diyl))bis(2-amino-5-guanidinopentanamide)|Smiles: NC(=N)NCCC[C@H](N)C(=O)NCCCN1CCN(CC1)CCCNC(=O)[C@@H](N)CCCNC(N)=N|InChiKey: HRDUUSCYRPOMSO-ROUUACIJSA-N|InChi: InChI=1S/C22H48N12O2/c23-17(5-1-7-31-21(25)26)19(35)29-9-3-11-33-13-15-34(16-14-33)12-4-10-30-20(36)18(24)6-2-8-32-22(27)28/h17-18H,1-16,23-24H2,(H,29,35)(H,30,36)(H4,25,26,31)(H4,27,28,32)/t17-,18-/m0/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: Soluble in DMSO, not in water|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined.|HS Tariff Code: 382200|References:|Dzik WH. Reversal of oral factor Xa inhibitors by prothrombin complex concentrates: a re-appraisal. J Thromb Haemost. 2015 Jun;13 Suppl 1:S187-94. doi: 10.1111/jth.12949. PubMed PMID: 26149022.Crowther M, Crowther MA. Antidotes for Novel Oral Anticoagulants: Current Status and Future Potential.{{Nimodipine} MedChemExpress|{Nimodipine} Membrane Transporter/Ion Channel|{Nimodipine} Purity & Documentation|{Nimodipine} Data Sheet|{Nimodipine} supplier|{Nimodipine} Cancer} Arterioscler Thromb Vasc Biol.{{Biotin-PEG4-NHS ester} web|{Biotin-PEG4-NHS ester} PROTAC Linkers|{Biotin-PEG4-NHS ester} TGF-beta/Smad|{Biotin-PEG4-NHS ester} Technical Information|{Biotin-PEG4-NHS ester} References|{Biotin-PEG4-NHS ester} custom synthesis} 2015 Aug;35(8):1736-45.PMID:28739548 doi: 10.1161/ATVBAHA.114.303402. Epub 2015 Jun 18. PubMed PMID: 26088576.Sullivan DW Jr, Gad SC, Laulicht B, Bakhru S, Steiner S. Nonclinical Safety Assessment of PER977: A Small Molecule Reversal Agent for New Oral Anticoagulants and Heparins. Int J Toxicol. 2015 Jun 15. pii: 1091581815590667. [Epub ahead of print] PubMed PMID: 26079256.Mo Y, Yam FK. Recent advances in the development of specific antidotes for target-specific oral anticoagulants. Pharmacotherapy. 2015 Feb;35(2):198-207. doi: 10.1002/phar.1532. Epub 2015 Feb 3. PubMed PMID: 25644580.Yates SW. Interrupting anticoagulation in patients with nonvalvular atrial fibrillation. P T. 2014 Dec;39(12):858-80. PubMed PMID: 25516695; PubMed Central PMCID: PMC4264672.Products are for research use only. Not for human use.|

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CB-5083 is a novel first in class, potent orally bio-available p97 inhibitor that disrupts cellular protein homeostasis and demonstrates anti-tumor activity in solid and hematological models . CB-5083 causes rapid and sustained accumulation of poly-ubiquitin in tumor xenografts after a single administration. CB-5083 showed activity to inhibit tumor growth in multiple rodent models of human cancer. Furthermore, CB-5083 appears to exhibit greater potency over current proteasome inhibitors that further validate targeting p97 and protein homeostasis in the treatment of cancer.|Product information|CAS Number: 1542705-92-9|Molecular Weight: 413.47|Formula: C24H23N5O2|Chemical Name: 1-(4-(benzylamino)-7,8-dihydro-5H-pyrano[4,3-d]pyrimidin-2-yl)-2-methyl-1H-indole-4-carboxamide|Smiles: CC1=CC2C(=CC=CC=2C(N)=O)N1C1=NC2CCOCC=2C(NCC2C=CC=CC=2)=N1|InChiKey: RDALZZCKQFLGJP-UHFFFAOYSA-N|InChi: InChI=1S/C24H23N5O2/c1-15-12-18-17(22(25)30)8-5-9-21(18)29(15)24-27-20-10-11-31-14-19(20)23(28-24)26-13-16-6-3-2-4-7-16/h2-9,12H,10-11,13-14H2,1H3,(H2,25,30)(H,26,27,28)|Technical Data|Appearance: Solid Power.{{Carbamazepine} web|{Carbamazepine} Sodium Channel|{Carbamazepine} Technical Information|{Carbamazepine} In Vitro|{Carbamazepine} manufacturer|{Carbamazepine} Cancer} |Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO up to 100 mM|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Biotin-PEG4-NHS ester} web|{Biotin-PEG4-NHS ester} PROTAC Linkers|{Biotin-PEG4-NHS ester} Epigenetics|{Biotin-PEG4-NHS ester} Protocol|{Biotin-PEG4-NHS ester} References|{Biotin-PEG4-NHS ester} supplier} |Shelf Life: ≥12 months if stored properly.PMID:24914310 |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined.|HS Tariff Code: 382200|How to use|In Vitro:|CB-5083 was used at 1-2.5 µM final concentration in various assays.|In Vivo:|CB-5083 was dosed to mice orally at 25-100 mg/Kg once or twice per day.|References:|Zhou HJ, et al. Discovery of a First-in-Class, Potent, Selective, and Orally Bioavailable Inhibitor of the p97 AAA ATPase (CB-5083). (2015) J Med Chem. 58(24):9480-97.Products are for research use only. Not for human use.|Documents||

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AR7 was developed as a highly potent and selective enhancer of the chaperone-mediated autophagy (CMA) through antagonizing RARα.PMID:24268253 It is a synthetic derivative of all-trans-retinoic acid developed through the structure-based chemical design. CMA contributes to cellular quality control and the cellular response to stress through the selective degradation of cytosolic proteins in lysosomes. A decrease in CMA activity occurs in aging and in age-related disorders (such as neurodegenerative diseases and diabetes). AR7 is the first small molecule developed to selectively stimulate CMA without affecting macroautophagy. Importantly, AR7 was shown to protect cells from oxidative stress and proteotoxicity, presenting a potential therapeutic strategy against cellular dysfunction and disease resulted from reduced CMA.|Product information|CAS Number: 80306-38-3|Molecular Weight: 257.71|Formula: C15H12ClNO|Synonym:|AR-7|AR 7|AR7|Atypical retinoid 7|Chemical Name: 7-chloro-3-(p-tolyl)-2H-benzo[b][1,4]oxazine|Smiles: CC1C=CC(=CC=1)C1COC2=CC(Cl)=CC=C2N=1|InChiKey: MVOZLTFXYGHZPM-UHFFFAOYSA-N|InChi: InChI=1S/C15H12ClNO/c1-10-2-4-11(5-3-10)14-9-18-15-8-12(16)6-7-13(15)17-14/h2-8H,9H2,1H3|Technical Data|Appearance: Solid Power.|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO up to 100 mM|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined.|HS Tariff Code: 382200|How to use|In Vitro:|AR7 was suggested to be used at 5-20 µM final concentration in vitro and in cellular assays.|References:|Anguiano J, et al. Chemical modulation of chaperone-mediated autophagy by retinoic acid derivatives. (2013) Nat Chem Biol. 9(6):374-82.Products are for research use only. Not for human use.|

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LY2109761 is a highly potent and selective TGFβ receptor type I and type II (TβRI/II) inhibitor with Ki of 38 nM and 300 nM respectively.PMID:23910527 Blocking TβRI/II kinase activity with LY2109761 completely suppresses both the basal and TGF-β1-stimulated migration and invasion of L3.6pl/GLT cells, and completely suppresses TGF-β–induced Smad2 phosphorylation. LY2109761 treatment at 1 nM is sufficient to significantly block the migration and invasion but not adhesion of hepatocellular carcinoma cells by increasing E-cadherin expression. It can also reduce the self-renewal and proliferation of GBM-derived cancer stem–like cells, which can be significantly enhanced when combined with radiation. Administration of LY2109761 alone or in combination with gemcitabine or with radiation demonstrated very good efficacy in multiple xenograft mice models.|Product information|CAS Number: 700874-71-1|Molecular Weight: 441.52|Formula: C26H27N5O2|Synonym:|LY 2109761|LY-2109761|Chemical Name: 4-(2-((4-(2-(pyridin-2-yl)-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl)quinolin-7-yl)oxy)ethyl)morpholine|Smiles: C(COC1=CC2=NC=CC(C3C(=NN4CCCC4=3)C3=CC=CC=N3)=C2C=C1)N1CCOCC1|InChiKey: IHLVSLOZUHKNMQ-UHFFFAOYSA-N|InChi: InChI=1S/C26H27N5O2/c1-2-9-27-22(4-1)26-25(24-5-3-11-31(24)29-26)21-8-10-28-23-18-19(6-7-20(21)23)33-17-14-30-12-15-32-16-13-30/h1-2,4,6-10,18H,3,5,11-17H2|Technical Data|Appearance: Solid Power.|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO up to 100 mM|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined.|HS Tariff Code: 382200|How to use|In Vitro:|LY2109761 was usually used at 5-10 µM in vitro and in cellular assays.|In Vivo:|LY2109761 was orally dosed to mice at 50 mg/kg once per day or in combination with gemcitabine (25 mg/kg) to significantly reduce the tumor volume.|References:|Li HY, et al. Optimization of a dihydropyrrolopyrazole series of transforming growth factor-beta type I receptor kinase domain inhibitors: discovery of an orally bioavailable transforming growth factor-beta receptor type I inhibitor as antitumor agent. (2008) J Med Chem. 51(7):2302-6.Melisi D, et al. LY2109761, a novel transforming growth factor beta receptor type I and type II dual inhibitor, as a therapeutic approach to suppressing pancreatic cancer metastasis. (2008) Mol Cancer Ther. 7(4):829-40.Zhang B, et al. Targeting transforming growth factor-beta signaling in liver metastasis of colon cancer. (2009) Cancer Lett. 277(1):114-20.Connolly EC, et al. Outgrowth of drug-resistant carcinomas expressing markers of tumor aggression after long-term TβRI/II kinase inhibition with LY2109761. (2011) Cancer Res. 71(6):2339-49.Zhang M, et al. Blockade of TGF-β signaling by the TGFβR-I kinase inhibitor LY2109761 enhances radiation response and prolongs survival in glioblastoma. (2011) Cancer Res. 71(23):7155-67.Flechsig P, et al. LY2109761 Attenuates Radiation-Induced Pulmonary Murine Fibrosis via Reversal of TGF-β and BMP-Associated Proinflammatory and Proangiogenic Signals. (2012) Clin Cancer Res. 18(13):3616-27Products are for research use only. Not for human use.|Documents||

