S. Preliminary results Ten in the essential 40 interviewees have so far been recruited. Preliminary analysis confirms that survivors practical experience a range of morbidity not nicely captured by professionally suggested measures, and that pre-existing illness is definitely an critical issue in both coping with new morbidity superimposed by crucial illness, and in marshalling support. The approach of rehabilitation seems to possess significant effects on perceptions of recovery, self-management tactics, and perceptions of HRQoL. Conclusions This qualitative enquiry has already supplied, and can continue to provide, new and buy RAD51 Inhibitor B02 clinically relevant insights into patients’ experiences of morbidity, the processes of rehabilitation, recovery and perceived HRQoL following discharge into the community.P493 Excellent of life ahead of intensive care unit admission is usually a robust predictor of survivalP Spronk1, J Hofhuis1, H van Stel2, J Rommes1, A Schrijvers2, J Bakker3 1Gelre Ziekenhuizen Location Lukas, Apeldoorn, The PubMed ID:http://www.ncbi.nlm.nih.gov/pubmed/20799856 Netherlands; 2Julius Institute, Utrecht, The Netherlands; 3Erasmus MC, Rotterdam, The Netherlands Vital Care 2007, 11(Suppl 2):P493 (doi: 10.1186/cc5653) Objective To examine no matter if health-related excellent of life (HRQOL) before admission for the ICU is often used as a predictor of mortality Design and style and approaches A potential cohort study in an universityaffiliated teaching hospital. Individuals admitted towards the ICU for >48 hours have been included. Close relatives completed the Short-form 36 (SF-36) within the initial 48 hours of admission to assess the premorbid HRQOL from the patient. Mortality was evaluated from ICU admittance till 6 months soon after ICU discharge. Logistic regression and ROC analysis had been made use of to assess the predictive worth for mortality of the 1st general overall health question from the SF-36 (`in general would you say the well being of the relative is fantastic, very good, excellent, fair or poor’), at the same time as HRQOL measured by the full SF-36. The Acute Physiologic and Chronic Well being Evaluation (APACHE) II score was utilized as an accepted mortality prediction model in ICU sufferers. Three models had been constructed which includes the HRQOL (model A), APACHE II score (model B), or both (model C) to age and gender. Percentages of appropriate survival/death predictions have been calculated. Benefits 4 hundred and fifty-one sufferers have been incorporated at admission for the ICU. At 6 months follow-up, 159 sufferers had died and 40 sufferers were lost to follow-up. When the basic overall health item was applied as an estimate of HRQOL, the area beneath the curve (AUC) for model A (0.719) was comparable with model B (0.721), and slightly far better in model C (0.760). The percentage of wrong predictions was lower in model C (survival 27 ; death 37 ) compared with model A (30 and 41 ). Related results were located when using the total SF-36. Conclusions This study shows that the pre-admission HRQOL measured with either the one-item basic overall health query or the full SF-36 are as great in predicting survival/mortality in ICU individuals because the APACHE II score and improves prediction slightly when combined. As the one-item common health query is conveniently and rapidly obtained, assessment of HRQOL ahead of admission for the ICU may well facilitate the decision process in figuring out which patients will benefit from ICU therapy.P492 Top quality of life following prolonged essential illness: insights from a qualitative approachP Ramsay Royal Infirmary of Edinburgh, UK Critical Care 2007, 11(Suppl 2):P492 (doi: 10.1186/cc565.