Proton-pump inhibitor proton-pump.com

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GS-9901 is a highly selective and orally active PI3Kδ inhibitor, with an IC50 of 1 nM. Has potential to treat rheumatoid arthritis.|Product information|CAS Number: 1640247-87-5|Molecular Weight: 477.88|Formula: C22H17ClFN9O|Chemical Name: 2,4-diamino-6-{[(S)-[5-chloro-8-fluoro-4-oxo-3-(pyridin-3-yl)-3,4-dihydroquinazolin-2-yl](cyclopropyl)methyl]amino}pyrimidine-5-carbonitrile|Smiles: NC1=NC(N)=C(C#N)C(N[C@@H](C2CC2)C2=NC3=C(F)C=CC(Cl)=C3C(=O)N2C2=CN=CC=C2)=N1|InChiKey: XDSXYMOZKDUASY-INIZCTEOSA-N|InChi: InChI=1S/C22H17ClFN9O/c23-13-5-6-14(24)17-15(13)21(34)33(11-2-1-7-28-9-11)20(30-17)16(10-3-4-10)29-19-12(8-25)18(26)31-22(27)32-19/h1-2,5-7,9-10,16H,3-4H2,(H5,26,27,29,31,32)/t16-/m0/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vivo:|GS-9901 (0.3/1/3 mg/kg, orally, twice daily for 7 days) demonstrates efficacy in a rat model of arthritis and is predicted to be suitable for q.d. dosing in humans.|Products are for research use only. Not for human use.|

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Tiotropium bromide is a long-acting, 24-hour, anticholinergic bronchodilator used in the management of chronic obstructive pulmonary disease (COPD).{{Canagliflozin} MedChemExpress|{Canagliflozin} SGLT|{Canagliflozin} Purity & Documentation|{Canagliflozin} Description|{Canagliflozin} custom synthesis|{Canagliflozin} Autophagy} Tiotropium is a muscarinic receptor antagonist, often referred to as an antimuscarinic or anticholinergic agent.{{Grazoprevir} site|{Grazoprevir} Anti-infection|{Grazoprevir} Purity & Documentation|{Grazoprevir} Data Sheet|{Grazoprevir} supplier|{Grazoprevir} Autophagy} Although it does not display selectivity for specific muscarinic receptors, when topically applied it acts mainly on M3 muscarinic receptors[7] located on smooth muscle cells and submucosal glands.PMID:24631563 This leads to a reduction in smooth muscle contraction and mucus secretion and thus produces a bronchodilatory effect.|Product information|CAS Number: 136310-93-5|Molecular Weight: 472.42|Formula: C19H22BrNO4S2|Chemical Name: (1R,2R,4S,5S)-7-{[2-hydroxy-2,2-bis(thiophen-2-yl)acetyl]oxy}-9,9-dimethyl-3-oxa-9-azatricyclo[3.3.1.0²,⁴]nonan-9-ium bromide|Smiles: [Br-].C[N+]1(C)[C@@H]2CC(C[C@H]1[C@@H]1O[C@H]21)OC(=O)C(O)(C1=CC=CS1)C1=CC=CS1|InChiKey: DQHNAVOVODVIMG-RGECMCKFSA-M|InChi: InChI=1S/C19H22NO4S2.BrH/c1-20(2)12-9-11(10-13(20)17-16(12)24-17)23-18(21)19(22,14-5-3-7-25-14)15-6-4-8-26-15;/h3-8,11-13,16-17,22H,9-10H2,1-2H3;1H/q+1;/p-1/t11?,12-,13+,16-,17+;|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥360 days if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|

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MK8033 is a selective small-molecule inhibitor, ATP competitive. Phase I investigation of the cMet inhibitor MK-8033 is ongoing. Plans include a trial of this agent in refractory colorectal cancer, with pre- and post-treatment biopsies to evaluate for relevant molecular signatures.|Product information|CAS Number: 1001917-37-8|Molecular Weight: 471.PMID:29844565 53|Formula: C25H21N5O3S|Synonym:|MK-8033|MK 8033|MK8033|Chemical Name: 1-[5-(1-methyl-1H-pyrazol-4-yl)-2-oxo-7-azatricyclo[9.4.0.0³,⁸]pentadeca-1(11),3(8),4,6,9,12,14-heptaen-14-yl]-N-[(pyridin-2-yl)methyl]methanesulfonamide|Smiles: CN1C=C(C=N1)C1=CC2=C(C=CC3=CC=C(CS(=O)(=O)NCC4=CC=CC=N4)C=C3C2=O)N=C1|InChiKey: VMJFTOSOFDEKTM-UHFFFAOYSA-N|InChi: InChI=1S/C25H21N5O3S/c1-30-15-20(13-28-30)19-11-23-24(27-12-19)8-7-18-6-5-17(10-22(18)25(23)31)16-34(32,33)29-14-21-4-2-3-9-26-21/h2-13,15,29H,14,16H2,1H3|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥360 days if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|

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3-O-Methyldopa (3-Methoxy-L-tyrosine) is a metabolite of L-DOPA which is formed by catechol-O-methyltransferase (COMT). 3-O-Methyldopa competitively inhibits the pharmacodynamics of l-DOPA and dopamine.|Product information|CAS Number: 300-48-1|Molecular Weight: 211.21|Formula: C10H13NO4|Chemical Name: (2S)-2-amino-3-(4-hydroxy-3-methoxyphenyl)propanoic acid|Smiles: COC1=CC(C[C@H](N)C(O)=O)=CC=C1O|InChiKey: PFDUUKDQEHURQC-ZETCQYMHSA-N|InChi: InChI=1S/C10H13NO4/c1-15-9-5-6(2-3-8(9)12)4-7(11)10(13)14/h2-3,5,7,12H,4,11H2,1H3,(H,13,14)/t7-/m0/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: H2O : 16.{{Ulixertinib} web|{Ulixertinib} Stem Cell/Wnt|{Ulixertinib} Technical Information|{Ulixertinib} References|{Ulixertinib} supplier|{Ulixertinib} Autophagy} 67 mg/mL (78.{{Zandelisib} medchemexpress|{Zandelisib} PI3K/Akt/mTOR|{Zandelisib} Protocol|{Zandelisib} Data Sheet|{Zandelisib} manufacturer|{Zandelisib} Epigenetic Reader Domain} 93 mM; Need ultrasonic).PMID:34645436 |Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|

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BIO5192 is a selective and potent integrin α4β1 (VLA-4) inhibitor (KdProduct information|CAS Number: 327613-57-0|Molecular Weight: 817.78|Formula: C38H46Cl2N6O8S|Chemical Name: (2S)-2-{[(2S)-1-(3,5-dichlorobenzenesulfonyl)pyrrolidin-2-yl]formamido}-4-[(2S)-4-methyl-2-[N-methyl-2-(4-{[(2-methylphenyl)carbamoyl]amino}phenyl)acetamido]pentanamido]butanoic acid|Smiles: CN([C@@H](CC(C)C)C(=O)NCC[C@H](NC(=O)[C@@H]1CCCN1S(=O)(=O)C1C=C(Cl)C=C(Cl)C=1)C(O)=O)C(=O)CC1C=CC(=CC=1)NC(=O)NC1=CC=CC=C1C|InChiKey: MNQBPRHHZPXCKZ-ZDCRTTOTSA-N|InChi: InChI=1S/C38H46Cl2N6O8S/c1-23(2)18-33(45(4)34(47)19-25-11-13-28(14-12-25)42-38(52)44-30-9-6-5-8-24(30)3)35(48)41-16-15-31(37(50)51)43-36(49)32-10-7-17-46(32)55(53,54)29-21-26(39)20-27(40)22-29/h5-6,8-9,11-14,20-23,31-33H,7,10,15-19H2,1-4H3,(H,41,48)(H,43,49)(H,50,51)(H2,42,44,52)/t31-,32-,33-/m0/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.PMID:23613863 |Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vivo:|The combination of BIO5192 (1 mg/kg; i.v.) and Plerixafor (5 mg/kg; s.c.) exert an additive effect on progenitor mobilization. BIO5192 (30 mg/kg; s.c; bid; during days 5 through 14) delays paralysis associated with EAE (experimental autoimmune encephalomyelitis). BIO5192 (1 mg/kg, i.v.) shows the terminal half-life is 1.1 hours. BIO5192 (3, 10, and 30 mg/kg; s.c.) shows half-lives of 1.7, 2.7, and 4.7 hours, respectively. The blood plasma curves show that the AUC for the s.c. route of administration increased about 2.5-fold from 5,460 h*ng/ml for the 3 mg/kg dose to 14,175 h*ng/ml for the 30 mg/kg.|Products are for research use only. Not for human use.|