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TNP-351 is an antifolate.{{BMP-4 Protein, Human} web|{BMP-4 Protein, Human} Technical Information|{BMP-4 Protein, Human} Description|{BMP-4 Protein, Human} custom synthesis|{BMP-4 Protein, Human} Autophagy} TNP-351, a dihydrofolate reductase (DHFR) inhibitor, has potent antitumor activity against not only leukemia cells but also solid tumor cells in vitro and in vivo.{{Gimeracil} web|{Gimeracil} Purity & Documentation|{Gimeracil} In stock|{Gimeracil} custom synthesis|{Gimeracil} Autophagy} |Product information|CAS Number: 125991-51-7|Molecular Weight: 440.45|Formula: C21H24N6O5|Chemical Name: (2S)-2-{[4-(3-{2,4-diamino-7H-pyrrolo[2,3-d]pyrimidin-5-yl}propyl)phenyl]formamido}pentanedioic acid|Smiles: NC1N=C(N)C2=C(NC=C2CCCC2C=CC(=CC=2)C(=O)N[C@@H](CCC(O)=O)C(O)=O)N=1|InChiKey: WLGCEMWNUHSIIS-AWEZNQCLSA-N|InChi: InChI=1S/C21H24N6O5/c22-17-16-13(10-24-18(16)27-21(23)26-17)3-1-2-11-4-6-12(7-5-11)19(30)25-14(20(31)32)8-9-15(28)29/h4-7,10,14H,1-3,8-9H2,(H,25,30)(H,28,29)(H,31,32)(H5,22,23,24,26,27)/t14-/m0/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.PMID:24733396 |Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|TNP-351 inhibits the proliferation of mouse L1210 leukemia cells and human CCRF-CEM lymphoblastic leukemia cells with ED50 values of 0.79 and 2.7 nM, respectively. The ED50 values determined for the parent cell line CCRF-CEM, CCRFCEM R30/6 subline, CCRF-CEM R1, and CCRF-CEM R2 are 2.7, 5.8, 94 and 76 nM, respectively.|Products are for research use only. Not for human use.|

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CL2 Linker is a cleavableADC linker.PMID:24733396 CL2-SN-38 and CL2A-SN-38 are equivalent in drug substitution (~6), cell binding (Kd ~1.2 nM), cytotoxicity (IC50 ~2.2 nM), and serum stability in vitro (t1/2 ~20 hours).|Product information|CAS Number: 2270986-66-6|Molecular Weight: 1426.61|Formula: C68H103N11O22|Chemical Name: tert-butyl N-[(5S)-5-[(2S)-2-[1-(4-{[6-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)hexanamido]methyl}-1H-1,2,3-triazol-1-yl)-3,6,9,12,15,18,21,24-octaoxaheptacosan-27-amido]-3-phenylpropanamido]-5-{[4-({[(2-{[(3-hydroxy-2-oxopropoxy)carbonyl](methyl)amino}ethyl)(methyl)carbamoyl]oxy}methyl)phenyl]carbamoyl}pentyl]carbamate|Smiles: CN(CCN(C)C(=O)OCC(=O)CO)C(=O)OCC1C=CC(=CC=1)NC(=O)[C@H](CCCCNC(=O)OC(C)(C)C)NC(=O)[C@H](CC1C=CC=CC=1)NC(=O)CCOCCOCCOCCOCCOCCOCCOCCOCCN1C=C(CNC(=O)CCCCCN2C(=O)C=CC2=O)N=N1|InChiKey: BGFZCTPREVDQQQ-YQOHNZFASA-N|InChi: InChI=1S/C68H103N11O22/c1-68(2,3)101-65(88)69-25-12-11-16-57(63(86)71-54-20-18-53(19-21-54)50-99-66(89)76(4)27-28-77(5)67(90)100-51-56(81)49-80)73-64(87)58(46-52-14-8-6-9-15-52)72-60(83)24-30-91-32-34-93-36-38-95-40-42-97-44-45-98-43-41-96-39-37-94-35-33-92-31-29-78-48-55(74-75-78)47-70-59(82)17-10-7-13-26-79-61(84)22-23-62(79)85/h6,8-9,14-15,18-23,48,57-58,80H,7,10-13,16-17,24-47,49-51H2,1-5H3,(H,69,88)(H,70,82)(H,71,86)(H,72,83)(H,73,87)/t57-,58-/m0/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|

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Gardenin B is a flavonoid isolated from Baccharis scandens.{{Troriluzole} MedChemExpress|{Troriluzole} Biological Activity|{Troriluzole} In stock|{Troriluzole} manufacturer|{Troriluzole} Epigenetic Reader Domain} Gardenin B induces cell death in human leukemia cells involves multiple caspases.{{Magrolimab} medchemexpress|{Magrolimab} CD47|{Magrolimab} Protocol|{Magrolimab} Purity|{Magrolimab} supplier|{Magrolimab} Cancer} |Product information|CAS Number: 2798-20-1|Molecular Weight: 358.34|Formula: C19H18O7|Chemical Name: 5-hydroxy-6,7,8-trimethoxy-2-(4-methoxyphenyl)-4H-chromen-4-one|Smiles: COC1C=CC(=CC=1)C1=CC(=O)C2=C(O)C(OC)=C(OC)C(OC)=C2O1|InChiKey: LXEVSYZNYDZSOB-UHFFFAOYSA-N|InChi: InChI=1S/C19H18O7/c1-22-11-7-5-10(6-8-11)13-9-12(20)14-15(21)17(23-2)19(25-4)18(24-3)16(14)26-13/h5-9,21H,1-4H3|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : 16.PMID:24580853 67 mg/mL (46.52 mM; Need ultrasonic).|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|

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TP-238 is a potent and selective dual CECR2/BPTF probe with IC50 values of 30 nM and 350 nM, respectively. TP-238 also inhibits BRD9 with a pIC50 of 5.9 and is less active against other 338 kinases.|Product information|CAS Number: 2415263-04-4|Molecular Weight: 458.58|Formula: C22H30N6O3S|Chemical Name: 6-{4-[3-(dimethylamino)propoxy]phenyl}-2-methanesulfonyl-N-[3-(1H-pyrazol-1-yl)propyl]pyrimidin-4-amine|Smiles: CN(C)CCCOC1C=CC(=CC=1)C1=CC(NCCCN2C=CC=N2)=NC(=N1)S(C)(=O)=O|InChiKey: MSIJJXOWLFOYIN-UHFFFAOYSA-N|InChi: InChI=1S/C22H30N6O3S/c1-27(2)13-6-16-31-19-9-7-18(8-10-19)20-17-21(26-22(25-20)32(3,29)30)23-11-4-14-28-15-5-12-24-28/h5,7-10,12,15,17H,4,6,11,13-14,16H2,1-3H3,(H,23,25,26)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{LL-37 amide} web|{LL-37 amide} Bacterial|{LL-37 amide} Epigenetics|{LL-37 amide} Biological Activity|{LL-37 amide} Formula|{LL-37 amide} supplier} |Shelf Life: ≥12 months if stored properly.PMID:28739548 |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|TP-238 has on target biochemical activity of 10-30 nM with CECR2 and 100-350 nM with BPTF. TP-238 displays potency for both CECR2 (pIC50 of 7.5) and BPTF (pIC50 of 6.5) in an Alpha screen assay. Isothermal titration calorimetry (ITC) shows TP-238 with a Kd of 10 nM for CECR2 and 120 nM for BPTF.|Products are for research use only. Not for human use.|

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Dibromochloroacetaldehyde belongs to trihalogenated acetaldehyde and is a byproduct in drinking water. Dibromochloroacetaldehyde has genotoxicity.|Product information|CAS Number: 64316-11-6|Molecular Weight: 236.29|Formula: C2HBr2ClO|Chemical Name: 2,2-dibromo-2-chloroacetaldehyde|Smiles: O=CC(Cl)(Br)Br|InChiKey: SFWAQPWRFZOPKA-UHFFFAOYSA-N|InChi: InChI=1S/C2HBr2ClO/c3-2(4,5)1-6/h1H|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.PMID:24202965 |Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|The rank order of haloacetaldehyde (HAL) cytotoxicity is tribromoacetaldehyde (TBAL)≈chloroacetaldehyde (CAL)>dibromoacetaldehyde (DBAL)≈bromochloroacetaldehyde (BCAL)≈ dibromochloroacetaldehyde (DBCAL)>IAL>bromoacetaldehyde (BAL)≈ bromodichloroacetaldehyde (BDCAL)>dichloroacetaldehyde (DCAL)> trichloroacetaldehyde (TCAL). The HALs are highly cytotoxic compared to other DBP chemical classes. The rank order of HAL genotoxicity is DBAL>CAL≈DBCAL>TBAL≈BAL>BDCAL>BCAL≈DCAL>IAL.|Products are for research use only. Not for human use.|

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1,1,1-Trifluoroethyl-PEG4-propargyl is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.PMID:23341580 |Product information|CAS Number: 1817735-37-7|Molecular Weight: 314.30|Formula: C13H21F3O5|Chemical Name: 1,1,1-trifluoro-3,6,9,12,15-pentaoxaoctadec-17-yne|Smiles: C#CCOCCOCCOCCOCCOCC(F)(F)F|InChiKey: OEQPBBLSVKLHMO-UHFFFAOYSA-N|InChi: InChI=1S/C13H21F3O5/c1-2-3-17-4-5-18-6-7-19-8-9-20-10-11-21-12-13(14,15)16/h1H,3-12H2|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.|Products are for research use only. Not for human use.|

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Amantanium bromide is a quaternary ammonium compound, which is used as an antiseptic/disinfectant for therapeutic fuction.{{Flecainide} web|{Flecainide} Membrane Transporter/Ion Channel|{Flecainide} Technical Information|{Flecainide} In stock|{Flecainide} custom synthesis|{Flecainide} Autophagy} |Product information|CAS Number: 58158-77-3|Molecular Weight: 472.PMID:32695810 54|Formula: C25H46BrNO2|Chemical Name: [2-(adamantane-1-carbonyloxy)ethyl](decyl)dimethylazanium bromide|Smiles: [Br-].CCCCCCCCCC[N+](C)(C)CCOC(=O)C12CC3CC(C1)CC(C2)C3|InChiKey: VSKHGXKMGTVPPY-UHFFFAOYSA-M|InChi: InChI=1S/C25H46NO2.BrH/c1-4-5-6-7-8-9-10-11-12-26(2,3)13-14-28-24(27)25-18-21-15-22(19-25)17-23(16-21)20-25;/h21-23H,4-20H2,1-3H3;1H/q+1;/p-1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|

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Lenacil is a selective uracil substituted herbicide used for control of both annual grasses, broad leafed weeds and some perennial weeds in sugarcane, apples, alfalfa, peaches, peacans, peppermints (Mentha piperita) and sugar beets.{{Vipivotide tetraxetan} web|{Vipivotide tetraxetan} Drug-Linker Conjugates for ADC|{Vipivotide tetraxetan} Biological Activity|{Vipivotide tetraxetan} Description|{Vipivotide tetraxetan} supplier|{Vipivotide tetraxetan} Autophagy} Lenacil can inhibit photosynthesis.|Product information|CAS Number: 2164-08-1|Molecular Weight: 234.{{Adenosine} site|{Adenosine} Endogenous Metabolite|{Adenosine} Technical Information|{Adenosine} Data Sheet|{Adenosine} manufacturer|{Adenosine} Epigenetic Reader Domain} 29|Formula: C13H18N2O2|Chemical Name: 3-cyclohexyl-1H,2H,3H,4H,5H,6H,7H-cyclopenta[d]pyrimidine-2,4-dione|Smiles: O=C1C2CCCC=2NC(=O)N1C1CCCCC1|InChiKey: ZTMKADLOSYKWCA-UHFFFAOYSA-N|InChi: InChI=1S/C13H18N2O2/c16-12-10-7-4-8-11(10)14-13(17)15(12)9-5-2-1-3-6-9/h9H,1-8H2,(H,14,17)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.PMID:34337881 |Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|

