Archives October 2025

HA1 (H1N1) (A/Solomon Islands/3/2006) Recombinant Protein

Name :
HA1 (H1N1) (A/Solomon Islands/3/2006) Recombinant Protein

Biological Activity :
HA1 (H1N1) (A/Solomon Islands/3/2006) (ABU99069, 18 a.a. – 344 a.a.) partial recombinant protein with His tag expressed in 293 cells.Recombinant Human Protein,Recombinant Human Proteins,Human Recombinant Protein,Human Recombinant Proteins,HuPro

Tag :

Protein Accession No. :

Protein Accession No.URL :

Amino Acid Sequence :

Molecular Weight :

Storage and Stability :
Store at -20°C.Aliquot to avoid repeated freezing and thawing.

Host :
Human

Interspecies Antigen Sequence :

Preparation Method :
Mammalian cell (293) expression system

Purification :

Quality Control Testing :
SDS-PAGE Result

Storage Buffer :
In PBS

Applications :
SDS-PAGE,

Gene Name :

Gene Alias :

Gene Description :

Gene Summary :

Other Designations :

MedChemExpress (MCE) recombinant proteins include: cytokines, enzymes, growth factors, hormones, receptors, transcription factors, antibody fragments, etc. They are often essential for supporting cell growth, stimulating cell signaling pathways, triggering or inhibiting cell differentiation; and are useful tools for elucidating protein structure and function, understanding disease onset and progression, and validating pharmaceutical targets. At MedChemExpress (MCE), we strive to provide products with only the highest quality. Protein identity, purity and biological activity are assured by our robust quality control and assurance procedures.
Related category websites: https://www.medchemexpress.com/recombinant-proteins.html
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Human Osteomodulin Protein 2323

Product Name :
Human Osteomodulin Protein 2323

express system :
HEK293

Product tag :
C-His

Purity:
> 95% as determined by Tris-Bis PAGE

Background:
Osteomodulin (OMD) is a member of the small leucine-rich repeat proteoglycan family, which is involved in the organization of the extracellular matrix. OMD is located in bone tissue and is reportedly important for bone mineralization. Mechanistically, OMD could bind to BMP2 via its terminal leucine-rich repeats and formed complexes with BMP2 and its membrane receptors, thus promoting BMP/SMAD signal transduction. In addition, OMD was a putative target gene of SMAD4, which plays a pivotal role in this pathway.

Molecular Weight:
The protein has a predicted MW of 48.25 kDa. Due to glycosylation, the protein migrates to 50-70 kDa based on Tris-Bis PAGE result.

Available Size :
100 µg, 500 µg

Endotoxin:
Less than 1EU per μg by the LAL method.

Form :
Lyophilized

Storage Instructions :
Valid for 12 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

Storage buffer:
Shipped at ambient temperature.

Additional Information:
accession Q99983|express systemHEK293|product tagC-His|purity> 95% as determined by Tris-Bis PAGE|backgroundOsteomodulin (OMD) is a member of the small leucine-rich repeat proteoglycan family, which is involved in the organization of the extracellular matrix. OMD is located in bone tissue and is reportedly important for bone mineralization. Mechanistically, OMD could bind to BMP2 via its terminal leucine-rich repeats and formed complexes with BMP2 and its membrane receptors, thus promoting BMP/SMAD signal transduction. In addition, OMD was a putative target gene of SMAD4, which plays a pivotal role in this pathway.|molecular weightThe protein has a predicted MW of 48.25 kDa. Due to glycosylation, the protein migrates to 50-70 kDa based on Tris-Bis PAGE result.|available size100 g, 500 g|endotoxinLess than 1EU per g by the LAL method.|Human Osteomodulin Protein 2323proteinSize and concentration100, 500g and lyophilizedFormLyophilizedStorage InstructionsValid for 12 months from date of receipt when stored at -80C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.Storage bufferShipped at ambient temperature.Purity> 95% as determined by Tris-Bis PAGEtarget relevanceOsteomodulin (OMD) is a member of the small leucine-rich repeat proteoglycan family, which is involved in the organization of the extracellular matrix. OMD is located in bone tissue and is reportedly important for bone mineralization. Mechanistically, OMD could bind to BMP2 via its terminal leucine-rich repeats and formed complexes with BMP2 and its membrane receptors, thus promoting BMP/SMAD signal transduction. In addition, OMD was a putative target gene of SMAD4, which plays a pivotal role in this pathway.Protein namesOsteomodulin (Keratan sulfate proteoglycan osteomodulin) (KSPG osteomodulin) (Osteoadherin) (OSAD)Gene namesOMD,OMD SLRR2C UNQ190/PRO216Protein familySmall leucine-rich proteoglycan (SLRP) family, SLRP class II subfamilyMass9606DaFunctionMay be implicated in biomineralization processes. Has a function in binding of osteoblasts via the alpha(V)beta(3)-integrin.Subellular locationSecreted, extracellular space, extracellular matrix .TissuesBone specific.StructureBinds the alpha(V)beta(3)-integrin.Post-translational modificationGlycosylated; contains keratan sulfate.Target Relevance information above includes information from UniProt accession: Q99983The UniProt Consortium|

