Name :
Recombinant Human XTP3TPA Protein (His Tag)

Biological Activity :

Background :
DCTPP1 hydrolyzes deoxynucleoside triphosphates (dNTPs) to the corresponding nucleoside monophosphates. It has a strong preference for modified dCTP. DCTPP1’s activity is highest with 5-iodo-dCTP, followed by 5-bromo-dCTP, unmodified dCTP, 5-methyl-dCTP and 5-chloro-dCTP. DCTPP1 also hydrolyzes 2-chloro-dATP and 2-hydroxy-dATP with lower efficiency, and has even lower activity with unmodified dATP, dTTP and dUTP (in vitro). DCTPP1 does not hydrolyze ATP, UTP, ITP, GTP, dADP, dCDP or dGTP. It may protect DNA or RNA against the incorporation of non-canonical nucleotide triphosphates. DCTPP1 may also protect cells against inappropriate methylation of CpG islands by DNA methyltransferases.

Biological Activity :
Testing in progress

Expression Host :
Human

Source :
E. coli

Tag :

Protein Accession No. :
NP_077001.1

NCBI Gene ID :

Synonyms :

Synonyms :
dCTP pyrophosphatase 1

Amino Acid Sequence :

Molecular Weight :
The recombinant human XTP3TPA consists of 185 amino acids and predicts a molecular mass of 20.5 KDa. It migrates as an approximately 21 KDa band in SDS-PAGE under reducing conditions.

Purity :
> 90 % as determined by SDS-PAGE

State of Matter :

Product Concentration :

Storage and Stability :
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

Endotoxin Level :
Please contact us for more information.

Protein Construction :
A DNA sequence encoding the mature form of human XTP3TPA(NP_077001.1) (Met1-Thr170) was expressed with a polyhistidine tag at the N-terminus.

Buffer Solution :
Lyophilized from sterile 50mM Tris, 10% Glycerol, 100mM NaCl, pH 8.0.Please contact us for any concerns or special requirements. Normally 5 % – 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Please refer to the specific buffer information in the hardcopy of datasheet.

Shipping :
In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.

Redissolution :
A hardcopy of datasheet with reconstitution instructions is sent along with the products. Please refer to it for detailed information.

Synonyms :
CDA03 Protein, Human; RS21C6 Protein, Human; XTP3TPA Protein, Human XTP3TPA 背景信息 DCTPP1 hydrolyzes deoxynucleoside triphosphates (dNTPs) to the corresponding nucleoside monophosphates. It has a strong preference for modified dCTP. DCTPP1’s activity is highest with 5-iodo-dCTP, followed by 5-bromo-dCTP, unmodified dCTP, 5-methyl-dCTP and 5-chloro-dCTP. DCTPP1 also hydrolyzes 2-chloro-dATP and 2-hydroxy-dATP with lower efficiency, and has even lower activity with unmodified dATP, dTTP and dUTP (in vitro). DCTPP1 does not hydrolyze ATP, UTP, ITP, GTP, dADP, dCDP or dGTP. It may protect DNA or RNA against the incorporation of non-canonical nucleotide triphosphates. DCTPP1 may also protect cells against inappropriate methylation of CpG islands by DNA methyltransferases.

References & Citations :
Stelzl U. et al., 2005, Cell. 122 (6): 957-68. Strausberg RL. et al., 2003, Proc Natl Acad Sci. 99 (26): 16899-903. Moroz OV. et al., 2005, J Mol Biol. 347 (2): 243-55.

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