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MC-GGFG-DX8951 is a drug-linker conjugate for ADC with antitumor activity by using DX8951 (a DNA topoisomerase I inhibitor), linked via the protease cleavable MC-GGFG linker.PMID:24324376 |Product information|CAS Number: 1600418-29-8|Molecular Weight: 946.97|Formula: C49H51FN8O11|Chemical Name: 6-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)-N-{[({[(1S)-1-[({[(10S,23S)-10-ethyl-18-fluoro-10-hydroxy-19-methyl-5,9-dioxo-8-oxa-4,15-diazahexacyclo[14.7.1.0²,¹⁴.0⁴,¹³.0⁶,¹¹.0²⁰,²⁴]tetracosa-1,6(11),12,14,16,18,20(24)-heptaen-23-yl]carbamoyl}methyl)carbamoyl]-2-phenylethyl]carbamoyl}methyl)carbamoyl]methyl}hexanamide|Smiles: CC1C2CC[C@H](NC(=O)CNC(=O)[C@H](CC3=CC=CC=C3)NC(=O)CNC(=O)CNC(=O)CCCCCN3C(=O)C=CC3=O)C3=C4CN5C(=CC6=C(COC(=O)[C@]6(O)CC)C5=O)C4=NC(=CC=1F)C3=2|InChiKey: XEKFDUNPKACYAY-SODISJPWSA-N|InChi: InChI=1S/C49H51FN8O11/c1-3-49(68)31-19-36-45-29(24-58(36)47(66)30(31)25-69-48(49)67)44-33(14-13-28-26(2)32(50)20-34(56-45)43(28)44)54-40(62)23-53-46(65)35(18-27-10-6-4-7-11-27)55-39(61)22-52-38(60)21-51-37(59)12-8-5-9-17-57-41(63)15-16-42(57)64/h4,6-7,10-11,15-16,19-20,33,35,68H,3,5,8-9,12-14,17-18,21-25H2,1-2H3,(H,51,59)(H,52,60)(H,53,65)(H,54,62)(H,55,61)/t33-,35-,49-/m0/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : 50 mg/mL (52.80 mM; Need ultrasonic).|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|

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GS-9901 is a highly selective and orally active PI3Kδ inhibitor, with an IC50 of 1 nM. Has potential to treat rheumatoid arthritis.|Product information|CAS Number: 1640247-87-5|Molecular Weight: 477.88|Formula: C22H17ClFN9O|Chemical Name: 2,4-diamino-6-{[(S)-[5-chloro-8-fluoro-4-oxo-3-(pyridin-3-yl)-3,4-dihydroquinazolin-2-yl](cyclopropyl)methyl]amino}pyrimidine-5-carbonitrile|Smiles: NC1=NC(N)=C(C#N)C(N[C@@H](C2CC2)C2=NC3=C(F)C=CC(Cl)=C3C(=O)N2C2=CN=CC=C2)=N1|InChiKey: XDSXYMOZKDUASY-INIZCTEOSA-N|InChi: InChI=1S/C22H17ClFN9O/c23-13-5-6-14(24)17-15(13)21(34)33(11-2-1-7-28-9-11)20(30-17)16(10-3-4-10)29-19-12(8-25)18(26)31-22(27)32-19/h1-2,5-7,9-10,16H,3-4H2,(H5,26,27,29,31,32)/t16-/m0/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vivo:|GS-9901 (0.3/1/3 mg/kg, orally, twice daily for 7 days) demonstrates efficacy in a rat model of arthritis and is predicted to be suitable for q.d. dosing in humans.|Products are for research use only. Not for human use.|

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Tiotropium bromide is a long-acting, 24-hour, anticholinergic bronchodilator used in the management of chronic obstructive pulmonary disease (COPD).{{Canagliflozin} MedChemExpress|{Canagliflozin} SGLT|{Canagliflozin} Purity & Documentation|{Canagliflozin} Description|{Canagliflozin} custom synthesis|{Canagliflozin} Autophagy} Tiotropium is a muscarinic receptor antagonist, often referred to as an antimuscarinic or anticholinergic agent.{{Grazoprevir} site|{Grazoprevir} Anti-infection|{Grazoprevir} Purity & Documentation|{Grazoprevir} Data Sheet|{Grazoprevir} supplier|{Grazoprevir} Autophagy} Although it does not display selectivity for specific muscarinic receptors, when topically applied it acts mainly on M3 muscarinic receptors[7] located on smooth muscle cells and submucosal glands.PMID:24631563 This leads to a reduction in smooth muscle contraction and mucus secretion and thus produces a bronchodilatory effect.|Product information|CAS Number: 136310-93-5|Molecular Weight: 472.42|Formula: C19H22BrNO4S2|Chemical Name: (1R,2R,4S,5S)-7-{[2-hydroxy-2,2-bis(thiophen-2-yl)acetyl]oxy}-9,9-dimethyl-3-oxa-9-azatricyclo[3.3.1.0²,⁴]nonan-9-ium bromide|Smiles: [Br-].C[N+]1(C)[C@@H]2CC(C[C@H]1[C@@H]1O[C@H]21)OC(=O)C(O)(C1=CC=CS1)C1=CC=CS1|InChiKey: DQHNAVOVODVIMG-RGECMCKFSA-M|InChi: InChI=1S/C19H22NO4S2.BrH/c1-20(2)12-9-11(10-13(20)17-16(12)24-17)23-18(21)19(22,14-5-3-7-25-14)15-6-4-8-26-15;/h3-8,11-13,16-17,22H,9-10H2,1-2H3;1H/q+1;/p-1/t11?,12-,13+,16-,17+;|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥360 days if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|

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MK8033 is a selective small-molecule inhibitor, ATP competitive. Phase I investigation of the cMet inhibitor MK-8033 is ongoing. Plans include a trial of this agent in refractory colorectal cancer, with pre- and post-treatment biopsies to evaluate for relevant molecular signatures.|Product information|CAS Number: 1001917-37-8|Molecular Weight: 471.PMID:29844565 53|Formula: C25H21N5O3S|Synonym:|MK-8033|MK 8033|MK8033|Chemical Name: 1-[5-(1-methyl-1H-pyrazol-4-yl)-2-oxo-7-azatricyclo[9.4.0.0³,⁸]pentadeca-1(11),3(8),4,6,9,12,14-heptaen-14-yl]-N-[(pyridin-2-yl)methyl]methanesulfonamide|Smiles: CN1C=C(C=N1)C1=CC2=C(C=CC3=CC=C(CS(=O)(=O)NCC4=CC=CC=N4)C=C3C2=O)N=C1|InChiKey: VMJFTOSOFDEKTM-UHFFFAOYSA-N|InChi: InChI=1S/C25H21N5O3S/c1-30-15-20(13-28-30)19-11-23-24(27-12-19)8-7-18-6-5-17(10-22(18)25(23)31)16-34(32,33)29-14-21-4-2-3-9-26-21/h2-13,15,29H,14,16H2,1H3|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥360 days if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|

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3-O-Methyldopa (3-Methoxy-L-tyrosine) is a metabolite of L-DOPA which is formed by catechol-O-methyltransferase (COMT). 3-O-Methyldopa competitively inhibits the pharmacodynamics of l-DOPA and dopamine.|Product information|CAS Number: 300-48-1|Molecular Weight: 211.21|Formula: C10H13NO4|Chemical Name: (2S)-2-amino-3-(4-hydroxy-3-methoxyphenyl)propanoic acid|Smiles: COC1=CC(C[C@H](N)C(O)=O)=CC=C1O|InChiKey: PFDUUKDQEHURQC-ZETCQYMHSA-N|InChi: InChI=1S/C10H13NO4/c1-15-9-5-6(2-3-8(9)12)4-7(11)10(13)14/h2-3,5,7,12H,4,11H2,1H3,(H,13,14)/t7-/m0/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: H2O : 16.{{Ulixertinib} web|{Ulixertinib} Stem Cell/Wnt|{Ulixertinib} Technical Information|{Ulixertinib} References|{Ulixertinib} supplier|{Ulixertinib} Autophagy} 67 mg/mL (78.{{Zandelisib} medchemexpress|{Zandelisib} PI3K/Akt/mTOR|{Zandelisib} Protocol|{Zandelisib} Data Sheet|{Zandelisib} manufacturer|{Zandelisib} Epigenetic Reader Domain} 93 mM; Need ultrasonic).PMID:34645436 |Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|

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BIO5192 is a selective and potent integrin α4β1 (VLA-4) inhibitor (KdProduct information|CAS Number: 327613-57-0|Molecular Weight: 817.78|Formula: C38H46Cl2N6O8S|Chemical Name: (2S)-2-{[(2S)-1-(3,5-dichlorobenzenesulfonyl)pyrrolidin-2-yl]formamido}-4-[(2S)-4-methyl-2-[N-methyl-2-(4-{[(2-methylphenyl)carbamoyl]amino}phenyl)acetamido]pentanamido]butanoic acid|Smiles: CN([C@@H](CC(C)C)C(=O)NCC[C@H](NC(=O)[C@@H]1CCCN1S(=O)(=O)C1C=C(Cl)C=C(Cl)C=1)C(O)=O)C(=O)CC1C=CC(=CC=1)NC(=O)NC1=CC=CC=C1C|InChiKey: MNQBPRHHZPXCKZ-ZDCRTTOTSA-N|InChi: InChI=1S/C38H46Cl2N6O8S/c1-23(2)18-33(45(4)34(47)19-25-11-13-28(14-12-25)42-38(52)44-30-9-6-5-8-24(30)3)35(48)41-16-15-31(37(50)51)43-36(49)32-10-7-17-46(32)55(53,54)29-21-26(39)20-27(40)22-29/h5-6,8-9,11-14,20-23,31-33H,7,10,15-19H2,1-4H3,(H,41,48)(H,43,49)(H,50,51)(H2,42,44,52)/t31-,32-,33-/m0/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.PMID:23613863 |Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vivo:|The combination of BIO5192 (1 mg/kg; i.v.) and Plerixafor (5 mg/kg; s.c.) exert an additive effect on progenitor mobilization. BIO5192 (30 mg/kg; s.c; bid; during days 5 through 14) delays paralysis associated with EAE (experimental autoimmune encephalomyelitis). BIO5192 (1 mg/kg, i.v.) shows the terminal half-life is 1.1 hours. BIO5192 (3, 10, and 30 mg/kg; s.c.) shows half-lives of 1.7, 2.7, and 4.7 hours, respectively. The blood plasma curves show that the AUC for the s.c. route of administration increased about 2.5-fold from 5,460 h*ng/ml for the 3 mg/kg dose to 14,175 h*ng/ml for the 30 mg/kg.|Products are for research use only. Not for human use.|

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Escitalopram is an antidepressant of the selective serotonin reuptake inhibitor (SSRI) class.|Product information|CAS Number: 128196-01-0|Molecular Weight: 324.39|Formula: C20H21FN2O|Chemical Name: (1S)-1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile|Smiles: CN(C)CCC[C@]1(OCC2=CC(=CC=C12)C#N)C1C=CC(F)=CC=1|InChiKey: WSEQXVZVJXJVFP-FQEVSTJZSA-N|InChi: InChI=1S/C20H21FN2O/c1-23(2)11-3-10-20(17-5-7-18(21)8-6-17)19-9-4-15(13-22)12-16(19)14-24-20/h4-9,12H,3,10-11,14H2,1-2H3/t20-/m0/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥360 days if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|

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AM-2394 is a structurally distinct glucokinase activator (GKA). AM-2394 activates glucokinase (GK) with an EC50 of 60 nM.|Product information|CAS Number: 1442684-77-6|Molecular Weight: 423.47|Formula: C22H25N5O4|Chemical Name: 1-[6′-(2-hydroxy-2-methylpropoxy)-4-[(5-methylpyridin-3-yl)oxy]-[3,3′-bipyridin]-6-yl]-3-methylurea|Smiles: CC1C=C(C=NC=1)OC1C=C(NC(=O)NC)N=CC=1C1C=NC(=CC=1)OCC(C)(C)O|InChiKey: QUISANLDBDCMPD-UHFFFAOYSA-N|InChi: InChI=1S/C22H25N5O4/c1-14-7-16(11-24-9-14)31-18-8-19(27-21(28)23-4)25-12-17(18)15-5-6-20(26-10-15)30-13-22(2,3)29/h5-12,29H,13H2,1-4H3,(H2,23,25,27,28)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : ≥ 30 mg/mL (70.84 mM).|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.PMID:28739548 |Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vivo:|AM-2394, a structurally distinct glucokinase activator that displays a robust reduction in plasma glucose during an oral glucose tolerance test (OGTT) in ob/ob mice at a dose of 3 mg/kg. AM-2394 increases the affinity of glucokinase (GK) for glucose by approximately 10-fold, exhibits moderate clearance and good oral bioavailability in multiple animal models, and lowers glucose excursion following an oral glucose tolerance test in an ob/ob mouse model of diabetes. AM-2394 exhibits good-to-moderate cross species plasma clearance, volume of distribution, and oral bioavailability, allowing for further evaluation in animal models.|Products are for research use only. Not for human use.|

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Myristicin (Myristicine), a terpene-like active component in Nutmeg which is the seed of Myristica fragrans, is a weak inhibitor of monamine oxidase (MAO) and a mechanism-based inhibitor of CYP1A2.|Product information|CAS Number: 607-91-0|Molecular Weight: 192.21|Formula: C11H12O3|Chemical Name: 4-methoxy-6-(prop-2-en-1-yl)-2H-1, 3-benzodioxole|Smiles: COC1=CC(CC=C)=CC2OCOC1=2|InChiKey: BNWJOHGLIBDBOB-UHFFFAOYSA-N|InChi: InChI=1S/C11H12O3/c1-3-4-8-5-9(12-2)11-10(6-8)13-7-14-11/h3,5-6H,1,4,7H2,2H3|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: Solubility (25°C).|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|

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Trypan Blue (Visionblue, Diphenyl Blue, Direct Blue 14) is a colorimetric dye that stains dead cells with a blue color easily observed using light microscopy at low resolution.|Product information|CAS Number: 72-57-1|Molecular Weight: 960.81|Formula: C34H24N6Na4O14S4|Chemical Name: tetrasodium;5-amino-3-[[4-[4-[(8-amino-1-hydroxy-3, 6-disulfonatonaphthalen-2-yl)diazenyl]-3-methylphenyl]-2-methylphenyl]diazenyl]-4-hydroxynaphthalene-2, 7-disulfonate|Smiles: [Na+].{{Tegoprubart} site|{Tegoprubart} Purity & Documentation|{Tegoprubart} Description|{Tegoprubart} supplier|{Tegoprubart} Epigenetic Reader Domain} [Na+].[Na+].[Na+].CC1C=C(C=CC=1N=NC1=C(C=C2C=C(C=C(N)C2=C1O)S([O-])(=O)=O)S([O-])(=O)=O)C1C=C(C)C(=CC=1)N=NC1=C(C=C2C=C(C=C(N)C2=C1O)S([O-])(=O)=O)S([O-])(=O)=O|InChiKey: GLNADSQYFUSGOU-GPTZEZBUSA-J|InChi: InChI=1S/C34H28N6O14S4.PMID:23618405 4Na/c1-15-7-17(3-5-25(15)37-39-31-27(57(49,50)51)11-19-9-21(55(43,44)45)13-23(35)29(19)33(31)41)18-4-6-26(16(2)8-18)38-40-32-28(58(52,53)54)12-20-10-22(56(46,47)48)14-24(36)30(20)34(32)42;;;;/h3-14,41-42H,35-36H2,1-2H3,(H,43,44,45)(H,46,47,48)(H,49,50,51)(H,52,53,54);;;;/q;4*+1/p-4/b39-37+,40-38+;;;;|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: Solubility (25°C). 100 mg/mL(104.07 mM). 100 mg/mL(104.07 mM).|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|

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Ethyl ferulate, a naturally lipophilic derivative of ferulic acid originally derived from giant fennel (F. communis), induces heme oxygenase-1 (HO-1) and protects rat neurons against oxidative stress. Ethyl ferulate also protects neurons against amyloid β peptide (1-42)-induced oxidative stress and neurotoxicity.|Product information|CAS Number: 4046-02-0|Molecular Weight: 222.24|Formula: C12H14O4|Chemical Name: ethyl (2E)-3-(4-hydroxy-3-methoxyphenyl)prop-2-enoate|Smiles: COC1=CC(/C=C/C(=O)OCC)=CC=C1O|InChiKey: ATJVZXXHKSYELS-FNORWQNLSA-N|InChi: InChI=1S/C12H14O4/c1-3-16-12(14)7-5-9-4-6-10(13)11(8-9)15-2/h4-8,13H,3H2,1-2H3/b7-5+|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : ≥ 100 mg/mL (449.96 mM).|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|References:|Scapagnini G, et al. Ethyl ferulate, a lipophilic polyphenol, induces HO-1 and protects rat neurons against oxidative stress. Antioxid Redox Signal. 2004 Oct;6(5):811-8.Sultana R, et al. Ferulic acid ethyl ester protects neurons against amyloid beta- peptide(1-42)-induced oxidative stress and neurotoxicity: relationship to antioxidant activity. J Neurochem. 2005 Feb;92(4):749-58.Products are for research use only. Not for human use.|

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Phenethyl alcohol (2-phenylethanol, 2-Phenylethyl alcohol, Benzeneethanol, Phenylethanol) is an antimicrobial, antiseptic, and disinfectant that is used also as an aromatic essence and preservative in pharmaceutics and perfumery.|Product information|CAS Number: 60-12-8|Molecular Weight: 122.{{Quizartinib} site|{Quizartinib} Apoptosis|{Quizartinib} Purity & Documentation|{Quizartinib} In Vitro|{Quizartinib} custom synthesis|{Quizartinib} Cancer} 16|Formula: C8H10O|Synonym:|Phenylethyl alcohol|Phenethyl alcohol|Benzyl carbinol|Chemical Name: 2-phenylethan-1-ol|Smiles: OCCC1C=CC=CC=1|InChiKey: WRMNZCZEMHIOCP-UHFFFAOYSA-N|InChi: InChI=1S/C8H10O/c9-7-6-8-4-2-1-3-5-8/h1-5,9H,6-7H2|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: Solubility (25°C).{{Doxazosin} web|{Doxazosin} Autophagy|{Doxazosin} Purity & Documentation|{Doxazosin} In stock|{Doxazosin} supplier|{Doxazosin} Epigenetics} |Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.PMID:24563649 |Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|Phenethyl alcohol has been shown to interact with the cytoplasmic membrane of other microorganisms in various ways. Escherichia coli phenethyl alcohol, at a concentration higher than that used to induce myxospore formation, inhibits growth by causing a breakdown in the cellular permeabihty barrier. At lower concentrations, phospholipid synthesis, uptake of gentian violet in E. coli and the uptake of several amino acids by Neurospora crassa were all inhibited by phenethyl alcohol.|References:|Lingappa BT, et al. Phenethyl alcohol and tryptophol: autoantibiotics produced by the fungus Candida albicans. Science. 1969 Jan 10;163(3863):192-4.Products are for research use only. Not for human use.|

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Lanraplenib monosuccinate (GS-9876 monosuccinate) is a highly selective and orally active SYK inhibitor (IC50=9.5 nM) in development for the treatment of inflammatory diseases. Lanraplenib monosuccinate (GS-9876 monosuccinate) inhibits SYK activity in platelets via the glycoprotein VI (GPVI) receptor without prolonging bleeding time (BT) in monkeys or humans.|Product information|CAS Number: 1800046-97-2|Molecular Weight: 561.59|Formula: C27H31N9O5|Chemical Name: 6-[8-({4-[4-(oxetan-3-yl)piperazin-1-yl]phenyl}amino)imidazo[1,2-a]pyrazin-6-yl]pyrazin-2-amine; butanedioic acid|Smiles: NC1=CN=CC(=N1)C1=CN2C=CN=C2C(NC2C=CC(=CC=2)N2CCN(CC2)C2COC2)=N1.{{Vobramitamab} medchemexpress|{Vobramitamab} Antibody-drug Conjugate/ADC Related|{Vobramitamab} Technical Information|{Vobramitamab} Purity|{Vobramitamab} custom synthesis|{Vobramitamab} Autophagy} OC(=O)CCC(O)=O|InChiKey: DVFRSTNNWJHWGW-UHFFFAOYSA-N|InChi: InChI=1S/C23H25N9O.{{Isoniazid} web|{Isoniazid} Autophagy|{Isoniazid} Biological Activity|{Isoniazid} References|{Isoniazid} supplier|{Isoniazid} Cancer} C4H6O4/c24-21-12-25-11-19(28-21)20-13-32-6-5-26-23(32)22(29-20)27-16-1-3-17(4-2-16)30-7-9-31(10-8-30)18-14-33-15-18;5-3(6)1-2-4(7)8/h1-6,11-13,18H,7-10,14-15H2,(H2,24,28)(H,27,29);1-2H2,(H,5,6)(H,7,8)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : 125 mg/mL (222.PMID:23522542 58 mM; Need ultrasonic).|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|Lanraplenib monosuccinate (GS-9876 monosuccinate) inhibits anti-IgM stimulated phosphorylation of AKT, BLNK, BTK, ERK, MEK, and PKCδ in human B cells with EC50 values of 24-51 nM. Lanraplenib monosuccinate inhibits anti-IgM mediated CD69 and CD86 expression on B-cells (EC50=112±10 nM and 164±15 nM, respectively) and anti-IgM /anti-CD40 co-stimulated B cell proliferation (EC50=108±55 nM). In human macrophages, Lanraplenib monosuccinate inhibits IC-stimulated TNFα and IL-1β release (EC50=121±77 nM and 9±17 nM, respectively). Lanraplenib monosuccinate (GS-9876 monosuccinate) inhibits glycoprotein VI (GPVI)-induced phosphorylation of linker for activation of T cells and phospholipase Cγ2, platelet activation and aggregation in human whole blood, and platelet binding to collagen under arterial flow.|Products are for research use only. Not for human use.|

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Pifithrin-alpha is a p53 inactivator.{{Farletuzumab ecteribulin} MedChemExpress|{Farletuzumab ecteribulin} Antibody-drug Conjugate/ADC Related|{Farletuzumab ecteribulin} Technical Information|{Farletuzumab ecteribulin} References|{Farletuzumab ecteribulin} supplier|{Farletuzumab ecteribulin} Autophagy} It also has neuroprotective activity against strokes.PMID:24732841 |Product information|CAS Number: 63208-82-2|Molecular Weight: 367.30|Formula: C16H19BrN2OS|Chemical Name: 2-(2-imino-2,3,4,5,6,7-hexahydro-1,3-benzothiazol-3-yl)-1-(4-methylphenyl)ethan-1-one hydrobromide|Smiles: Br.CC1C=CC(=CC=1)C(=O)CN1C(=N)SC2CCCCC1=2|InChiKey: HAGVCKULCLQGRF-UHFFFAOYSA-N|InChi: InChI=1S/C16H18N2OS.BrH/c1-11-6-8-12(9-7-11)14(19)10-18-13-4-2-3-5-15(13)20-16(18)17;/h6-9,17H,2-5,10H2,1H3;1H|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥360 days if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|

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Monoacylglycerol lipase inhibitor 1 is a potent monoacylglycerol lipase inhibitor (compound 13).|Product information|CAS Number: 2714570-98-4|Molecular Weight: 356.46|Formula: C21H28N2O3|Smiles: CC(C)C1C=CC(=CC=1)[C@@H]1C[C@@H](C1)N(C)C(=O)[C@@H]1C[C@@]2(COC(=O)N2)C1|InChiKey: BKAUVVYBHJYFLY-BXCOXIEISA-N|InChi: InChI=1S/C21H28N2O3/c1-13(2)14-4-6-15(7-5-14)16-8-18(9-16)23(3)19(24)17-10-21(11-17)12-26-20(25)22-21/h4-7,13,16-18H,8-12H2,1-3H3,(H,22,25)/t16-,17-,18+,21+|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: To be determined|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|References:|Ram W Sabnis, et al. Novel Aminocyclobutanes as Monoacylglycerol Lipase Modulators. ACS Med Chem Lett. 2022 Feb 1;13(2):162-163.Products are for research use only. Not for human use.|

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GDC-1971 (compound 199) is a SHP2 inhibitor.|Product information|CAS Number: 2377352-49-1|Molecular Weight: 454.53|Formula: C25H26N8O|Smiles: N[C@@H]1C2=CC=CC=C2OC21CCN(CC2)C1=CN=C2C(NN=C2N2CCCC3=NC=CC=C23)=N1|InChiKey: RGCGBFIARQENML-JOCHJYFZSA-N|InChi: InChI=1S/C25H26N8O/c26-22-16-5-1-2-8-19(16)34-25(22)9-13-32(14-10-25)20-15-28-21-23(29-20)30-31-24(21)33-12-4-6-17-18(33)7-3-11-27-17/h1-3,5,7-8,11,15,22H,4,6,9-10,12-14,26H2,(H,29,30,31)/t22-/m1/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: To be determined|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|References:|Alexander M, et al. Shp2 phosphatase inhibitors and methods of use thereof. Patent WO2019183367A1.Products are for research use only. Not for human use.|

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(R, S)-CFT8634 is a selective and orally active BRD9 protein degrader. (R, S)-CFT8634 has the potential for the research of disorders mediated by BRD9, including but not limited to abnormal cellular proliferation (extracted from patent WO2021178920A1, compound 176). (R, S)-CFT8634 is a selective and orally active BRD9 protein degrader. (R, S)-CFT8634 has the potential for the research of disorders mediated by BRD9, including but not limited to abnormal cellular proliferation (extracted from patent WO2021178920A1, compound 176)[1].|Product information|CAS Number: 2704619-11-2|Molecular Weight: 710.79|Formula: C37H45F3N6O5|Smiles: CN1C=C(C2C=C(OC)C(CN3CC(F)(F)[C@@H](CC3)N3CCN(CC3)C3=CC=C(C=C3F)N[C@H]3CCC(=O)NC3=O)=C(C=2)OC)C(C)=C(C)C1=O|InChiKey: GNRGNRCQXHMQQV-RYCFQHDISA-N|InChi: InChI=1S/C37H45F3N6O5/c1-22-23(2)36(49)43(3)19-26(22)24-16-31(50-4)27(32(17-24)51-5)20-44-11-10-33(37(39,40)21-44)46-14-12-45(13-15-46)30-8-6-25(18-28(30)38)41-29-7-9-34(47)42-35(29)48/h6,8,16-19,29,33,41H,7,9-15,20-21H2,1-5H3,(H,42,47,48)/t29-,33+/m0/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: To be determined|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|

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MIPS-521 is a positive allosteric modulator of the A1R, exhibits analgesic efficacy in rats in vivo through modulation of the increased levels of endogenous adenosine that occur in the spinal cord of rats with neuropathic pain. We also report the structure of the A1R co-bound to adenosine, MIPS521 and a Gi2 heterotrimer, revealing an extrahelical lipid-detergent-facing allosteric binding pocket that involves transmembrane helixes 1, 6 and 7. Molecular dynamics simulations and ligand kinetic binding experiments support a mechanism whereby MIPS521 stabilizes the adenosine-receptor-G protein complex.|Product information|CAS Number: 1146188-19-3|Molecular Weight: 449.80|Formula: C19H10ClF6NOS|Chemical Name: 4-[3, 5-bis(trifluoromethyl)phenyl]-3-(4-chlorobenzoyl)thiophen-2-amine|Smiles: NC1SC=C(C=1C(=O)C1C=CC(Cl)=CC=1)C1C=C(C=C(C=1)C(F)(F)F)C(F)(F)F|InChiKey: IVHJBJJHYFIUOA-UHFFFAOYSA-N|InChi: InChI=1S/C19H10ClF6NOS/c20-13-3-1-9(2-4-13)16(28)15-14(8-29-17(15)27)10-5-11(18(21,22)23)7-12(6-10)19(24,25)26/h1-8H,27H2|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: To be determined|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Vigabatrin} site|{Vigabatrin} Neuronal Signaling|{Vigabatrin} Protocol|{Vigabatrin} Purity|{Vigabatrin} custom synthesis|{Vigabatrin} Autophagy} |Shelf Life: ≥12 months if stored properly.{{Estramustine phosphate} web|{Estramustine phosphate} Cytoskeleton|{Estramustine phosphate} Protocol|{Estramustine phosphate} In Vivo|{Estramustine phosphate} custom synthesis|{Estramustine phosphate} Autophagy} |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.PMID:23819239 |Drug Formulation: To be determined|HS Tariff Code: 382200|References:|Draper-Joyce CJ, Bhola R, Wang J, Bhattarai A, Nguyen ATN, Cowie-Kent I, O’Sullivan K, Chia LY, Venugopal H, Valant C, Thal DM, Wootten D, Panel N, Carlsson J, Christie MJ, White PJ, Scammells P, May LT, Sexton PM, Danev R, Miao Y, Glukhova A, Imlach WL, Christopoulos A. Positive allosteric mechanisms of adenosine A1 receptor-mediated analgesia. Nature. 2021 Sep;597(7877):571-576.Products are for research use only. Not for human use.|

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SM-276001 is a potent selective TLR7 agonist that can induce antitumor immune responses. SM-276001 is an orally active interferon (IFN) inducer.|Product information|CAS Number: 473930-22-2|Molecular Weight: 327.38|Formula: C16H21N7O|Chemical Name: 6-amino-2-(butylamino)-9-[(6-methylpyridin-3-yl)methyl]-8,9-dihydro-7H-purin-8-one|Smiles: CC1=CC=C(CN2C(=O)NC3=C(N)N=C(NCCCC)N=C23)C=N1|InChiKey: UEIOLEMXCBOQAX-UHFFFAOYSA-N|InChi: InChI=1S/C16H21N7O/c1-3-4-7-18-15-21-13(17)12-14(22-15)23(16(24)20-12)9-11-6-5-10(2)19-8-11/h5-6,8H,3-4,7,9H2,1-2H3,(H,20,24)(H3,17,18,21,22)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : 125 mg/mL (381.82 mM; Need ultrasonic).|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.{{Sarolaner} medchemexpress|{Sarolaner} Anti-infection|{Sarolaner} Biological Activity|{Sarolaner} Description|{Sarolaner} manufacturer|{Sarolaner} Epigenetics} |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.{{Coelenterazine} site|{Coelenterazine} NF-κB|{Coelenterazine} Biological Activity|{Coelenterazine} Description|{Coelenterazine} custom synthesis|{Coelenterazine} Cancer} |Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|SM-276001 (1 nM-10 μM) dose-dependently activates NF-κB through human TLR7.PMID:23672196 |In Vivo:|SM-276001 demonstrates potent IFN-inducing activity at a dose of 0.1 mg/kg by oral administration in mice. Oral administration of SM-276001, leads to the induction of an inflammatory cytokine and chemokine milieu and to the activation of a diverse population of immune effector cells including T and B lymphocytes, NK and NKT cells. SM-276001 (3 mg/kg PO biweekly) significantly inhibits tumor growth in the Renca renal cell cancer and CT26 colorectal models. SM-276001 (orally; 0.1, 1 or 10 mg/kg) leads to the activation of a diverse population of spleen-resident immune effector cells in Balb/c and C57BL/6J mice. When administered at 1 mg/kg or greater, the plasma concentration of SM-276001 exceeds the MEC of 30 nM.|Products are for research use only. Not for human use.|

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GGTI-2418 is a highly potent, competitive, and selective geranylgeranyltransferase I (GGTase I) inhibitor. GGTI-2418 inhibits GGTase I and FTase activities with IC50s of 9.5 nM and 53 μM, respectively. GGTI-2418 also increases p27(Kip1) and induces significant regression of breast tumors.|Product information|CAS Number: 501010-06-6|Molecular Weight: 441.52|Formula: C23H31N5O4|Chemical Name: (2S)-2-{[(2S)-2-benzyl-4-[(5-methyl-1H-imidazol-4-yl)methyl]-3-oxopiperazine-1-carbonyl]amino}-4-methylpentanoic acid|Smiles: CC1NC=NC=1CN1CCN([C@@H](CC2C=CC=CC=2)C1=O)C(=O)N[C@@H](CC(C)C)C(O)=O|InChiKey: COLCNDRDBCLVOC-ICSRJNTNSA-N|InChi: InChI=1S/C23H31N5O4/c1-15(2)11-18(22(30)31)26-23(32)28-10-9-27(13-19-16(3)24-14-25-19)21(29)20(28)12-17-7-5-4-6-8-17/h4-8,14-15,18,20H,9-13H2,1-3H3,(H,24,25)(H,26,32)(H,30,31)/t18-,20-/m0/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : 125 mg/mL (283.11 mM; Need ultrasonic).|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|GGTI-2418 inhibits GGTase I and FTase activities with IC50s of 9.{{Lebrikizumab} site|{Lebrikizumab} Interleukin Related|{Lebrikizumab} Biological Activity|{Lebrikizumab} Purity|{Lebrikizumab} supplier|{Lebrikizumab} Epigenetics} 5±2.{{Adapalene} site|{Adapalene} Apoptosis|{Adapalene} Technical Information|{Adapalene} Formula|{Adapalene} manufacturer|{Adapalene} Epigenetics} 0 nM and 53±11 μM, respectively, a 5,600-fold selectivity toward inhibition of GGTase I versus FTase.PMID:24423657 GGTI-2418 demonstrates competitive inhibition of GGTase I against the H-Ras-CVLL protein with a Ki of 4.4±1.6 nM. GGTi-2418 (10-15 μM; 16 hours) treatment delocalizes FBXL2 and stabilizes IP3R3.|In Vivo:|GGTI-2418 (100 mg/kg daily or 200 mg/kg every third day; 15 days) significantly inhibits the growth of breast tumor xenografts in nude mice with MDA-MB-231 xenografts. GGTI-2418 (100 mg/kg daily; 5 days) induces regression of ErbB2-driven mammary tumors in ErbB2 transgenic mice. GGTI-2418 inhibits the geranylgeranylation of Rap1 and causes a dramatic decrease in S473 phosphorylation of Akt. GGTI-2418 also upregulates p27 levels in vivo.|Products are for research use only. Not for human use.|

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Sulfo-ara-F-NMN (CZ-48) is a mimetic of nicotinamide mononucleotide (NMN). Sulfo-ara-F-NMN acts selectively, activating SARM1 but inhibiting CD38 (IC50 around 10 μM). Sulfo-ara-F-NMN induces intracellular cyclic ADP-ribose (cADPR) production.|Product information|CAS Number: 1374663-29-2|Molecular Weight: 352.28|Formula: C11H14FN2O6PS|Chemical Name: 3-carbamoyl-1-[(2R,3S,4R,5R)-3-fluoro-4-hydroxy-5-({[hydroxy(oxido)sulfanylidene-λ⁵-phosphanyl]oxy}methyl)oxolan-2-yl]-1λ⁵-pyridin-1-ylium|Smiles: NC(=O)C1C=[N+](C=CC=1)[C@@H]1O[C@H](COP([O-])(O)=S)[C@@H](O)[C@@H]1F|InChiKey: SIQYQBAPGWSZQF-PKIKSRDPSA-N|InChi: InChI=1S/C11H14FN2O6PS/c12-8-9(15)7(5-19-21(17,18)22)20-11(8)14-3-1-2-6(4-14)10(13)16/h1-4,7-9,11,15H,5H2,(H3-,13,16,17,18,22)/t7-,8+,9-,11-/m1/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : 200 mg/mL (567.{{Nystatin} medchemexpress|{Nystatin} Apoptosis|{Nystatin} Protocol|{Nystatin} In Vitro|{Nystatin} supplier|{Nystatin} Cancer} 73 mM; Need ultrasonic).{{Lansoprazole} web|{Lansoprazole} Membrane Transporter/Ion Channel|{Lansoprazole} Protocol|{Lansoprazole} In Vivo|{Lansoprazole} custom synthesis|{Lansoprazole} Epigenetic Reader Domain} |Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.PMID:22664133 |Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|Sterile alpha and Toll/interleukin-1 receptor motif-containing 1 (SARM1) is an adaptor protein in the Toll-like receptor pathway. Sulfo-ara-F-NMN activates SARM1 to produce cyclic ADP-ribose and induces non-apoptotic cell death.|Products are for research use only. Not for human use.|

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TFAX 568, SE is an orange fluorescent dye and exhibits pH-insensitivity over a very broad range (pH in the 4-10).{{Pretomanid} web|{Pretomanid} Bacterial|{Pretomanid} Purity & Documentation|{Pretomanid} In Vivo|{Pretomanid} custom synthesis|{Pretomanid} Cancer} TFAX 568, SE yields exceptionally bright, photostable conjugates with proteins or antibodies (such as goat anti-mouse IgG).|Product information|CAS Number: 878549-44-1|Molecular Weight: 791.80|Formula: C37H33N3O13S2|Chemical Name: 6-(2-carboxy-4-{[(2,5-dioxopyrrolidin-1-yl)oxy]carbonyl}phenyl)-2,2,10,10-tetramethyl-4-(sulfomethyl)-8-(sulfonatomethyl)-2,10-dihydro-1H-13-oxa-1,11-diazapentacen-11-ium|Smiles: CC1(C)C=C(CS(O)(=O)=O)C2=CC3=C(C=C2N1)OC1=CC2=[NH+]C(C)(C)C=C(CS([O-])(=O)=O)C2=CC1=C3C1=CC=C(C=C1C(O)=O)C(=O)ON1C(=O)CCC1=O|InChiKey: DJLBKHHGFYXTRY-UHFFFAOYSA-N|InChi: InChI=1S/C37H33N3O13S2/c1-36(2)14-19(16-54(46,47)48)22-10-25-29(12-27(22)38-36)52-30-13-28-23(20(17-55(49,50)51)15-37(3,4)39-28)11-26(30)33(25)21-6-5-18(9-24(21)34(43)44)35(45)53-40-31(41)7-8-32(40)42/h5-6,9-15,38H,7-8,16-17H2,1-4H3,(H,43,44)(H,46,47,48)(H,49,50,51)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Sacubitril} site|{Sacubitril} Neprilysin|{Sacubitril} Protocol|{Sacubitril} Purity|{Sacubitril} supplier|{Sacubitril} Epigenetic Reader Domain} |Shelf Life: ≥12 months if stored properly.PMID:28038441 |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|Excitation maximum=560±20 nm; emission maximum=610±20 nm. Proteins labeled with the TFAX 568 dye is several-fold brighter than the same proteins labeled with lissamine rhodamine B dye.|Products are for research use only. Not for human use.|

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Fmoc-N-methyl-PEG3-CH2CH2COOH is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Fmoc-N-methyl-PEG3-CH2CH2COOH is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.|Product information|CAS Number: 1807518-77-9|Molecular Weight: 457.52|Formula: C25H31NO7|Chemical Name: 3-(2-{2-[2-({[(9H-fluoren-9-yl)methoxy]carbonyl}(methyl)amino)ethoxy]ethoxy}ethoxy)propanoic acid|Smiles: CN(CCOCCOCCOCCC(O)=O)C(=O)OCC1C2=CC=CC=C2C2=CC=CC=C21|InChiKey: JKEBDIJQSKVIID-UHFFFAOYSA-N|InChi: InChI=1S/C25H31NO7/c1-26(11-13-31-15-17-32-16-14-30-12-10-24(27)28)25(29)33-18-23-21-8-4-2-6-19(21)20-7-3-5-9-22(20)23/h2-9,23H,10-18H2,1H3,(H,27,28)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Fmoc-Asn(Trt)-OH} site|{Fmoc-Asn(Trt)-OH} {Biochemical Assay Reagents}|{Fmoc-Asn(Trt)-OH} Biological Activity|{Fmoc-Asn(Trt)-OH} In Vivo|{Fmoc-Asn(Trt)-OH} manufacturer|{Fmoc-Asn(Trt)-OH} Epigenetics} |Shelf Life: ≥12 months if stored properly.PMID:23756629 |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.|Products are for research use only. Not for human use.|

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Bis-PEG10-acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.|Product information|CAS Number: 2055023-26-0|Molecular Weight: 558.61|Formula: C24H46O14|Chemical Name: 4,7,10,13,16,19,22,25,28,31-decaoxatetratriacontanedioic acid|Smiles: OC(=O)CCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCC(O)=O|InChiKey: PPYUGGOOBJIZHK-UHFFFAOYSA-N|InChi: InChI=1S/C24H46O14/c25-23(26)1-3-29-5-7-31-9-11-33-13-15-35-17-19-37-21-22-38-20-18-36-16-14-34-12-10-32-8-6-30-4-2-24(27)28/h1-22H2,(H,25,26)(H,27,28)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.PMID:32180353 |Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.|Products are for research use only. Not for human use.|

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N-(Mal-PEG6)-N-bis(PEG7-TCO) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.PMID:23916866 |Product information|CAS Number: 2093152-84-0|Molecular Weight: 1652.95|Formula: C78H137N7O30|Chemical Name: cyclooct-4-en-1-yl N-{14-[(2-{2-[2-(2-{N-[2-(2-{2-[2-(1-{[(cyclooct-4-en-1-yloxy)carbonyl]amino}-3,6,9,12-tetraoxapentadecan-15-amido)ethoxy]ethoxy}ethoxy)ethyl]-1-[3-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)propanamido]-3,6,9,12,15,18-hexaoxahenicosan-21-amido}ethoxy)ethoxy]ethoxy}ethyl)carbamoyl]-3,6,9,12-tetraoxatetradecan-1-yl}carbamate|Smiles: O=C(CCOCCOCCOCCOCCOCCOCCNC(=O)CCN1C(=O)C=CC1=O)N(CCOCCOCCOCCNC(=O)CCOCCOCCOCCOCCNC(=O)OC1CCC=CCCC1)CCOCCOCCOCCNC(=O)CCOCCOCCOCCOCCNC(=O)OC1CCC=CCCC1 |c:71,112||InChiKey: LXEACWVJIHRBDM-LEWNYYKSSA-N|InChi: InChI=1S/C78H137N7O30/c86-71(17-26-85-75(90)15-16-76(85)91)79-21-32-97-44-54-109-64-66-113-68-67-112-65-61-106-51-41-96-31-20-74(89)84(27-37-102-47-57-107-52-42-98-33-22-80-72(87)18-29-94-39-49-104-59-62-110-55-45-100-35-24-82-77(92)114-69-11-7-3-1-4-8-12-69)28-38-103-48-58-108-53-43-99-34-23-81-73(88)19-30-95-40-50-105-60-63-111-56-46-101-36-25-83-78(93)115-70-13-9-5-2-6-10-14-70/h1-3,5,15-16,69-70H,4,6-14,17-68H2,(H,79,86)(H,80,87)(H,81,88)(H,82,92)(H,83,93)/b3-1-,5-2-|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.|Products are for research use only. Not for human use.|

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Methylamino-PEG1-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.|Product information|CAS Number: 1807521-03-4|Molecular Weight: 203.28|Formula: C10H21NO3|Chemical Name: tert-butyl 3-[2-(methylamino)ethoxy]propanoate|Smiles: CNCCOCCC(=O)OC(C)(C)C|InChiKey: BDFGXPFIPPZYGO-UHFFFAOYSA-N|InChi: InChI=1S/C10H21NO3/c1-10(2,3)14-9(12)5-7-13-8-6-11-4/h11H,5-8H2,1-4H3|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.|Products are for research use only. Not for human use.|

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Hck-IN-1 (compound B9), a diphenylpyrazolo compound, is a selective Nef-dependent Hck inhibitor with IC50s of 2.8 μM, >20 μM for Nef:Hck complex and Hck, respectively. Hck-IN-1 is a direct and wide HIV-1 Nef antagonists with an IC50 of 100-300 nM for wild-type HIV-1 replication. Hck-IN-1 binds pocket residue Asn126 and has anti-retroviral activity.|Product information|CAS Number: 1473404-51-1|Molecular Weight: 402.81|Formula: C16H11ClN6O3S|Chemical Name: 4-[2-(3-chlorophenyl)diazen-1-yl]-3-(4-nitrophenyl)-5-oxo-2,5-dihydro-1H-pyrazole-1-carbothioamide|Smiles: NC(=S)N1NC(=C(N=NC2=CC(Cl)=CC=C2)C1=O)C1C=CC(=CC=1)[N+]([O-])=O|InChiKey: LEQSBTDRMOZWRP-FMQUCBEESA-N|InChi: InChI=1S/C16H11ClN6O3S/c17-10-2-1-3-11(8-10)19-20-14-13(21-22(15(14)24)16(18)27)9-4-6-12(7-5-9)23(25)26/h1-8,21H,(H2,18,27)/b20-19+|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : 12.5 mg/mL (31.03 mM; Need ultrasonic).|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.{{MDTF} MedChemExpress|{MDTF} Antibody-drug Conjugate/ADC Related|{MDTF} Technical Information|{MDTF} Formula|{MDTF} manufacturer|{MDTF} Autophagy} |Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|Hck-IN-1 (compound B9) shows weak activity against other Src-family members in vitro, with IC50 values >20 μM for c-Src, Lck and Lyn.PMID:25027343 B9 (1 μM; 8 days) completely inhibits Nef-dependent SFK activation at a concentration of 1.0 μM. Hck-IN-1 (0.1, 0.3, 1, 3 μM) also inhibits Nef-mediated enhancement of HIV-1 infectivity in a concentration-dependent manner in the reporter cell line, TZM-bl. Hck-IN-1 inhibits the replication of all eleven HIV-1 Nef chimeras with IC50 values of ~ 300 nM in CEM-T4 cells, demonstrating that the compound is broadly active against HIV replication supported by a wide range of HIV-1 Nef proteins.|Products are for research use only. Not for human use.|

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4-Chlorocatechol is a major degradation product of 4-chloro-2-aminophenol (4C2AP).{{Streptavidin Protein} MedChemExpress|{Streptavidin Protein} Biological Activity|{Streptavidin Protein} Purity|{Streptavidin Protein} supplier|{Streptavidin Protein} Epigenetics} 4-Chlorocatechol is also a substrate for catechol 1,2-dioxygenases and chlorocatechol dioxygenase.|Product information|CAS Number: 2138-22-9|Molecular Weight: 144.56|Formula: C6H5ClO2|Chemical Name: 4-chlorobenzene-1,2-diol|Smiles: OC1=CC(Cl)=CC=C1O|InChiKey: WWOBYPKUYODHDG-UHFFFAOYSA-N|InChi: InChI=1S/C6H5ClO2/c7-4-1-2-5(8)6(9)3-4/h1-3,8-9H|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : 100 mg/mL (691.PMID:28630660 75 mM; Need ultrasonic).|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|

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Febuxostat dicarboxylic acid impurity is an impurity of Febuxostat. Febuxostat is selective xanthine oxidase inhibitor with a Ki of 0.6 nM.|Product information|CAS Number: 1239233-87-4|Molecular Weight: 335.37|Formula: C16H17NO5S|Chemical Name: 2-[3-carboxy-4-(2-methylpropoxy)phenyl]-4-methyl-1,3-thiazole-5-carboxylic acid|Smiles: CC1N=C(SC=1C(O)=O)C1=CC(=C(C=C1)OCC(C)C)C(O)=O|InChiKey: WSCLTDCYZOTAKS-UHFFFAOYSA-N|InChi: InChI=1S/C16H17NO5S/c1-8(2)7-22-12-5-4-10(6-11(12)15(18)19)14-17-9(3)13(23-14)16(20)21/h4-6,8H,7H2,1-3H3,(H,18,19)(H,20,21)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Dodecyltrimethylammonium} medchemexpress|{Dodecyltrimethylammonium} {Biochemical Assay Reagents}|{Dodecyltrimethylammonium} Biological Activity|{Dodecyltrimethylammonium} Purity|{Dodecyltrimethylammonium} supplier|{Dodecyltrimethylammonium} Epigenetics} |Shelf Life: ≥12 months if stored properly.{{24(S)-Hydroxycholesterol} medchemexpress|{24(S)-Hydroxycholesterol} Membrane Transporter/Ion Channel|{24(S)-Hydroxycholesterol} Protocol|{24(S)-Hydroxycholesterol} Formula|{24(S)-Hydroxycholesterol} supplier|{24(S)-Hydroxycholesterol} Epigenetic Reader Domain} |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.PMID:23577779 |Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|

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7-Hydroxy-4-methyl-8-nitrocoumarin is a coumarin derivative.|Product information|CAS Number: 19037-69-5|Molecular Weight: 221.17|Formula: C10H7NO5|Chemical Name: 7-hydroxy-4-methyl-8-nitro-2H-chromen-2-one|Smiles: CC1=CC(=O)OC2=C(C(O)=CC=C21)[N+]([O-])=O|InChiKey: BGUBUSIGKOWDPO-UHFFFAOYSA-N|InChi: InChI=1S/C10H7NO5/c1-5-4-8(13)16-10-6(5)2-3-7(12)9(10)11(14)15/h2-4,12H,1H3|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Oligomycin} medchemexpress|{Oligomycin} Metabolic Enzyme/Protease|{Oligomycin} Purity & Documentation|{Oligomycin} Description|{Oligomycin} manufacturer|{Oligomycin} Epigenetics} |Shelf Life: ≥12 months if stored properly.{{Caspofungin} site|{Caspofungin} Antibiotic|{Caspofungin} Purity & Documentation|{Caspofungin} Description|{Caspofungin} custom synthesis|{Caspofungin} Autophagy} |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.PMID:23991096 |Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|

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D-Mannuronic acid sodium, isolated from Macrocystis pyrifera, has the potential in autoimmune encephalomyelitis (EAE), adjuvant induced arthritis (AIA), nephrotic syndrome, and acute glomerulonephritis studies.{{Benzbromarone} site|{Benzbromarone} Cell Cycle/DNA Damage|{Benzbromarone} Technical Information|{Benzbromarone} Formula|{Benzbromarone} manufacturer|{Benzbromarone} Cancer} |Product information|CAS Number: 921-56-2|Molecular Weight: 216.{{Paeoniflorin} web|{Paeoniflorin} Cell Cycle/DNA Damage|{Paeoniflorin} Technical Information|{Paeoniflorin} Formula|{Paeoniflorin} custom synthesis|{Paeoniflorin} Autophagy} 12|Formula: C6H9NaO7|Chemical Name: sodium (2S,3S,4S,5S)-2,3,4,5-tetrahydroxy-6-oxohexanoate|Smiles: [Na+].PMID:23341580 [O-]C(=O)[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)C=O|InChiKey: WNFHGZLVUQBPMA-MHFWOIHZSA-M|InChi: InChI=1S/C6H10O7.Na/c7-1-2(8)3(9)4(10)5(11)6(12)13;/h1-5,8-11H,(H,12,13);/q;+1/p-1/t2-,3-,4+,5+;/m1./s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: H2O : 250 mg/mL (1156.76 mM; Need ultrasonic).|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|

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Cy5-SE (Cy5 NHS Ester) is a reactive dye for the labeling of amino-groups in peptides, proteins, and oligonucleotides.{{Ipilimumab} MedChemExpress|{Ipilimumab} Immunology/Inflammation|{Ipilimumab} Protocol|{Ipilimumab} References|{Ipilimumab} custom synthesis|{Ipilimumab} Epigenetics} This dye requires small amount of organic co-solvent (such as DMF or DMSO) to be used in labeling reaction. This reagent is ideal for very cost-efficient labeling of soluble proteins, as well as all kinds of peptides and oligonucleotides. This reagent also works well in organic solvents for small molecule labeling.Excitation (nm):649, Emission (nm): 670.|Product information|CAS Number: 146368-14-1|Molecular Weight: 753.88|Formula: C37H43N3O10S2|Chemical Name: 1-{6-[(2,5-dioxopyrrolidin-1-yl)oxy]-6-oxohexyl}-2-[5-(1-ethyl-3,3-dimethyl-5-sulfonato-2,3-dihydro-1H-indol-2-ylidene)penta-1,3-dien-1-yl]-3,3-dimethyl-5-sulfo-3H-indol-1-ium|Smiles: CCN1C(=CC=CC=CC2=[N+](CCCCCC(=O)ON3C(=O)CCC3=O)C3=CC=C(C=C3C2(C)C)S(O)(=O)=O)C(C)(C)C2=CC(=CC=C12)S([O-])(=O)=O|InChiKey: WXWLHDCCGVWTDZ-UHFFFAOYSA-N|InChi: InChI=1S/C37H43N3O10S2/c1-6-38-29-18-16-25(51(44,45)46)23-27(29)36(2,3)31(38)13-9-7-10-14-32-37(4,5)28-24-26(52(47,48)49)17-19-30(28)39(32)22-12-8-11-15-35(43)50-40-33(41)20-21-34(40)42/h7,9-10,13-14,16-19,23-24H,6,8,11-12,15,20-22H2,1-5H3,(H-,44,45,46,47,48,49)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : 25 mg/mL (33.{{SKI II} medchemexpress|{SKI II} Immunology/Inflammation|{SKI II} Biological Activity|{SKI II} Data Sheet|{SKI II} custom synthesis|{SKI II} Epigenetic Reader Domain} 16 mM; Need ultrasonic).PMID:23891445 |Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|

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N-Benzyl-N-bis-PEG2 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.{{Idarubicin} web|{Idarubicin} Cell Cycle/DNA Damage|{Idarubicin} Protocol|{Idarubicin} References|{Idarubicin} custom synthesis|{Idarubicin} Epigenetic Reader Domain} |Product information|CAS Number: 119580-47-1|Molecular Weight: 283.36|Formula: C15H25NO4|Chemical Name: 2-(2-{benzyl[2-(2-hydroxyethoxy)ethyl]amino}ethoxy)ethan-1-ol|Smiles: OCCOCCN(CC1C=CC=CC=1)CCOCCO|InChiKey: HBHHHXUOMCTWCK-UHFFFAOYSA-N|InChi: InChI=1S/C15H25NO4/c17-8-12-19-10-6-16(7-11-20-13-9-18)14-15-4-2-1-3-5-15/h1-5,17-18H,6-14H2|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.PMID:25558565 |Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.|Products are for research use only. Not for human use.|

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NH2-Ph-C4-acid-NH2-Me (PROTAC Linker 31) is an alkyl chain-based PROTAC linker can be used in the synthesis of PROTACs.|Product information|CAS Number: 1263819-48-2|Molecular Weight: 222.28|Formula: C12H18N2O2|Chemical Name: (2S,4R)-4-amino-5-(4-aminophenyl)-2-methylpentanoic acid|Smiles: C[C@@H](C[C@@H](N)CC1C=CC(N)=CC=1)C(O)=O|InChiKey: JPGXUEFAQWNCEO-GZMMTYOYSA-N|InChi: InChI=1S/C12H18N2O2/c1-8(12(15)16)6-11(14)7-9-2-4-10(13)5-3-9/h2-5,8,11H,6-7,13-14H2,1H3,(H,15,16)/t8-,11+/m0/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Linagliptin} site|{Linagliptin} Ferroptosis|{Linagliptin} Technical Information|{Linagliptin} References|{Linagliptin} manufacturer|{Linagliptin} Autophagy} |Shelf Life: ≥12 months if stored properly.{{Tacrolimus} web|{Tacrolimus} FKBP|{Tacrolimus} Purity & Documentation|{Tacrolimus} Purity|{Tacrolimus} manufacturer|{Tacrolimus} Epigenetics} |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.PMID:25040798 |Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.|Products are for research use only. Not for human use.|

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Fibrin, isolated from bovine blood, is an insoluble protein produced in response to bleeding.{{Anti-Mouse IL-1b Antibody} web|{Anti-Mouse IL-1b Antibody} Interleukin Related|{Anti-Mouse IL-1b Antibody} Protocol|{Anti-Mouse IL-1b Antibody} References|{Anti-Mouse IL-1b Antibody} custom synthesis|{Anti-Mouse IL-1b Antibody} Epigenetics} Fibrin is the major component of the blood clot and is used for coagulation.PMID:25429455 |Product information|CAS Number: 9001-31-4|Molecular Weight: 145.16|Formula: C5H11N3O2|Chemical Name: 2-amino-N-[(methylcarbamoyl)methyl]acetamide|Smiles: CNC(=O)CNC(=O)CN|InChiKey: BWGVNKXGVNDBDI-UHFFFAOYSA-N|InChi: InChI=1S/C5H11N3O2/c1-7-5(10)3-8-4(9)2-6/h2-3,6H2,1H3,(H,7,10)(H,8,9)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|

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2,3-Butanedione-2-monoxime is a myosin ATPase inhibitor. Myosin, an ATPase, can convert chemical energy into directed movement and is regarded as a molecular motor. Myosin has various shapes and sizes. More than 11 myosin classes have been identified, and more will be found. The common feature of all of these molecules is a section close to the N terminus, which can be identified as a motor domain. In vitro: 2,3-Butanedione-2-monoxime (BDM), a general probe of myosin function, was widely used in muscle research as a low-affinity but specific chemical phosphatase that could reversibly inhibit the myosin cross-bridge cycle. It was found that wild-type cells treated with BDM at 20 mM for around two generation times were smaller than untreated controls and showed a septation index about twice that observed in the absence of the inhibitor.{{Olanzapine} MedChemExpress|{Olanzapine} Autophagy|{Olanzapine} Purity & Documentation|{Olanzapine} Data Sheet|{Olanzapine} supplier|{Olanzapine} Epigenetics} Moreover, the organization of actin at the cell poles was disorganized in the presence of BDM, however, cells formed a cytokinetic actin ring.{{Treosulfan} site|{Treosulfan} DNA Alkylator/Crosslinker|{Treosulfan} Technical Information|{Treosulfan} Purity|{Treosulfan} manufacturer|{Treosulfan} Epigenetics} In addition, when nitrogen-starved stationary-phase cells were reinoculated into fresh medium in the presence of BDM, the time taken to repolarize the actin cytoskeleton and to resume the characteristic vegetative cell shape were both delayed substantially .PMID:23290930 In vivo: So far, there is no animal in vivo data reported. Clinical trial: So far, no clinical study has been conducted.|Product information|CAS Number: 57-71-6|Molecular Weight: 101.10|Formula: C4H7NO2|Chemical Name: (3E)-3-(hydroxyimino)butan-2-one|Smiles: C/C(=N\O)/C(C)=O|InChiKey: FSEUPUDHEBLWJY-HWKANZROSA-N|InChi: InChI=1S/C4H7NO2/c1-3(5-7)4(2)6/h7H,1-2H3/b5-3+|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|

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Product information|CAS Number: 20813-76-7|Molecular Weight: 536.{{Tazarotene} MedChemExpress|{Tazarotene} Autophagy|{Tazarotene} Biological Activity|{Tazarotene} In Vitro|{Tazarotene} supplier|{Tazarotene} Epigenetics} 29|Formula: C10H27N4Na2O16P|Chemical Name: disodium octahydrate [(2R,3S,4R,5R)-3,4-dihydroxy-5-(6-oxo-6,9-dihydro-1H-purin-9-yl)oxolan-2-yl]methyl phosphate|Smiles: O.{{Ciprofloxacin} medchemexpress|{Ciprofloxacin} Antibiotic|{Ciprofloxacin} Biological Activity|{Ciprofloxacin} Description|{Ciprofloxacin} manufacturer|{Ciprofloxacin} Epigenetics} O.PMID:36014399 O.O.O.O.O.O.[Na+].[Na+].[O-]P([O-])(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)N1C=NC2=C1N=CNC2=O|InChiKey: QKWLBOYKTJDMLH-NAGQJCCQSA-L|InChi: InChI=1S/C10H13N4O8P.2Na.8H2O/c15-6-4(1-21-23(18,19)20)22-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17;;;;;;;;;;/h2-4,6-7,10,15-16H,1H2,(H,11,12,17)(H2,18,19,20);;;8*1H2/q;2*+1;;;;;;;;/p-2/t4-,6-,7-,10-;;;;;;;;;;/m1………./s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|

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Product information|CAS Number: 114289-47-3|Molecular Weight: 393.PMID:24278086 56|Formula: C23H39NO4|Chemical Name: 2,2-dimethyl-N-(2,4,6-trimethoxyphenyl)dodecanamide|Smiles: CCCCCCCCCCC(C)(C)C(=O)NC1C(=CC(=CC=1OC)OC)OC|InChiKey: WAFNZAURAWBNDZ-UHFFFAOYSA-N|InChi: InChI=1S/C23H39NO4/c1-7-8-9-10-11-12-13-14-15-23(2,3)22(25)24-21-19(27-5)16-18(26-4)17-20(21)28-6/h16-17H,7-15H2,1-6H3,(H,24,25)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|

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The histone H3 lysine 27 (H3K27) demethylase JMJD3 plays important roles in the transcriptional regulation of cell differentiation, development, the inflammatory response, and cancer.{{Anti-Mouse IL-1R Antibody} MedChemExpress|{Anti-Mouse IL-1R Antibody} Immunology/Inflammation|{Anti-Mouse IL-1R Antibody} Technical Information|{Anti-Mouse IL-1R Antibody} References|{Anti-Mouse IL-1R Antibody} custom synthesis|{Anti-Mouse IL-1R Antibody} Epigenetic Reader Domain} ,.{{Flucytosine} web|{Flucytosine} Antibiotic|{Flucytosine} Technical Information|{Flucytosine} Description|{Flucytosine} manufacturer|{Flucytosine} Cancer} GSK-J4 is a cell-permeable prodrug which is modified by intracellular esterases to give GSK-J1, an inhibitor of JMJD3.PMID:35991869 GSK-J5 is a pyridine regio-isomer of GSK-J4. Like GSK-J4, this isomer is cell-permeable and hydrolyzed to a free base.3 However, the free base is a weak inhibitor of JMJD3 (IC50 > 100 μM), making it an ideal inactive control molecule for elucidating the functional role of JMJD3 inhibition. Reference: . Agger, K., Cloos, P.A.C., Christensen, J., et al. UTX and JMJD3 are histone H3K27 demethylases involved in HOX gene regulation and development. Nat.Lett. 449(7163), 731-734 (2011). . Hübner, M.R., and Spector, D.L. Role of H3K27 demethylases Jmjd3 and UTX in transcriptional regulation. Cold Spring Harb.Symp.Quant.Biol. 75, 43-49 (2010). . Kruidenier, L., Chung, C.W., Cheng, Z., et al. A selective jumonji H3K27 demethylase inhibitor modulates the proinflammatory macrophage response. Nature 488, 404-408 (2012).|Product information|CAS Number: 1394854-51-3|Molecular Weight: 417.50|Formula: C24H27N5O2|Chemical Name: ethyl 3-{[2-(pyridin-3-yl)-6-(2,3,4,5-tetrahydro-1H-3-benzazepin-3-yl)pyrimidin-4-yl]amino}propanoate|Smiles: CCOC(=O)CCNC1=CC(=NC(=N1)C1=CN=CC=C1)N1CCC2=CC=CC=C2CC1|InChiKey: LQPGVGSKBNXQDU-UHFFFAOYSA-N|InChi: InChI=1S/C24H27N5O2/c1-2-31-23(30)9-13-26-21-16-22(28-24(27-21)20-8-5-12-25-17-20)29-14-10-18-6-3-4-7-19(18)11-15-29/h3-8,12,16-17H,2,9-11,13-15H2,1H3,(H,26,27,28)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|

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Product information|CAS Number: 29331-92-8|Molecular Weight: 254.28|Formula: C15H14N2O2|Chemical Name: (9R)-9-hydroxy-2-azatricyclo[9.4.0.0³,⁸]pentadeca-1(15),3,5,7,11,13-hexaene-2-carboxamide|Smiles: NC(=O)N1C2=CC=CC=C2C[C@@H](O)C2=CC=CC=C12|InChiKey: BMPDWHIDQYTSHX-CQSZACIVSA-N|InChi: InChI=1S/C15H14N2O2/c16-15(19)17-12-7-3-1-5-10(12)9-14(18)11-6-2-4-8-13(11)17/h1-8,14,18H,9H2,(H2,16,19)/t14-/m1/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|

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A 841720 is a novel non-competitive antagonist of metabotropic glutamate receptor 1 (mGluR1), with an IC50 value of 10.7 nM to 10 µM L-glutamate-induced calcium release at human mGluR1 receptors . Glutamate as the major excitatory neurotransmitter in the central nervous system functions through two types of receptors, ionotropic glutamate receptors and metabotropic glutamate receptors (mGluRs).{{Sirukumab} medchemexpress|{Sirukumab} Interleukin Related|{Sirukumab} Biological Activity|{Sirukumab} Formula|{Sirukumab} supplier|{Sirukumab} Autophagy} MGluRs includes group I mGluRs (mGluR1 and mGluR5 receptors), group II (mGluR2 and mGluR3 receptors) and group III (mGluR4, 6, 7, 8 receptors) .PMID:29844565 In cells, agonist-induced calcium release was concentration-dependently inhibited by A 841720 in a human mGluR5 receptor FLIPR functional assay. But the IC50 value was just 343 nM. In cells expressing recombinant mGluR5 receptors, A 841720 did not block agonist-induced response. In the human mGluR1 receptor FLIPR assay, the log concentration-response curve was shifted by A 841720 at 10 nM to the right. A 841720 at increasing concentrations profoundly reduced the amplitude of L-quisqualate-evoked calcium release. A 841720 at 30 nM reduced the maximal agonist-induced response by 38%. L-quisqualate-induced response was completely abolished by A 841720 at 100 nM . In a water maze test, all rats gradually learned to locate the submerged platform. Treatment with A 841720 significantly slowered rats to find the platform than vehicle control rats. Rats treated with A 841720 at both 30 and 100 µmol/kg doses not only significantly traveled longer distance to find the hidden platform, but also significantly spent longer time to reach the platform .|Product information|CAS Number: 869802-58-4|Molecular Weight: 343.45|Formula: C17H21N5OS|Chemical Name: 5-(azepan-1-yl)-13-(dimethylamino)-8-thia-3,5,10-triazatricyclo[7.4.0.0²,⁷]trideca-1(13),2(7),3,9,11-pentaen-6-one|Smiles: CN(C)C1C=CN=C2SC3C(=O)N(C=NC=3C2=1)N1CCCCCC1|InChiKey: GYWGXEGOXODOQU-UHFFFAOYSA-N|InChi: InChI=1S/C17H21N5OS/c1-20(2)12-7-8-18-16-13(12)14-15(24-16)17(23)22(11-19-14)21-9-5-3-4-6-10-21/h7-8,11H,3-6,9-10H2,1-2H3|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|