MedChemExpress (MCE) recombinant proteins include: cytokines, enzymes, growth factors, hormones, receptors, transcription factors, antibody fragments, etc. They are often essential for supporting cell growth, stimulating cell signaling pathways, triggering or inhibiting cell differentiation; and are useful tools for elucidating protein structure and function, understanding disease onset and progression, and validating pharmaceutical targets. At MedChemExpress (MCE), we strive to provide products with only the highest quality. Protein identity, purity and biological activity are assured by our robust quality control and assurance procedures.
Related category websites: https://www.medchemexpress.com/recombinant-proteins.html
305834-79-1 site 57-64-7 References PMID:31194459 MedChemExpress (MCE) offers a wide range of high-quality research chemicals and biochemicals (novel life-science reagents, reference compounds and natural compounds) for scientific use. We have professionally experienced and friendly staff to meet your needs. We are a competent and trustworthy partner for your research and scientific projects.Related websites: https://www.medchemexpress.com

Human IL-17F Protein, His Tag (MALS verified)

Name :
Human IL-17F Protein, His Tag (MALS verified)

Background :
Interleukin-17F (IL17F) is also known as Interleukin-24 (IL24), Cytokine ML-1, is a secreted disulfide-linked homodimer which belongs to the IL-17 family. There are at least six members of the IL-17 family in humans and in mice: IL-17A, IL-17B, IL-17C, IL-17D, IL-17E (also called IL-25) and IL-17F (also called IL-24). IL-17 represents a family of structurally related cytokines that share a highly conserved C-terminal region but differ from one another in their N-terminal regions and in their distinct biological roles. IL-17F / IL-24 is expressed in activated, but not resting, CD4+ T-cells and activated monocytes. IL17F / Interleukin-24 stimulates the production of other cytokines such as IL-6, IL-8 and granulocyte colony-stimulating factor, and can regulate cartilage matrix turnover. IL17F / IL-24 stimulates PBMC and T-cell proliferation and Inhibits angiogenesis. Defects in IL17F are the cause of familial candidiasis type 6 (CANDF6).

Biological Activity :
Immobilized Human IL-17F, His Tag (Cat. No. ILF-H5244) at 5 μg/mL (100 μL/well) can bind Human IL-17 RA Protein, Fc Tag (Cat. No. ILA-H5257) with a linear range of 2-78 ng/mL (QC tested).

Species :

Source :
Human IL-17F, His Tag (ILF-H5244) is expressed from human 293 cells (HEK293). It contains AA Arg 31 – Gln 163 (Accession # Q96PD4-1 ).

Tag :

Synonyms :
(Synonym)IL-17F,Interleukin-17F,Cytokine ML-1

Purity :
(Purity)>95% as determined by SDS-PAGE.

Storage and Stability :
For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Endotoxin Level :
(Endotoxin)Less than 1.0 EU per μg by the LAL method.

Formulation :
Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

Protein Structure :
This protein carries a polyhistidine tag at the N-terminus.

Refactoring Approach :
Please see Certificate of Analysis for specific instructions.

Protein Labeling :

MedChemExpress (MCE) recombinant proteins include: cytokines, enzymes, growth factors, hormones, receptors, transcription factors, antibody fragments, etc. They are often essential for supporting cell growth, stimulating cell signaling pathways, triggering or inhibiting cell differentiation; and are useful tools for elucidating protein structure and function, understanding disease onset and progression, and validating pharmaceutical targets. At MedChemExpress (MCE), we strive to provide products with only the highest quality. Protein identity, purity and biological activity are assured by our robust quality control and assurance procedures.
Related category websites: https://www.medchemexpress.com/recombinant-proteins.html
4,4′-Trimethylenedipyridine Cancer Pentamidine Purity & Documentation PMID:35034724 MedChemExpress (MCE) offers a wide range of high-quality research chemicals and biochemicals (novel life-science reagents, reference compounds and natural compounds) for scientific use. We have professionally experienced and friendly staff to meet your needs. We are a competent and trustworthy partner for your research and scientific projects.Related websites: https://www.medchemexpress.com

