AlmiRNA(s)DovepressmiR1273p, miR-148b, miR376a, miR376c, miR4093p, miR652, miRsubmit your manuscript | www.dovepress.commiR133a, miR-148bmiRmiR-148b, miR376c, miR4093p, miRmiR-155, miRmiRmiRNotes: This is a representative sample of 20 recent research found on a PubMed query (breast cancer blood miRNA miR) that describe individual miRNAs or miRNA signatures getting potential application for early illness detection. Research with fewer than 20 BC situations have been excluded. While these signatures mostly reflect greater amounts of circulating miRNAs, some miRNAs are detected at reduced levels in blood samples of BC patients. Blood collection was performed just before surgery unless otherwise indicated. miRNAs shown in bold indicate a recurrent presence in at the very least 3 independent research. Abbreviations: BC, breast cancer; DCiS, ductal carcinoma in situ; eR, estrogen receptor; LN, lymph node status; miRNA, microRNA; qRTPCR, quantitative realtime polymerase chain reaction.Breast Cancer: Targets and Therapy 2015:DovepressDovepressmicroRNAs in breast cancerTable two miRNArelated threat loci related to BCGene locus MIR27A SNP rs895919 *C Comments Population AZD3759 biological activity Asians Caucasians Jewish BRCA2 carriers Caucasian Asians Caucasians Chinese (young) Chinese Asians Caucasians African Americans African Americans european Americans Chinese Chinese African Americans european Americans African Americans european Americans italian Caucasians Chinese Asians Caucasians Asians Asians Caucasians Chinese Asians Caucasians Chinese Asians Caucasians African Americans African Americans Korean italian and German Asians Caucasians Brazilian Caucasian Chinese and Korean Chinese Chinese African Americans european Americans Asians Caucasians African Americans european Americans African a0023781 Americans African Americans european Americans African Americans european Americans Asians Caucasians Clinical observation No danger ONO-4059 price association Protective dar.12324 elevated risk Decreased threat No threat association Decreased risk Decreased threat Decreased threat No risk association No risk association improved survival No threat association Decreased all round danger increased danger elevated threat No danger association enhanced general threat Decreased risk of eR+ BC No threat association earlier age of onset No threat association No threat association No risk association No risk association Decreased danger (C allele) No threat association No danger association No risk association No risk association No danger association No threat association No risk association No danger association Reduced danger Lowered threat Survival of HeR2+ instances No danger association Decreased risk No danger association Decreased danger Decreased threat Decreased danger increased risk elevated risk No risk association No threat association No threat association No risk association Decreased danger of eR- BC No threat association enhanced survival increased risk of eR- BC No risk association No risk association improved all round threat No danger association No risk association Reference 141 142 143 144 35 34 31 145 33 38 38 33 33 146 147 83 38 144 31 36 38 36 31 145 145 148 37 141 149 147 32 36 83 33 31 33 145 33 33rs895819 A/GpremiRNA premiRNA premiRNA premiRNAMIR34B cluster MIR100 MIR101-2 MIR106B MIR122A MIR146Ars4938723 T/C rs1834306 G/A rs1053872 C/G rs462480 A/C rs1527423 A/G rs17669 A/G rs2910164 G/C Primary transcript Major transcriptMIRrs2292832 T/GMIR185 MIR196A-rs2008591 C/T rs887205 A/G rs11614913 T/CMIR204 MIR206 MIR219 MIR331 MIRrs7861254 G rs6920648 A/G rs107822 G/A rs.AlmiRNA(s)DovepressmiR1273p, miR-148b, miR376a, miR376c, miR4093p, miR652, miRsubmit your manuscript | www.dovepress.commiR133a, miR-148bmiRmiR-148b, miR376c, miR4093p, miRmiR-155, miRmiRmiRNotes: That is a representative sample of 20 current research discovered on a PubMed query (breast cancer blood miRNA miR) that describe individual miRNAs or miRNA signatures getting potential application for early disease detection. Studies with fewer than 20 BC cases had been excluded. When these signatures mainly reflect higher amounts of circulating miRNAs, some miRNAs are detected at reduce levels in blood samples of BC patients. Blood collection was performed prior to surgery unless otherwise indicated. miRNAs shown in bold indicate a recurrent presence in at least 3 independent studies. Abbreviations: BC, breast cancer; DCiS, ductal carcinoma in situ; eR, estrogen receptor; LN, lymph node status; miRNA, microRNA; qRTPCR, quantitative realtime polymerase chain reaction.Breast Cancer: Targets and Therapy 2015:DovepressDovepressmicroRNAs in breast cancerTable two miRNArelated threat loci related to BCGene locus MIR27A SNP rs895919 *C Comments Population Asians Caucasians Jewish BRCA2 carriers Caucasian Asians Caucasians Chinese (young) Chinese Asians Caucasians African Americans African Americans european Americans Chinese Chinese African Americans european Americans African Americans european Americans italian Caucasians Chinese Asians Caucasians Asians Asians Caucasians Chinese Asians Caucasians Chinese Asians Caucasians African Americans African Americans Korean italian and German Asians Caucasians Brazilian Caucasian Chinese and Korean Chinese Chinese African Americans european Americans Asians Caucasians African Americans european Americans African a0023781 Americans African Americans european Americans African Americans european Americans Asians Caucasians Clinical observation No risk association Protective dar.12324 improved danger Decreased risk No danger association Decreased threat Decreased danger Decreased danger No risk association No risk association improved survival No threat association Decreased overall danger enhanced danger increased danger No danger association elevated overall risk Decreased danger of eR+ BC No danger association earlier age of onset No threat association No danger association No threat association No threat association Decreased threat (C allele) No risk association No danger association No danger association No threat association No threat association No risk association No danger association No risk association Lowered risk Decreased threat Survival of HeR2+ cases No risk association Decreased risk No threat association Decreased danger Decreased danger Decreased danger improved danger elevated danger No threat association No danger association No risk association No danger association Decreased danger of eR- BC No danger association elevated survival enhanced danger of eR- BC No risk association No threat association improved general threat No threat association No danger association Reference 141 142 143 144 35 34 31 145 33 38 38 33 33 146 147 83 38 144 31 36 38 36 31 145 145 148 37 141 149 147 32 36 83 33 31 33 145 33 33rs895819 A/GpremiRNA premiRNA premiRNA premiRNAMIR34B cluster MIR100 MIR101-2 MIR106B MIR122A MIR146Ars4938723 T/C rs1834306 G/A rs1053872 C/G rs462480 A/C rs1527423 A/G rs17669 A/G rs2910164 G/C Key transcript Primary transcriptMIRrs2292832 T/GMIR185 MIR196A-rs2008591 C/T rs887205 A/G rs11614913 T/CMIR204 MIR206 MIR219 MIR331 MIRrs7861254 G rs6920648 A/G rs107822 G/A rs.