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Escitalopram is an antidepressant of the selective serotonin reuptake inhibitor (SSRI) class.|Product information|CAS Number: 128196-01-0|Molecular Weight: 324.39|Formula: C20H21FN2O|Chemical Name: (1S)-1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile|Smiles: CN(C)CCC[C@]1(OCC2=CC(=CC=C12)C#N)C1C=CC(F)=CC=1|InChiKey: WSEQXVZVJXJVFP-FQEVSTJZSA-N|InChi: InChI=1S/C20H21FN2O/c1-23(2)11-3-10-20(17-5-7-18(21)8-6-17)19-9-4-15(13-22)12-16(19)14-24-20/h4-9,12H,3,10-11,14H2,1-2H3/t20-/m0/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥360 days if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|

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AM-2394 is a structurally distinct glucokinase activator (GKA). AM-2394 activates glucokinase (GK) with an EC50 of 60 nM.|Product information|CAS Number: 1442684-77-6|Molecular Weight: 423.47|Formula: C22H25N5O4|Chemical Name: 1-[6′-(2-hydroxy-2-methylpropoxy)-4-[(5-methylpyridin-3-yl)oxy]-[3,3′-bipyridin]-6-yl]-3-methylurea|Smiles: CC1C=C(C=NC=1)OC1C=C(NC(=O)NC)N=CC=1C1C=NC(=CC=1)OCC(C)(C)O|InChiKey: QUISANLDBDCMPD-UHFFFAOYSA-N|InChi: InChI=1S/C22H25N5O4/c1-14-7-16(11-24-9-14)31-18-8-19(27-21(28)23-4)25-12-17(18)15-5-6-20(26-10-15)30-13-22(2,3)29/h5-12,29H,13H2,1-4H3,(H2,23,25,27,28)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : ≥ 30 mg/mL (70.84 mM).|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.PMID:28739548 |Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vivo:|AM-2394, a structurally distinct glucokinase activator that displays a robust reduction in plasma glucose during an oral glucose tolerance test (OGTT) in ob/ob mice at a dose of 3 mg/kg. AM-2394 increases the affinity of glucokinase (GK) for glucose by approximately 10-fold, exhibits moderate clearance and good oral bioavailability in multiple animal models, and lowers glucose excursion following an oral glucose tolerance test in an ob/ob mouse model of diabetes. AM-2394 exhibits good-to-moderate cross species plasma clearance, volume of distribution, and oral bioavailability, allowing for further evaluation in animal models.|Products are for research use only. Not for human use.|

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Myristicin (Myristicine), a terpene-like active component in Nutmeg which is the seed of Myristica fragrans, is a weak inhibitor of monamine oxidase (MAO) and a mechanism-based inhibitor of CYP1A2.|Product information|CAS Number: 607-91-0|Molecular Weight: 192.21|Formula: C11H12O3|Chemical Name: 4-methoxy-6-(prop-2-en-1-yl)-2H-1, 3-benzodioxole|Smiles: COC1=CC(CC=C)=CC2OCOC1=2|InChiKey: BNWJOHGLIBDBOB-UHFFFAOYSA-N|InChi: InChI=1S/C11H12O3/c1-3-4-8-5-9(12-2)11-10(6-8)13-7-14-11/h3,5-6H,1,4,7H2,2H3|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: Solubility (25°C).|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|

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Trypan Blue (Visionblue, Diphenyl Blue, Direct Blue 14) is a colorimetric dye that stains dead cells with a blue color easily observed using light microscopy at low resolution.|Product information|CAS Number: 72-57-1|Molecular Weight: 960.81|Formula: C34H24N6Na4O14S4|Chemical Name: tetrasodium;5-amino-3-[[4-[4-[(8-amino-1-hydroxy-3, 6-disulfonatonaphthalen-2-yl)diazenyl]-3-methylphenyl]-2-methylphenyl]diazenyl]-4-hydroxynaphthalene-2, 7-disulfonate|Smiles: [Na+].{{Tegoprubart} site|{Tegoprubart} Purity & Documentation|{Tegoprubart} Description|{Tegoprubart} supplier|{Tegoprubart} Epigenetic Reader Domain} [Na+].[Na+].[Na+].CC1C=C(C=CC=1N=NC1=C(C=C2C=C(C=C(N)C2=C1O)S([O-])(=O)=O)S([O-])(=O)=O)C1C=C(C)C(=CC=1)N=NC1=C(C=C2C=C(C=C(N)C2=C1O)S([O-])(=O)=O)S([O-])(=O)=O|InChiKey: GLNADSQYFUSGOU-GPTZEZBUSA-J|InChi: InChI=1S/C34H28N6O14S4.PMID:23618405 4Na/c1-15-7-17(3-5-25(15)37-39-31-27(57(49,50)51)11-19-9-21(55(43,44)45)13-23(35)29(19)33(31)41)18-4-6-26(16(2)8-18)38-40-32-28(58(52,53)54)12-20-10-22(56(46,47)48)14-24(36)30(20)34(32)42;;;;/h3-14,41-42H,35-36H2,1-2H3,(H,43,44,45)(H,46,47,48)(H,49,50,51)(H,52,53,54);;;;/q;4*+1/p-4/b39-37+,40-38+;;;;|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: Solubility (25°C). 100 mg/mL(104.07 mM). 100 mg/mL(104.07 mM).|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|

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Ethyl ferulate, a naturally lipophilic derivative of ferulic acid originally derived from giant fennel (F. communis), induces heme oxygenase-1 (HO-1) and protects rat neurons against oxidative stress. Ethyl ferulate also protects neurons against amyloid β peptide (1-42)-induced oxidative stress and neurotoxicity.|Product information|CAS Number: 4046-02-0|Molecular Weight: 222.24|Formula: C12H14O4|Chemical Name: ethyl (2E)-3-(4-hydroxy-3-methoxyphenyl)prop-2-enoate|Smiles: COC1=CC(/C=C/C(=O)OCC)=CC=C1O|InChiKey: ATJVZXXHKSYELS-FNORWQNLSA-N|InChi: InChI=1S/C12H14O4/c1-3-16-12(14)7-5-9-4-6-10(13)11(8-9)15-2/h4-8,13H,3H2,1-2H3/b7-5+|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : ≥ 100 mg/mL (449.96 mM).|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|References:|Scapagnini G, et al. Ethyl ferulate, a lipophilic polyphenol, induces HO-1 and protects rat neurons against oxidative stress. Antioxid Redox Signal. 2004 Oct;6(5):811-8.Sultana R, et al. Ferulic acid ethyl ester protects neurons against amyloid beta- peptide(1-42)-induced oxidative stress and neurotoxicity: relationship to antioxidant activity. J Neurochem. 2005 Feb;92(4):749-58.Products are for research use only. Not for human use.|

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Phenethyl alcohol (2-phenylethanol, 2-Phenylethyl alcohol, Benzeneethanol, Phenylethanol) is an antimicrobial, antiseptic, and disinfectant that is used also as an aromatic essence and preservative in pharmaceutics and perfumery.|Product information|CAS Number: 60-12-8|Molecular Weight: 122.{{Quizartinib} site|{Quizartinib} Apoptosis|{Quizartinib} Purity & Documentation|{Quizartinib} In Vitro|{Quizartinib} custom synthesis|{Quizartinib} Cancer} 16|Formula: C8H10O|Synonym:|Phenylethyl alcohol|Phenethyl alcohol|Benzyl carbinol|Chemical Name: 2-phenylethan-1-ol|Smiles: OCCC1C=CC=CC=1|InChiKey: WRMNZCZEMHIOCP-UHFFFAOYSA-N|InChi: InChI=1S/C8H10O/c9-7-6-8-4-2-1-3-5-8/h1-5,9H,6-7H2|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: Solubility (25°C).{{Doxazosin} web|{Doxazosin} Autophagy|{Doxazosin} Purity & Documentation|{Doxazosin} In stock|{Doxazosin} supplier|{Doxazosin} Epigenetics} |Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.PMID:24563649 |Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|Phenethyl alcohol has been shown to interact with the cytoplasmic membrane of other microorganisms in various ways. Escherichia coli phenethyl alcohol, at a concentration higher than that used to induce myxospore formation, inhibits growth by causing a breakdown in the cellular permeabihty barrier. At lower concentrations, phospholipid synthesis, uptake of gentian violet in E. coli and the uptake of several amino acids by Neurospora crassa were all inhibited by phenethyl alcohol.|References:|Lingappa BT, et al. Phenethyl alcohol and tryptophol: autoantibiotics produced by the fungus Candida albicans. Science. 1969 Jan 10;163(3863):192-4.Products are for research use only. Not for human use.|

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Lanraplenib monosuccinate (GS-9876 monosuccinate) is a highly selective and orally active SYK inhibitor (IC50=9.5 nM) in development for the treatment of inflammatory diseases. Lanraplenib monosuccinate (GS-9876 monosuccinate) inhibits SYK activity in platelets via the glycoprotein VI (GPVI) receptor without prolonging bleeding time (BT) in monkeys or humans.|Product information|CAS Number: 1800046-97-2|Molecular Weight: 561.59|Formula: C27H31N9O5|Chemical Name: 6-[8-({4-[4-(oxetan-3-yl)piperazin-1-yl]phenyl}amino)imidazo[1,2-a]pyrazin-6-yl]pyrazin-2-amine; butanedioic acid|Smiles: NC1=CN=CC(=N1)C1=CN2C=CN=C2C(NC2C=CC(=CC=2)N2CCN(CC2)C2COC2)=N1.{{Vobramitamab} medchemexpress|{Vobramitamab} Antibody-drug Conjugate/ADC Related|{Vobramitamab} Technical Information|{Vobramitamab} Purity|{Vobramitamab} custom synthesis|{Vobramitamab} Autophagy} OC(=O)CCC(O)=O|InChiKey: DVFRSTNNWJHWGW-UHFFFAOYSA-N|InChi: InChI=1S/C23H25N9O.{{Isoniazid} web|{Isoniazid} Autophagy|{Isoniazid} Biological Activity|{Isoniazid} References|{Isoniazid} supplier|{Isoniazid} Cancer} C4H6O4/c24-21-12-25-11-19(28-21)20-13-32-6-5-26-23(32)22(29-20)27-16-1-3-17(4-2-16)30-7-9-31(10-8-30)18-14-33-15-18;5-3(6)1-2-4(7)8/h1-6,11-13,18H,7-10,14-15H2,(H2,24,28)(H,27,29);1-2H2,(H,5,6)(H,7,8)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : 125 mg/mL (222.PMID:23522542 58 mM; Need ultrasonic).|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|Lanraplenib monosuccinate (GS-9876 monosuccinate) inhibits anti-IgM stimulated phosphorylation of AKT, BLNK, BTK, ERK, MEK, and PKCδ in human B cells with EC50 values of 24-51 nM. Lanraplenib monosuccinate inhibits anti-IgM mediated CD69 and CD86 expression on B-cells (EC50=112±10 nM and 164±15 nM, respectively) and anti-IgM /anti-CD40 co-stimulated B cell proliferation (EC50=108±55 nM). In human macrophages, Lanraplenib monosuccinate inhibits IC-stimulated TNFα and IL-1β release (EC50=121±77 nM and 9±17 nM, respectively). Lanraplenib monosuccinate (GS-9876 monosuccinate) inhibits glycoprotein VI (GPVI)-induced phosphorylation of linker for activation of T cells and phospholipase Cγ2, platelet activation and aggregation in human whole blood, and platelet binding to collagen under arterial flow.|Products are for research use only. Not for human use.|

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Pifithrin-alpha is a p53 inactivator.{{Farletuzumab ecteribulin} MedChemExpress|{Farletuzumab ecteribulin} Antibody-drug Conjugate/ADC Related|{Farletuzumab ecteribulin} Technical Information|{Farletuzumab ecteribulin} References|{Farletuzumab ecteribulin} supplier|{Farletuzumab ecteribulin} Autophagy} It also has neuroprotective activity against strokes.PMID:24732841 |Product information|CAS Number: 63208-82-2|Molecular Weight: 367.30|Formula: C16H19BrN2OS|Chemical Name: 2-(2-imino-2,3,4,5,6,7-hexahydro-1,3-benzothiazol-3-yl)-1-(4-methylphenyl)ethan-1-one hydrobromide|Smiles: Br.CC1C=CC(=CC=1)C(=O)CN1C(=N)SC2CCCCC1=2|InChiKey: HAGVCKULCLQGRF-UHFFFAOYSA-N|InChi: InChI=1S/C16H18N2OS.BrH/c1-11-6-8-12(9-7-11)14(19)10-18-13-4-2-3-5-15(13)20-16(18)17;/h6-9,17H,2-5,10H2,1H3;1H|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥360 days if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|

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Monoacylglycerol lipase inhibitor 1 is a potent monoacylglycerol lipase inhibitor (compound 13).|Product information|CAS Number: 2714570-98-4|Molecular Weight: 356.46|Formula: C21H28N2O3|Smiles: CC(C)C1C=CC(=CC=1)[C@@H]1C[C@@H](C1)N(C)C(=O)[C@@H]1C[C@@]2(COC(=O)N2)C1|InChiKey: BKAUVVYBHJYFLY-BXCOXIEISA-N|InChi: InChI=1S/C21H28N2O3/c1-13(2)14-4-6-15(7-5-14)16-8-18(9-16)23(3)19(24)17-10-21(11-17)12-26-20(25)22-21/h4-7,13,16-18H,8-12H2,1-3H3,(H,22,25)/t16-,17-,18+,21+|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: To be determined|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|References:|Ram W Sabnis, et al. Novel Aminocyclobutanes as Monoacylglycerol Lipase Modulators. ACS Med Chem Lett. 2022 Feb 1;13(2):162-163.Products are for research use only. Not for human use.|

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GDC-1971 (compound 199) is a SHP2 inhibitor.|Product information|CAS Number: 2377352-49-1|Molecular Weight: 454.53|Formula: C25H26N8O|Smiles: N[C@@H]1C2=CC=CC=C2OC21CCN(CC2)C1=CN=C2C(NN=C2N2CCCC3=NC=CC=C23)=N1|InChiKey: RGCGBFIARQENML-JOCHJYFZSA-N|InChi: InChI=1S/C25H26N8O/c26-22-16-5-1-2-8-19(16)34-25(22)9-13-32(14-10-25)20-15-28-21-23(29-20)30-31-24(21)33-12-4-6-17-18(33)7-3-11-27-17/h1-3,5,7-8,11,15,22H,4,6,9-10,12-14,26H2,(H,29,30,31)/t22-/m1/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: To be determined|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|References:|Alexander M, et al. Shp2 phosphatase inhibitors and methods of use thereof. Patent WO2019183367A1.Products are for research use only. Not for human use.|

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(R, S)-CFT8634 is a selective and orally active BRD9 protein degrader. (R, S)-CFT8634 has the potential for the research of disorders mediated by BRD9, including but not limited to abnormal cellular proliferation (extracted from patent WO2021178920A1, compound 176). (R, S)-CFT8634 is a selective and orally active BRD9 protein degrader. (R, S)-CFT8634 has the potential for the research of disorders mediated by BRD9, including but not limited to abnormal cellular proliferation (extracted from patent WO2021178920A1, compound 176)[1].|Product information|CAS Number: 2704619-11-2|Molecular Weight: 710.79|Formula: C37H45F3N6O5|Smiles: CN1C=C(C2C=C(OC)C(CN3CC(F)(F)[C@@H](CC3)N3CCN(CC3)C3=CC=C(C=C3F)N[C@H]3CCC(=O)NC3=O)=C(C=2)OC)C(C)=C(C)C1=O|InChiKey: GNRGNRCQXHMQQV-RYCFQHDISA-N|InChi: InChI=1S/C37H45F3N6O5/c1-22-23(2)36(49)43(3)19-26(22)24-16-31(50-4)27(32(17-24)51-5)20-44-11-10-33(37(39,40)21-44)46-14-12-45(13-15-46)30-8-6-25(18-28(30)38)41-29-7-9-34(47)42-35(29)48/h6,8,16-19,29,33,41H,7,9-15,20-21H2,1-5H3,(H,42,47,48)/t29-,33+/m0/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: To be determined|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|