NEK6 (Human) Recombinant Protein

Name :
NEK6 (Human) Recombinant Protein

Biological Activity :
Human NEK6 (NM_014397, 8 a.a. – 313a.a.) partial recombinant protein with GST-His tag expressed in Sf9 cells.Bioactive Protein,Bioactive Proteins,Bioactive,Active,Functional Protein,Functional Proteins

Tag :
Result of activity analysis

Protein Accession No. :
NM_014397

Protein Accession No.URL :
https://www.ncbi.nlm.nih.gov/gene?cmd=Retrieve&dopt=Graphics&list_uids=10783

Amino Acid Sequence :

Molecular Weight :
68.041

Storage and Stability :
Store at -80°C.Aliquot to avoid repeated freezing and thawing

Host :
insect

Interspecies Antigen Sequence :

Preparation Method :
Insect cell (Sf9) expression system

Purification :
One-step affinity purification using_x005f
_x005f
GSH-agarose

Quality Control Testing :
2 ug/lane SDS-PAGE Stained with Coomassie Blue

Storage Buffer :
In 50 mM Tris-HCl, 100 mM NaCl, pH 8.0. (5 mM DTT, 15 mM reduced glutathione, 20% glycerol)

Applications :
Functional Study, SDS-PAGE,

Gene Name :
NEK6

Gene Alias :
SID6-1512

Gene Description :
NIMA (never in mitosis gene a)-related kinase 6

Gene Summary :
The Aspergillus nidulans ‘never in mitosis A’ (NIMA) gene encodes a serine/threonine kinase that controls initiation of mitosis. NIMA-related kinases (NEKs) are a group of protein kinases that are homologous to NIMA. Evidence suggests that NEKs perform functions similar to those of NIMA.[supplied by OMIM

Other Designations :
OTTHUMP00000022095|OTTHUMP00000022097|putative serine-threonine protein kinase

MedChemExpress (MCE) recombinant proteins include: cytokines, enzymes, growth factors, hormones, receptors, transcription factors, antibody fragments, etc. They are often essential for supporting cell growth, stimulating cell signaling pathways, triggering or inhibiting cell differentiation; and are useful tools for elucidating protein structure and function, understanding disease onset and progression, and validating pharmaceutical targets. At MedChemExpress (MCE), we strive to provide products with only the highest quality. Protein identity, purity and biological activity are assured by our robust quality control and assurance procedures.
Related category websites: https://www.medchemexpress.com/recombinant-proteins.html
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Human Integrin alpha 10 beta 1 (ITGA10&ITGB1) Heterodimer Protein 5076

Product Name :
Human Integrin alpha 10 beta 1 (ITGA10&ITGB1) Heterodimer Protein 5076

express system :
HEK293

Product tag :
C-His

Purity:
> 90% as determined by Tris-Bis PAGE

Background:
Alpha 10 beta 1 is currently known as four collagen-binding I domain-containing integrins, the others are namely alpha 1 beta 1, alpha 2 beta 1 and alpha 11 beta 1. α10β1 is likely to be expressed only by a subset of fibroblasts.

Molecular Weight:
The protein has a predicted MW of 125.60 kDa (ITGA10) & 83.2 kDa (ITGB1). Due to glycosylation, the protein migrates to 140-160 kDa (ITGA10) and 100-130 kDa (ITGB1) based on Tris-Bis PAGE result.

Available Size :
100 µg, 500 µg

Endotoxin:
Less than 1EU per μg by the LAL method.

Form :
Lyophilized

Storage Instructions :
Valid for 12 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

Storage buffer:
Shipped at ambient temperature.

Additional Information:
accession O75578(ITGA10)&P05556(ITGB1)|express systemHEK293|product tagC-His|purity> 90% as determined by Tris-Bis PAGE|backgroundAlpha 10 beta 1 is currently known as four collagen-binding I domain-containing integrins, the others are namely alpha 1 beta 1, alpha 2 beta 1 and alpha 11 beta 1. 101 is likely to be expressed only by a subset of fibroblasts.|molecular weightThe protein has a predicted MW of 125.60 kDa (ITGA10) & 83.2 kDa (ITGB1). Due to glycosylation, the protein migrates to 140-160 kDa (ITGA10) and 100-130 kDa (ITGB1) based on Tris-Bis PAGE result.|available size100 g, 500 g|endotoxinLess than 1EU per g by the LAL method.|Human Integrin alpha 10 beta 1 (ITGA10&ITGB1) Heterodimer Protein 5076proteinSize and concentration100, 500g and lyophilizedFormLyophilizedStorage InstructionsValid for 12 months from date of receipt when stored at -80C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.Storage bufferShipped at ambient temperature.Purity> 95% as determined by Tris-Bis PAGEtarget relevanceAlpha 10 beta 1 is currently known as four collagen-binding I domain-containing integrins, the others are namely alpha 1 beta 1, alpha 2 beta 1 and alpha 11 beta 1. 101 is likely to be expressed only by a subset offibroblasts.Protein namesIntegrin alpha-10Gene namesITGA10,ITGA10 UNQ468/PRO827Protein familyIntegrin alpha chain familyMass127602DaFunctionIntegrin alpha-10/beta-1 is a receptor for collagen.Subellular locationMembrane; Single-pass type I membrane protein.TissuesWidely expressed with highest expression in muscle and heart. Found in articular cartilage.StructureHeterodimer of an alpha and a beta subunit. Alpha-10 associates with beta-1.DomainThe integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo proTarget Relevance information above includes information from UniProt accession: O75578The UniProt Consortium|

