tions, BPA can also show acute toxicity toward aquatic organisms and carcinogenic properties [56]. In turn, members of the loved ones of polychlorinated dibenzodioxins (PCDDs) can bioaccumulate in humans and wildlife due to their lipophilic properties and may result in developmental disturbances and cancer. The European Union Water Framework Directive [57] and also the Directive of the European Parliament and Council (2013/39/EU) concerning priority substances inside the field of water policy (Directive EQS) list 45 substances representing a critical GSK-3α medchemexpress threat to aquatic environments and to humans, which need to be removed from aquatic environments, such as PCBs and PCDDs. Not too long ago, the potential for improvement of removal of BPA in CDK9 Biological Activity planta has been shown by endophytic Pantoea anantis in mixture with its host plant Dracaena sanderiana. Due to the activities with the plants and microorganisms, such physicochemical indicator parameters as pH, COD, BOD, TDS, conductivity, and salinity were decreased after 5 days of the experimental period having a decrease in BPA levels [56,58]. Bioremediation on the most toxic dioxin congener 2,three,7,8-TCDD was shown inside a study involving the endophytic bacterium Burkholderia cenocapacia 869T2 isolated from roots of vetiver grass. In an in vitro assay, it was capable of TCDD degradation by almost 95 immediately after one week of aerobic incubation. Typically, within the bioremediation of dioxins by bacteria, angular dioxygenase, cytochrome P450, lignin peroxidase, and dehalogenases are called significant dioxin-metabolizing enzymes. Through transcriptomic analysis of strain 869T2 exposed to TCDD, quite a few catabolic genes involved in dioxin metabolism have been detected with high gene expressions within the presence of TCDD. Assays with cloned l-2-haloacid dehalogenase (2-HAD) indicated that it could play a pivotal part in TCDD dehalogenation [59].Int. J. Mol. Sci. 2021, 22,eight of2.4. Removal of Agrochemicals–Pesticides/Herbicides/Insecticides/Fertilizers Despite some good impact in the use of herbicides, pesticides, and insecticides on an increase in crop production, you will find reports on several damaging effects of their use like selection for resistant weeds, production of toxic metabolites from their degradation, modifications in soil microbial communities and biogeochemical cycles, alterations in plant nutrition and soil fertility, and persistent environmental contamination. The chemical structures of active ingredients present in such herbicide formulations, such as oxygen, hydroxide, sulfonyl, phosphoric acid, amine, and chlorine, differentially affect environmental matrices and a lot of non-target plant and animal organisms, including humans [60]. Despite the fact that such normally employed pesticides as 2,4-dichlorophenoxyacetic acid (two,4-D) and atrazine usually are not listed by the Stockholm Convention as POPs, they have been listed by the US-EPA as toxic and are related with human wellness risks. To overcome these limitations and mitigate their influence, some endophytic bacteria were used for the transformation of those substances by means of xenobiotic degradation pathways. For example, an endophytic B. megaterium strain obtained in the roots of tobacco degraded 93 of quinclorac, i.e., a herbicide made use of to manage several grass species in rice, canola, barley, corn, and sorghum, and alleviated its phytotoxicity [61]. Detoxification of atrazine, that is recognized as a significant contaminant of surface and groundwater, by endophytic Streptomyces sp. isolated from sugarcane was con