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MIPS-521 is a positive allosteric modulator of the A1R, exhibits analgesic efficacy in rats in vivo through modulation of the increased levels of endogenous adenosine that occur in the spinal cord of rats with neuropathic pain. We also report the structure of the A1R co-bound to adenosine, MIPS521 and a Gi2 heterotrimer, revealing an extrahelical lipid-detergent-facing allosteric binding pocket that involves transmembrane helixes 1, 6 and 7. Molecular dynamics simulations and ligand kinetic binding experiments support a mechanism whereby MIPS521 stabilizes the adenosine-receptor-G protein complex.|Product information|CAS Number: 1146188-19-3|Molecular Weight: 449.80|Formula: C19H10ClF6NOS|Chemical Name: 4-[3, 5-bis(trifluoromethyl)phenyl]-3-(4-chlorobenzoyl)thiophen-2-amine|Smiles: NC1SC=C(C=1C(=O)C1C=CC(Cl)=CC=1)C1C=C(C=C(C=1)C(F)(F)F)C(F)(F)F|InChiKey: IVHJBJJHYFIUOA-UHFFFAOYSA-N|InChi: InChI=1S/C19H10ClF6NOS/c20-13-3-1-9(2-4-13)16(28)15-14(8-29-17(15)27)10-5-11(18(21,22)23)7-12(6-10)19(24,25)26/h1-8H,27H2|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: To be determined|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Vigabatrin} site|{Vigabatrin} Neuronal Signaling|{Vigabatrin} Protocol|{Vigabatrin} Purity|{Vigabatrin} custom synthesis|{Vigabatrin} Autophagy} |Shelf Life: ≥12 months if stored properly.{{Estramustine phosphate} web|{Estramustine phosphate} Cytoskeleton|{Estramustine phosphate} Protocol|{Estramustine phosphate} In Vivo|{Estramustine phosphate} custom synthesis|{Estramustine phosphate} Autophagy} |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.PMID:23819239 |Drug Formulation: To be determined|HS Tariff Code: 382200|References:|Draper-Joyce CJ, Bhola R, Wang J, Bhattarai A, Nguyen ATN, Cowie-Kent I, O’Sullivan K, Chia LY, Venugopal H, Valant C, Thal DM, Wootten D, Panel N, Carlsson J, Christie MJ, White PJ, Scammells P, May LT, Sexton PM, Danev R, Miao Y, Glukhova A, Imlach WL, Christopoulos A. Positive allosteric mechanisms of adenosine A1 receptor-mediated analgesia. Nature. 2021 Sep;597(7877):571-576.Products are for research use only. Not for human use.|

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SM-276001 is a potent selective TLR7 agonist that can induce antitumor immune responses. SM-276001 is an orally active interferon (IFN) inducer.|Product information|CAS Number: 473930-22-2|Molecular Weight: 327.38|Formula: C16H21N7O|Chemical Name: 6-amino-2-(butylamino)-9-[(6-methylpyridin-3-yl)methyl]-8,9-dihydro-7H-purin-8-one|Smiles: CC1=CC=C(CN2C(=O)NC3=C(N)N=C(NCCCC)N=C23)C=N1|InChiKey: UEIOLEMXCBOQAX-UHFFFAOYSA-N|InChi: InChI=1S/C16H21N7O/c1-3-4-7-18-15-21-13(17)12-14(22-15)23(16(24)20-12)9-11-6-5-10(2)19-8-11/h5-6,8H,3-4,7,9H2,1-2H3,(H,20,24)(H3,17,18,21,22)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : 125 mg/mL (381.82 mM; Need ultrasonic).|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.{{Sarolaner} medchemexpress|{Sarolaner} Anti-infection|{Sarolaner} Biological Activity|{Sarolaner} Description|{Sarolaner} manufacturer|{Sarolaner} Epigenetics} |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.{{Coelenterazine} site|{Coelenterazine} NF-κB|{Coelenterazine} Biological Activity|{Coelenterazine} Description|{Coelenterazine} custom synthesis|{Coelenterazine} Cancer} |Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|SM-276001 (1 nM-10 μM) dose-dependently activates NF-κB through human TLR7.PMID:23672196 |In Vivo:|SM-276001 demonstrates potent IFN-inducing activity at a dose of 0.1 mg/kg by oral administration in mice. Oral administration of SM-276001, leads to the induction of an inflammatory cytokine and chemokine milieu and to the activation of a diverse population of immune effector cells including T and B lymphocytes, NK and NKT cells. SM-276001 (3 mg/kg PO biweekly) significantly inhibits tumor growth in the Renca renal cell cancer and CT26 colorectal models. SM-276001 (orally; 0.1, 1 or 10 mg/kg) leads to the activation of a diverse population of spleen-resident immune effector cells in Balb/c and C57BL/6J mice. When administered at 1 mg/kg or greater, the plasma concentration of SM-276001 exceeds the MEC of 30 nM.|Products are for research use only. Not for human use.|

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GGTI-2418 is a highly potent, competitive, and selective geranylgeranyltransferase I (GGTase I) inhibitor. GGTI-2418 inhibits GGTase I and FTase activities with IC50s of 9.5 nM and 53 μM, respectively. GGTI-2418 also increases p27(Kip1) and induces significant regression of breast tumors.|Product information|CAS Number: 501010-06-6|Molecular Weight: 441.52|Formula: C23H31N5O4|Chemical Name: (2S)-2-{[(2S)-2-benzyl-4-[(5-methyl-1H-imidazol-4-yl)methyl]-3-oxopiperazine-1-carbonyl]amino}-4-methylpentanoic acid|Smiles: CC1NC=NC=1CN1CCN([C@@H](CC2C=CC=CC=2)C1=O)C(=O)N[C@@H](CC(C)C)C(O)=O|InChiKey: COLCNDRDBCLVOC-ICSRJNTNSA-N|InChi: InChI=1S/C23H31N5O4/c1-15(2)11-18(22(30)31)26-23(32)28-10-9-27(13-19-16(3)24-14-25-19)21(29)20(28)12-17-7-5-4-6-8-17/h4-8,14-15,18,20H,9-13H2,1-3H3,(H,24,25)(H,26,32)(H,30,31)/t18-,20-/m0/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : 125 mg/mL (283.11 mM; Need ultrasonic).|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|GGTI-2418 inhibits GGTase I and FTase activities with IC50s of 9.{{Lebrikizumab} site|{Lebrikizumab} Interleukin Related|{Lebrikizumab} Biological Activity|{Lebrikizumab} Purity|{Lebrikizumab} supplier|{Lebrikizumab} Epigenetics} 5±2.{{Adapalene} site|{Adapalene} Apoptosis|{Adapalene} Technical Information|{Adapalene} Formula|{Adapalene} manufacturer|{Adapalene} Epigenetics} 0 nM and 53±11 μM, respectively, a 5,600-fold selectivity toward inhibition of GGTase I versus FTase.PMID:24423657 GGTI-2418 demonstrates competitive inhibition of GGTase I against the H-Ras-CVLL protein with a Ki of 4.4±1.6 nM. GGTi-2418 (10-15 μM; 16 hours) treatment delocalizes FBXL2 and stabilizes IP3R3.|In Vivo:|GGTI-2418 (100 mg/kg daily or 200 mg/kg every third day; 15 days) significantly inhibits the growth of breast tumor xenografts in nude mice with MDA-MB-231 xenografts. GGTI-2418 (100 mg/kg daily; 5 days) induces regression of ErbB2-driven mammary tumors in ErbB2 transgenic mice. GGTI-2418 inhibits the geranylgeranylation of Rap1 and causes a dramatic decrease in S473 phosphorylation of Akt. GGTI-2418 also upregulates p27 levels in vivo.|Products are for research use only. Not for human use.|