MedChemExpress (MCE) recombinant proteins include: cytokines, enzymes, growth factors, hormones, receptors, transcription factors, antibody fragments, etc. They are often essential for supporting cell growth, stimulating cell signaling pathways, triggering or inhibiting cell differentiation; and are useful tools for elucidating protein structure and function, understanding disease onset and progression, and validating pharmaceutical targets. At MedChemExpress (MCE), we strive to provide products with only the highest quality. Protein identity, purity and biological activity are assured by our robust quality control and assurance procedures.
Related category websites: https://www.medchemexpress.com/recombinant-proteins.html
1903008-80-9 Formula 1309573-60-1 Biological Activity PMID:29939674 MedChemExpress (MCE) offers a wide range of high-quality research chemicals and biochemicals (novel life-science reagents, reference compounds and natural compounds) for scientific use. We have professionally experienced and friendly staff to meet your needs. We are a competent and trustworthy partner for your research and scientific projects.Related websites: https://www.medchemexpress.com

Human CD27 Ligand / CD70 Protein, Fc Tag, active trimer (MALS verified)

Name :
Human CD27 Ligand / CD70 Protein, Fc Tag, active trimer (MALS verified)

Background :
Cluster of Differentiation 70 (CD70) is also known as CD27 ligand (CD27L / CD27LG), TNFSF7, TNFSF7G, is a type II transmembrane glycoprotein belonging to the TNF superfamily (TNFSF) and is a surface antigen found on activated T-and B-lymphocytes and mature dendritic cells. Binding of CD70 to its receptor CD27 induces in priming, effector functions, differentiation and memory formation of T-cells, and thus is invloved in the biological processes including T-cell activation, the proliferation of costimulated T-cells, as well as the generation of cytolytic T-cells. CD70 on T cells provides costimulatory signals that are required for T cell proliferation, clonal expansion and the promotion of effector T cell formation. CD70 on mouse B cell has been shown to inhibit terminal differentiation of activated B cells into plasma cells and enhances commitment to memory B cell responses. CD70 induces proliferation and IFNγ production, on NK cells.

Biological Activity :
Immobilized Human CD27, His Tag (Cat. No. CD7-H522b) at 2 μg/mL (100 μL/well) can bind Human CD27 Ligand Protein, Fc Tag (Cat. No. CDL-H5266) with a linear range of 0.2-25 ng/mL (QC tested).

Species :

Source :
Human CD27 Ligand Protein, Fc Tag (CDL-H5266) is expressed from human 293 cells (HEK293). It contains AA Ser 52 – Pro 193 (Accession # P32970-1 ) trimer Design.

Tag :

Synonyms :
(Synonym)CD70,CD27LG,TNFSF7,TNFSF7G,CD27L

Purity :
(Purity)>95% as determined by SDS-PAGE.

Storage and Stability :
For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Endotoxin Level :
(Endotoxin)Less than 1.0 EU per μg by the LAL method.

Formulation :
Lyophilized from 0.22 μm filtered solution in Tris, Glycine and NaCl, pH7.5 with trehalose as protectant.

Protein Structure :
This protein carries a human IgG1 Fc tag at the N-terminus.

Refactoring Approach :
Please see Certificate of Analysis for specific instructions.

Protein Labeling :

MedChemExpress (MCE) recombinant proteins include: cytokines, enzymes, growth factors, hormones, receptors, transcription factors, antibody fragments, etc. They are often essential for supporting cell growth, stimulating cell signaling pathways, triggering or inhibiting cell differentiation; and are useful tools for elucidating protein structure and function, understanding disease onset and progression, and validating pharmaceutical targets. At MedChemExpress (MCE), we strive to provide products with only the highest quality. Protein identity, purity and biological activity are assured by our robust quality control and assurance procedures.
Related category websites: https://www.medchemexpress.com/recombinant-proteins.html
Enterokinase ProteinPurity & