dowska1; E. Odnoczko2; B. ETB Activator drug Baran2; J. Windyga1,two; A. Calcium Channel Inhibitor web Gwozdowska; E. Odnoczko; B. Baran; 1;two J. WindygaDepartment of Haemostasis Disorders and Internal Medicine, Institute Department of Haemostasis and Metabolic Issues, Institute ofof Hematology and Transfusion Medicine (IHTM), Warsaw, Poland;Hematology and Transfusion Medicine (IHTM), Warsaw, Poland Background: Cerebral venous sinus thrombosis (CVST) is usually a rare manifestation of venous thromboembolism (VTE). The estimated CVST incidence in adults is 2 per million cases. Amongst prospective threat components for CVST are congenital and acquired thrombophilia. Aims: Evaluation with the prevalence of congenital thrombophilia, antiphospholipid syndrome (APS) along with other danger components for CVST in a massive cohort of individuals. Solutions: Our study comprised 255 sufferers with definitive diagnosis of CVST: 188 girls and 67 males, mean age 39 (143) years. Healthcare interview included family history of VTE, age and presence of environmental thrombosis threat variables (pregnancy, delivery, oral contraceptives and hormone replacement therapy (OCPs/HRT), infection, neoplasm) at CVST diagnosis. Laboratory tests comprised thrombophilic defects: deficiency of antithrombin, protein C and protein S as well as issue V Leiden and prothrombin gene mutation G20210A and antiphospholipid antibodies.Conclusions: This cohort within the Brazil’s Northeast had extra women with CAT, higher prices of PE along with other critical risk elements including hormone use and obesity. Enoxaparin (low molecular weight heparin) was still the primary decision for initial therapy, but direct oral anticoagulants (DOACs) have been more prevalent inside the therapy of cancer sufferers.890 of|ABSTRACTResults: Forty-two (16.five ) individuals had congenital thrombophilia and fourteen (5.5 ) had been diagnosed with APS. In 11 (4.three ) sufferers myeloproliferative neoplasms (MPN) was investigated as a consequence of total blood count aberrations and in 9 of them (3.5 of all sufferers) JAK-2 V617F optimistic MPN was confirmed (Essential Thrombocytemia (ET) in 5, Policythemia Vera (PV) in 1, ET/Primary Myelofibrosis (PMF) in 1, PMF in 1 and MF post PV in 1). One patient had triple-negative ET and one Myelodysplastic Syndrome/MPN. Two individuals (0.eight ) had congenital thrombophilia coexistent with MPN. In the time of CVST diagnosis 86/188 (45.7 ) women were taking OCPs/HRT, while in twenty-nine (15.4 ) females CVST occurred during pregnancy or at delivery. Thirty one particular sufferers (12.1 ) reported a constructive family members history of VTE. Conclusions: Inside the study individuals the principle risk factors for CVST have been oral contraceptives and hormone replacement therapy also as congenital thrombophilia, pregnancy and delivery.thromboprophylaxis and 12 (six ) received therapeutic anticoagulant. There was no considerable difference in DVT between higher danger and low risk group (eight.9 vs. 6.3 , respectively). There was no significant difference in mortality in these with and with no DVT. No risk element was linked with the improvement of DVT. Conclusions: Despite low price of thromboprophylaxis, we located a low incidence of DVT. Pharmacological thromboprophylaxis in our crucial care unit should be discussed individually.PB1214|Low Awareness of Venous Thromboembolism among the Basic Population: A Call for Elevated Public Enlightenment Applications H. Okoye1; T. Nwagha1; E. Ezigbo2; O. Nnachi3; O. Obodo 4; O. Nnachi3; N. Amu4; I. AnigboguDepartment of Haematology and Immunology, College of Medicine,University of Nigeria, Enugu, Nigeria; 2Thrombosi