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Sulfo-ara-F-NMN (CZ-48) is a mimetic of nicotinamide mononucleotide (NMN). Sulfo-ara-F-NMN acts selectively, activating SARM1 but inhibiting CD38 (IC50 around 10 μM). Sulfo-ara-F-NMN induces intracellular cyclic ADP-ribose (cADPR) production.|Product information|CAS Number: 1374663-29-2|Molecular Weight: 352.28|Formula: C11H14FN2O6PS|Chemical Name: 3-carbamoyl-1-[(2R,3S,4R,5R)-3-fluoro-4-hydroxy-5-({[hydroxy(oxido)sulfanylidene-λ⁵-phosphanyl]oxy}methyl)oxolan-2-yl]-1λ⁵-pyridin-1-ylium|Smiles: NC(=O)C1C=[N+](C=CC=1)[C@@H]1O[C@H](COP([O-])(O)=S)[C@@H](O)[C@@H]1F|InChiKey: SIQYQBAPGWSZQF-PKIKSRDPSA-N|InChi: InChI=1S/C11H14FN2O6PS/c12-8-9(15)7(5-19-21(17,18)22)20-11(8)14-3-1-2-6(4-14)10(13)16/h1-4,7-9,11,15H,5H2,(H3-,13,16,17,18,22)/t7-,8+,9-,11-/m1/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : 200 mg/mL (567.{{Nystatin} medchemexpress|{Nystatin} Apoptosis|{Nystatin} Protocol|{Nystatin} In Vitro|{Nystatin} supplier|{Nystatin} Cancer} 73 mM; Need ultrasonic).{{Lansoprazole} web|{Lansoprazole} Membrane Transporter/Ion Channel|{Lansoprazole} Protocol|{Lansoprazole} In Vivo|{Lansoprazole} custom synthesis|{Lansoprazole} Epigenetic Reader Domain} |Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.PMID:22664133 |Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|Sterile alpha and Toll/interleukin-1 receptor motif-containing 1 (SARM1) is an adaptor protein in the Toll-like receptor pathway. Sulfo-ara-F-NMN activates SARM1 to produce cyclic ADP-ribose and induces non-apoptotic cell death.|Products are for research use only. Not for human use.|

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TFAX 568, SE is an orange fluorescent dye and exhibits pH-insensitivity over a very broad range (pH in the 4-10).{{Pretomanid} web|{Pretomanid} Bacterial|{Pretomanid} Purity & Documentation|{Pretomanid} In Vivo|{Pretomanid} custom synthesis|{Pretomanid} Cancer} TFAX 568, SE yields exceptionally bright, photostable conjugates with proteins or antibodies (such as goat anti-mouse IgG).|Product information|CAS Number: 878549-44-1|Molecular Weight: 791.80|Formula: C37H33N3O13S2|Chemical Name: 6-(2-carboxy-4-{[(2,5-dioxopyrrolidin-1-yl)oxy]carbonyl}phenyl)-2,2,10,10-tetramethyl-4-(sulfomethyl)-8-(sulfonatomethyl)-2,10-dihydro-1H-13-oxa-1,11-diazapentacen-11-ium|Smiles: CC1(C)C=C(CS(O)(=O)=O)C2=CC3=C(C=C2N1)OC1=CC2=[NH+]C(C)(C)C=C(CS([O-])(=O)=O)C2=CC1=C3C1=CC=C(C=C1C(O)=O)C(=O)ON1C(=O)CCC1=O|InChiKey: DJLBKHHGFYXTRY-UHFFFAOYSA-N|InChi: InChI=1S/C37H33N3O13S2/c1-36(2)14-19(16-54(46,47)48)22-10-25-29(12-27(22)38-36)52-30-13-28-23(20(17-55(49,50)51)15-37(3,4)39-28)11-26(30)33(25)21-6-5-18(9-24(21)34(43)44)35(45)53-40-31(41)7-8-32(40)42/h5-6,9-15,38H,7-8,16-17H2,1-4H3,(H,43,44)(H,46,47,48)(H,49,50,51)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Sacubitril} site|{Sacubitril} Neprilysin|{Sacubitril} Protocol|{Sacubitril} Purity|{Sacubitril} supplier|{Sacubitril} Epigenetic Reader Domain} |Shelf Life: ≥12 months if stored properly.PMID:28038441 |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|Excitation maximum=560±20 nm; emission maximum=610±20 nm. Proteins labeled with the TFAX 568 dye is several-fold brighter than the same proteins labeled with lissamine rhodamine B dye.|Products are for research use only. Not for human use.|

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Fmoc-N-methyl-PEG3-CH2CH2COOH is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Fmoc-N-methyl-PEG3-CH2CH2COOH is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.|Product information|CAS Number: 1807518-77-9|Molecular Weight: 457.52|Formula: C25H31NO7|Chemical Name: 3-(2-{2-[2-({[(9H-fluoren-9-yl)methoxy]carbonyl}(methyl)amino)ethoxy]ethoxy}ethoxy)propanoic acid|Smiles: CN(CCOCCOCCOCCC(O)=O)C(=O)OCC1C2=CC=CC=C2C2=CC=CC=C21|InChiKey: JKEBDIJQSKVIID-UHFFFAOYSA-N|InChi: InChI=1S/C25H31NO7/c1-26(11-13-31-15-17-32-16-14-30-12-10-24(27)28)25(29)33-18-23-21-8-4-2-6-19(21)20-7-3-5-9-22(20)23/h2-9,23H,10-18H2,1H3,(H,27,28)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Fmoc-Asn(Trt)-OH} site|{Fmoc-Asn(Trt)-OH} {Biochemical Assay Reagents}|{Fmoc-Asn(Trt)-OH} Biological Activity|{Fmoc-Asn(Trt)-OH} In Vivo|{Fmoc-Asn(Trt)-OH} manufacturer|{Fmoc-Asn(Trt)-OH} Epigenetics} |Shelf Life: ≥12 months if stored properly.PMID:23756629 |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.|Products are for research use only. Not for human use.|

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Bis-PEG10-acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.|Product information|CAS Number: 2055023-26-0|Molecular Weight: 558.61|Formula: C24H46O14|Chemical Name: 4,7,10,13,16,19,22,25,28,31-decaoxatetratriacontanedioic acid|Smiles: OC(=O)CCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCC(O)=O|InChiKey: PPYUGGOOBJIZHK-UHFFFAOYSA-N|InChi: InChI=1S/C24H46O14/c25-23(26)1-3-29-5-7-31-9-11-33-13-15-35-17-19-37-21-22-38-20-18-36-16-14-34-12-10-32-8-6-30-4-2-24(27)28/h1-22H2,(H,25,26)(H,27,28)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.PMID:32180353 |Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.|Products are for research use only. Not for human use.|

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N-(Mal-PEG6)-N-bis(PEG7-TCO) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.PMID:23916866 |Product information|CAS Number: 2093152-84-0|Molecular Weight: 1652.95|Formula: C78H137N7O30|Chemical Name: cyclooct-4-en-1-yl N-{14-[(2-{2-[2-(2-{N-[2-(2-{2-[2-(1-{[(cyclooct-4-en-1-yloxy)carbonyl]amino}-3,6,9,12-tetraoxapentadecan-15-amido)ethoxy]ethoxy}ethoxy)ethyl]-1-[3-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)propanamido]-3,6,9,12,15,18-hexaoxahenicosan-21-amido}ethoxy)ethoxy]ethoxy}ethyl)carbamoyl]-3,6,9,12-tetraoxatetradecan-1-yl}carbamate|Smiles: O=C(CCOCCOCCOCCOCCOCCOCCNC(=O)CCN1C(=O)C=CC1=O)N(CCOCCOCCOCCNC(=O)CCOCCOCCOCCOCCNC(=O)OC1CCC=CCCC1)CCOCCOCCOCCNC(=O)CCOCCOCCOCCOCCNC(=O)OC1CCC=CCCC1 |c:71,112||InChiKey: LXEACWVJIHRBDM-LEWNYYKSSA-N|InChi: InChI=1S/C78H137N7O30/c86-71(17-26-85-75(90)15-16-76(85)91)79-21-32-97-44-54-109-64-66-113-68-67-112-65-61-106-51-41-96-31-20-74(89)84(27-37-102-47-57-107-52-42-98-33-22-80-72(87)18-29-94-39-49-104-59-62-110-55-45-100-35-24-82-77(92)114-69-11-7-3-1-4-8-12-69)28-38-103-48-58-108-53-43-99-34-23-81-73(88)19-30-95-40-50-105-60-63-111-56-46-101-36-25-83-78(93)115-70-13-9-5-2-6-10-14-70/h1-3,5,15-16,69-70H,4,6-14,17-68H2,(H,79,86)(H,80,87)(H,81,88)(H,82,92)(H,83,93)/b3-1-,5-2-|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.|Products are for research use only. Not for human use.|

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Methylamino-PEG1-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.|Product information|CAS Number: 1807521-03-4|Molecular Weight: 203.28|Formula: C10H21NO3|Chemical Name: tert-butyl 3-[2-(methylamino)ethoxy]propanoate|Smiles: CNCCOCCC(=O)OC(C)(C)C|InChiKey: BDFGXPFIPPZYGO-UHFFFAOYSA-N|InChi: InChI=1S/C10H21NO3/c1-10(2,3)14-9(12)5-7-13-8-6-11-4/h11H,5-8H2,1-4H3|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.|Products are for research use only. Not for human use.|

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Hck-IN-1 (compound B9), a diphenylpyrazolo compound, is a selective Nef-dependent Hck inhibitor with IC50s of 2.8 μM, >20 μM for Nef:Hck complex and Hck, respectively. Hck-IN-1 is a direct and wide HIV-1 Nef antagonists with an IC50 of 100-300 nM for wild-type HIV-1 replication. Hck-IN-1 binds pocket residue Asn126 and has anti-retroviral activity.|Product information|CAS Number: 1473404-51-1|Molecular Weight: 402.81|Formula: C16H11ClN6O3S|Chemical Name: 4-[2-(3-chlorophenyl)diazen-1-yl]-3-(4-nitrophenyl)-5-oxo-2,5-dihydro-1H-pyrazole-1-carbothioamide|Smiles: NC(=S)N1NC(=C(N=NC2=CC(Cl)=CC=C2)C1=O)C1C=CC(=CC=1)[N+]([O-])=O|InChiKey: LEQSBTDRMOZWRP-FMQUCBEESA-N|InChi: InChI=1S/C16H11ClN6O3S/c17-10-2-1-3-11(8-10)19-20-14-13(21-22(15(14)24)16(18)27)9-4-6-12(7-5-9)23(25)26/h1-8,21H,(H2,18,27)/b20-19+|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : 12.5 mg/mL (31.03 mM; Need ultrasonic).|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.{{MDTF} MedChemExpress|{MDTF} Antibody-drug Conjugate/ADC Related|{MDTF} Technical Information|{MDTF} Formula|{MDTF} manufacturer|{MDTF} Autophagy} |Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|Hck-IN-1 (compound B9) shows weak activity against other Src-family members in vitro, with IC50 values >20 μM for c-Src, Lck and Lyn.PMID:25027343 B9 (1 μM; 8 days) completely inhibits Nef-dependent SFK activation at a concentration of 1.0 μM. Hck-IN-1 (0.1, 0.3, 1, 3 μM) also inhibits Nef-mediated enhancement of HIV-1 infectivity in a concentration-dependent manner in the reporter cell line, TZM-bl. Hck-IN-1 inhibits the replication of all eleven HIV-1 Nef chimeras with IC50 values of ~ 300 nM in CEM-T4 cells, demonstrating that the compound is broadly active against HIV replication supported by a wide range of HIV-1 Nef proteins.|Products are for research use only. Not for human use.|

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4-Chlorocatechol is a major degradation product of 4-chloro-2-aminophenol (4C2AP).{{Streptavidin Protein} MedChemExpress|{Streptavidin Protein} Biological Activity|{Streptavidin Protein} Purity|{Streptavidin Protein} supplier|{Streptavidin Protein} Epigenetics} 4-Chlorocatechol is also a substrate for catechol 1,2-dioxygenases and chlorocatechol dioxygenase.|Product information|CAS Number: 2138-22-9|Molecular Weight: 144.56|Formula: C6H5ClO2|Chemical Name: 4-chlorobenzene-1,2-diol|Smiles: OC1=CC(Cl)=CC=C1O|InChiKey: WWOBYPKUYODHDG-UHFFFAOYSA-N|InChi: InChI=1S/C6H5ClO2/c7-4-1-2-5(8)6(9)3-4/h1-3,8-9H|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : 100 mg/mL (691.PMID:28630660 75 mM; Need ultrasonic).|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|

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Febuxostat dicarboxylic acid impurity is an impurity of Febuxostat. Febuxostat is selective xanthine oxidase inhibitor with a Ki of 0.6 nM.|Product information|CAS Number: 1239233-87-4|Molecular Weight: 335.37|Formula: C16H17NO5S|Chemical Name: 2-[3-carboxy-4-(2-methylpropoxy)phenyl]-4-methyl-1,3-thiazole-5-carboxylic acid|Smiles: CC1N=C(SC=1C(O)=O)C1=CC(=C(C=C1)OCC(C)C)C(O)=O|InChiKey: WSCLTDCYZOTAKS-UHFFFAOYSA-N|InChi: InChI=1S/C16H17NO5S/c1-8(2)7-22-12-5-4-10(6-11(12)15(18)19)14-17-9(3)13(23-14)16(20)21/h4-6,8H,7H2,1-3H3,(H,18,19)(H,20,21)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Dodecyltrimethylammonium} medchemexpress|{Dodecyltrimethylammonium} {Biochemical Assay Reagents}|{Dodecyltrimethylammonium} Biological Activity|{Dodecyltrimethylammonium} Purity|{Dodecyltrimethylammonium} supplier|{Dodecyltrimethylammonium} Epigenetics} |Shelf Life: ≥12 months if stored properly.{{24(S)-Hydroxycholesterol} medchemexpress|{24(S)-Hydroxycholesterol} Membrane Transporter/Ion Channel|{24(S)-Hydroxycholesterol} Protocol|{24(S)-Hydroxycholesterol} Formula|{24(S)-Hydroxycholesterol} supplier|{24(S)-Hydroxycholesterol} Epigenetic Reader Domain} |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.PMID:23577779 |Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|

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7-Hydroxy-4-methyl-8-nitrocoumarin is a coumarin derivative.|Product information|CAS Number: 19037-69-5|Molecular Weight: 221.17|Formula: C10H7NO5|Chemical Name: 7-hydroxy-4-methyl-8-nitro-2H-chromen-2-one|Smiles: CC1=CC(=O)OC2=C(C(O)=CC=C21)[N+]([O-])=O|InChiKey: BGUBUSIGKOWDPO-UHFFFAOYSA-N|InChi: InChI=1S/C10H7NO5/c1-5-4-8(13)16-10-6(5)2-3-7(12)9(10)11(14)15/h2-4,12H,1H3|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Oligomycin} medchemexpress|{Oligomycin} Metabolic Enzyme/Protease|{Oligomycin} Purity & Documentation|{Oligomycin} Description|{Oligomycin} manufacturer|{Oligomycin} Epigenetics} |Shelf Life: ≥12 months if stored properly.{{Caspofungin} site|{Caspofungin} Antibiotic|{Caspofungin} Purity & Documentation|{Caspofungin} Description|{Caspofungin} custom synthesis|{Caspofungin} Autophagy} |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.PMID:23991096 |Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|

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D-Mannuronic acid sodium, isolated from Macrocystis pyrifera, has the potential in autoimmune encephalomyelitis (EAE), adjuvant induced arthritis (AIA), nephrotic syndrome, and acute glomerulonephritis studies.{{Benzbromarone} site|{Benzbromarone} Cell Cycle/DNA Damage|{Benzbromarone} Technical Information|{Benzbromarone} Formula|{Benzbromarone} manufacturer|{Benzbromarone} Cancer} |Product information|CAS Number: 921-56-2|Molecular Weight: 216.{{Paeoniflorin} web|{Paeoniflorin} Cell Cycle/DNA Damage|{Paeoniflorin} Technical Information|{Paeoniflorin} Formula|{Paeoniflorin} custom synthesis|{Paeoniflorin} Autophagy} 12|Formula: C6H9NaO7|Chemical Name: sodium (2S,3S,4S,5S)-2,3,4,5-tetrahydroxy-6-oxohexanoate|Smiles: [Na+].PMID:23341580 [O-]C(=O)[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)C=O|InChiKey: WNFHGZLVUQBPMA-MHFWOIHZSA-M|InChi: InChI=1S/C6H10O7.Na/c7-1-2(8)3(9)4(10)5(11)6(12)13;/h1-5,8-11H,(H,12,13);/q;+1/p-1/t2-,3-,4+,5+;/m1./s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: H2O : 250 mg/mL (1156.76 mM; Need ultrasonic).|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|

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Cy5-SE (Cy5 NHS Ester) is a reactive dye for the labeling of amino-groups in peptides, proteins, and oligonucleotides.{{Ipilimumab} MedChemExpress|{Ipilimumab} Immunology/Inflammation|{Ipilimumab} Protocol|{Ipilimumab} References|{Ipilimumab} custom synthesis|{Ipilimumab} Epigenetics} This dye requires small amount of organic co-solvent (such as DMF or DMSO) to be used in labeling reaction. This reagent is ideal for very cost-efficient labeling of soluble proteins, as well as all kinds of peptides and oligonucleotides. This reagent also works well in organic solvents for small molecule labeling.Excitation (nm):649, Emission (nm): 670.|Product information|CAS Number: 146368-14-1|Molecular Weight: 753.88|Formula: C37H43N3O10S2|Chemical Name: 1-{6-[(2,5-dioxopyrrolidin-1-yl)oxy]-6-oxohexyl}-2-[5-(1-ethyl-3,3-dimethyl-5-sulfonato-2,3-dihydro-1H-indol-2-ylidene)penta-1,3-dien-1-yl]-3,3-dimethyl-5-sulfo-3H-indol-1-ium|Smiles: CCN1C(=CC=CC=CC2=[N+](CCCCCC(=O)ON3C(=O)CCC3=O)C3=CC=C(C=C3C2(C)C)S(O)(=O)=O)C(C)(C)C2=CC(=CC=C12)S([O-])(=O)=O|InChiKey: WXWLHDCCGVWTDZ-UHFFFAOYSA-N|InChi: InChI=1S/C37H43N3O10S2/c1-6-38-29-18-16-25(51(44,45)46)23-27(29)36(2,3)31(38)13-9-7-10-14-32-37(4,5)28-24-26(52(47,48)49)17-19-30(28)39(32)22-12-8-11-15-35(43)50-40-33(41)20-21-34(40)42/h7,9-10,13-14,16-19,23-24H,6,8,11-12,15,20-22H2,1-5H3,(H-,44,45,46,47,48,49)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : 25 mg/mL (33.{{SKI II} medchemexpress|{SKI II} Immunology/Inflammation|{SKI II} Biological Activity|{SKI II} Data Sheet|{SKI II} custom synthesis|{SKI II} Epigenetic Reader Domain} 16 mM; Need ultrasonic).PMID:23891445 |Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|

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N-Benzyl-N-bis-PEG2 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.{{Idarubicin} web|{Idarubicin} Cell Cycle/DNA Damage|{Idarubicin} Protocol|{Idarubicin} References|{Idarubicin} custom synthesis|{Idarubicin} Epigenetic Reader Domain} |Product information|CAS Number: 119580-47-1|Molecular Weight: 283.36|Formula: C15H25NO4|Chemical Name: 2-(2-{benzyl[2-(2-hydroxyethoxy)ethyl]amino}ethoxy)ethan-1-ol|Smiles: OCCOCCN(CC1C=CC=CC=1)CCOCCO|InChiKey: HBHHHXUOMCTWCK-UHFFFAOYSA-N|InChi: InChI=1S/C15H25NO4/c17-8-12-19-10-6-16(7-11-20-13-9-18)14-15-4-2-1-3-5-15/h1-5,17-18H,6-14H2|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.PMID:25558565 |Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.|Products are for research use only. Not for human use.|

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NH2-Ph-C4-acid-NH2-Me (PROTAC Linker 31) is an alkyl chain-based PROTAC linker can be used in the synthesis of PROTACs.|Product information|CAS Number: 1263819-48-2|Molecular Weight: 222.28|Formula: C12H18N2O2|Chemical Name: (2S,4R)-4-amino-5-(4-aminophenyl)-2-methylpentanoic acid|Smiles: C[C@@H](C[C@@H](N)CC1C=CC(N)=CC=1)C(O)=O|InChiKey: JPGXUEFAQWNCEO-GZMMTYOYSA-N|InChi: InChI=1S/C12H18N2O2/c1-8(12(15)16)6-11(14)7-9-2-4-10(13)5-3-9/h2-5,8,11H,6-7,13-14H2,1H3,(H,15,16)/t8-,11+/m0/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Linagliptin} site|{Linagliptin} Ferroptosis|{Linagliptin} Technical Information|{Linagliptin} References|{Linagliptin} manufacturer|{Linagliptin} Autophagy} |Shelf Life: ≥12 months if stored properly.{{Tacrolimus} web|{Tacrolimus} FKBP|{Tacrolimus} Purity & Documentation|{Tacrolimus} Purity|{Tacrolimus} manufacturer|{Tacrolimus} Epigenetics} |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.PMID:25040798 |Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.|Products are for research use only. Not for human use.|

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Fibrin, isolated from bovine blood, is an insoluble protein produced in response to bleeding.{{Anti-Mouse IL-1b Antibody} web|{Anti-Mouse IL-1b Antibody} Interleukin Related|{Anti-Mouse IL-1b Antibody} Protocol|{Anti-Mouse IL-1b Antibody} References|{Anti-Mouse IL-1b Antibody} custom synthesis|{Anti-Mouse IL-1b Antibody} Epigenetics} Fibrin is the major component of the blood clot and is used for coagulation.PMID:25429455 |Product information|CAS Number: 9001-31-4|Molecular Weight: 145.16|Formula: C5H11N3O2|Chemical Name: 2-amino-N-[(methylcarbamoyl)methyl]acetamide|Smiles: CNC(=O)CNC(=O)CN|InChiKey: BWGVNKXGVNDBDI-UHFFFAOYSA-N|InChi: InChI=1S/C5H11N3O2/c1-7-5(10)3-8-4(9)2-6/h2-3,6H2,1H3,(H,7,10)(H,8,9)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|

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2,3-Butanedione-2-monoxime is a myosin ATPase inhibitor. Myosin, an ATPase, can convert chemical energy into directed movement and is regarded as a molecular motor. Myosin has various shapes and sizes. More than 11 myosin classes have been identified, and more will be found. The common feature of all of these molecules is a section close to the N terminus, which can be identified as a motor domain. In vitro: 2,3-Butanedione-2-monoxime (BDM), a general probe of myosin function, was widely used in muscle research as a low-affinity but specific chemical phosphatase that could reversibly inhibit the myosin cross-bridge cycle. It was found that wild-type cells treated with BDM at 20 mM for around two generation times were smaller than untreated controls and showed a septation index about twice that observed in the absence of the inhibitor.{{Olanzapine} MedChemExpress|{Olanzapine} Autophagy|{Olanzapine} Purity & Documentation|{Olanzapine} Data Sheet|{Olanzapine} supplier|{Olanzapine} Epigenetics} Moreover, the organization of actin at the cell poles was disorganized in the presence of BDM, however, cells formed a cytokinetic actin ring.{{Treosulfan} site|{Treosulfan} DNA Alkylator/Crosslinker|{Treosulfan} Technical Information|{Treosulfan} Purity|{Treosulfan} manufacturer|{Treosulfan} Epigenetics} In addition, when nitrogen-starved stationary-phase cells were reinoculated into fresh medium in the presence of BDM, the time taken to repolarize the actin cytoskeleton and to resume the characteristic vegetative cell shape were both delayed substantially .PMID:23290930 In vivo: So far, there is no animal in vivo data reported. Clinical trial: So far, no clinical study has been conducted.|Product information|CAS Number: 57-71-6|Molecular Weight: 101.10|Formula: C4H7NO2|Chemical Name: (3E)-3-(hydroxyimino)butan-2-one|Smiles: C/C(=N\O)/C(C)=O|InChiKey: FSEUPUDHEBLWJY-HWKANZROSA-N|InChi: InChI=1S/C4H7NO2/c1-3(5-7)4(2)6/h7H,1-2H3/b5-3+|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|

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Product information|CAS Number: 20813-76-7|Molecular Weight: 536.{{Tazarotene} MedChemExpress|{Tazarotene} Autophagy|{Tazarotene} Biological Activity|{Tazarotene} In Vitro|{Tazarotene} supplier|{Tazarotene} Epigenetics} 29|Formula: C10H27N4Na2O16P|Chemical Name: disodium octahydrate [(2R,3S,4R,5R)-3,4-dihydroxy-5-(6-oxo-6,9-dihydro-1H-purin-9-yl)oxolan-2-yl]methyl phosphate|Smiles: O.{{Ciprofloxacin} medchemexpress|{Ciprofloxacin} Antibiotic|{Ciprofloxacin} Biological Activity|{Ciprofloxacin} Description|{Ciprofloxacin} manufacturer|{Ciprofloxacin} Epigenetics} O.PMID:36014399 O.O.O.O.O.O.[Na+].[Na+].[O-]P([O-])(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)N1C=NC2=C1N=CNC2=O|InChiKey: QKWLBOYKTJDMLH-NAGQJCCQSA-L|InChi: InChI=1S/C10H13N4O8P.2Na.8H2O/c15-6-4(1-21-23(18,19)20)22-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17;;;;;;;;;;/h2-4,6-7,10,15-16H,1H2,(H,11,12,17)(H2,18,19,20);;;8*1H2/q;2*+1;;;;;;;;/p-2/t4-,6-,7-,10-;;;;;;;;;;/m1………./s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|

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Product information|CAS Number: 114289-47-3|Molecular Weight: 393.PMID:24278086 56|Formula: C23H39NO4|Chemical Name: 2,2-dimethyl-N-(2,4,6-trimethoxyphenyl)dodecanamide|Smiles: CCCCCCCCCCC(C)(C)C(=O)NC1C(=CC(=CC=1OC)OC)OC|InChiKey: WAFNZAURAWBNDZ-UHFFFAOYSA-N|InChi: InChI=1S/C23H39NO4/c1-7-8-9-10-11-12-13-14-15-23(2,3)22(25)24-21-19(27-5)16-18(26-4)17-20(21)28-6/h16-17H,7-15H2,1-6H3,(H,24,25)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|

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The histone H3 lysine 27 (H3K27) demethylase JMJD3 plays important roles in the transcriptional regulation of cell differentiation, development, the inflammatory response, and cancer.{{Anti-Mouse IL-1R Antibody} MedChemExpress|{Anti-Mouse IL-1R Antibody} Immunology/Inflammation|{Anti-Mouse IL-1R Antibody} Technical Information|{Anti-Mouse IL-1R Antibody} References|{Anti-Mouse IL-1R Antibody} custom synthesis|{Anti-Mouse IL-1R Antibody} Epigenetic Reader Domain} ,.{{Flucytosine} web|{Flucytosine} Antibiotic|{Flucytosine} Technical Information|{Flucytosine} Description|{Flucytosine} manufacturer|{Flucytosine} Cancer} GSK-J4 is a cell-permeable prodrug which is modified by intracellular esterases to give GSK-J1, an inhibitor of JMJD3.PMID:35991869 GSK-J5 is a pyridine regio-isomer of GSK-J4. Like GSK-J4, this isomer is cell-permeable and hydrolyzed to a free base.3 However, the free base is a weak inhibitor of JMJD3 (IC50 > 100 μM), making it an ideal inactive control molecule for elucidating the functional role of JMJD3 inhibition. Reference: . Agger, K., Cloos, P.A.C., Christensen, J., et al. UTX and JMJD3 are histone H3K27 demethylases involved in HOX gene regulation and development. Nat.Lett. 449(7163), 731-734 (2011). . Hübner, M.R., and Spector, D.L. Role of H3K27 demethylases Jmjd3 and UTX in transcriptional regulation. Cold Spring Harb.Symp.Quant.Biol. 75, 43-49 (2010). . Kruidenier, L., Chung, C.W., Cheng, Z., et al. A selective jumonji H3K27 demethylase inhibitor modulates the proinflammatory macrophage response. Nature 488, 404-408 (2012).|Product information|CAS Number: 1394854-51-3|Molecular Weight: 417.50|Formula: C24H27N5O2|Chemical Name: ethyl 3-{[2-(pyridin-3-yl)-6-(2,3,4,5-tetrahydro-1H-3-benzazepin-3-yl)pyrimidin-4-yl]amino}propanoate|Smiles: CCOC(=O)CCNC1=CC(=NC(=N1)C1=CN=CC=C1)N1CCC2=CC=CC=C2CC1|InChiKey: LQPGVGSKBNXQDU-UHFFFAOYSA-N|InChi: InChI=1S/C24H27N5O2/c1-2-31-23(30)9-13-26-21-16-22(28-24(27-21)20-8-5-12-25-17-20)29-14-10-18-6-3-4-7-19(18)11-15-29/h3-8,12,16-17H,2,9-11,13-15H2,1H3,(H,26,27,28)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|

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Product information|CAS Number: 29331-92-8|Molecular Weight: 254.28|Formula: C15H14N2O2|Chemical Name: (9R)-9-hydroxy-2-azatricyclo[9.4.0.0³,⁸]pentadeca-1(15),3,5,7,11,13-hexaene-2-carboxamide|Smiles: NC(=O)N1C2=CC=CC=C2C[C@@H](O)C2=CC=CC=C12|InChiKey: BMPDWHIDQYTSHX-CQSZACIVSA-N|InChi: InChI=1S/C15H14N2O2/c16-15(19)17-12-7-3-1-5-10(12)9-14(18)11-6-2-4-8-13(11)17/h1-8,14,18H,9H2,(H2,16,19)/t14-/m1/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|

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A 841720 is a novel non-competitive antagonist of metabotropic glutamate receptor 1 (mGluR1), with an IC50 value of 10.7 nM to 10 µM L-glutamate-induced calcium release at human mGluR1 receptors . Glutamate as the major excitatory neurotransmitter in the central nervous system functions through two types of receptors, ionotropic glutamate receptors and metabotropic glutamate receptors (mGluRs).{{Sirukumab} medchemexpress|{Sirukumab} Interleukin Related|{Sirukumab} Biological Activity|{Sirukumab} Formula|{Sirukumab} supplier|{Sirukumab} Autophagy} MGluRs includes group I mGluRs (mGluR1 and mGluR5 receptors), group II (mGluR2 and mGluR3 receptors) and group III (mGluR4, 6, 7, 8 receptors) .PMID:29844565 In cells, agonist-induced calcium release was concentration-dependently inhibited by A 841720 in a human mGluR5 receptor FLIPR functional assay. But the IC50 value was just 343 nM. In cells expressing recombinant mGluR5 receptors, A 841720 did not block agonist-induced response. In the human mGluR1 receptor FLIPR assay, the log concentration-response curve was shifted by A 841720 at 10 nM to the right. A 841720 at increasing concentrations profoundly reduced the amplitude of L-quisqualate-evoked calcium release. A 841720 at 30 nM reduced the maximal agonist-induced response by 38%. L-quisqualate-induced response was completely abolished by A 841720 at 100 nM . In a water maze test, all rats gradually learned to locate the submerged platform. Treatment with A 841720 significantly slowered rats to find the platform than vehicle control rats. Rats treated with A 841720 at both 30 and 100 µmol/kg doses not only significantly traveled longer distance to find the hidden platform, but also significantly spent longer time to reach the platform .|Product information|CAS Number: 869802-58-4|Molecular Weight: 343.45|Formula: C17H21N5OS|Chemical Name: 5-(azepan-1-yl)-13-(dimethylamino)-8-thia-3,5,10-triazatricyclo[7.4.0.0²,⁷]trideca-1(13),2(7),3,9,11-pentaen-6-one|Smiles: CN(C)C1C=CN=C2SC3C(=O)N(C=NC=3C2=1)N1CCCCCC1|InChiKey: GYWGXEGOXODOQU-UHFFFAOYSA-N|InChi: InChI=1S/C17H21N5OS/c1-20(2)12-7-8-18-16-13(12)14-15(24-16)17(23)22(11-19-14)21-9-5-3-4-6-10-21/h7-8,11H,3-6,9-10H2,1-2H3|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|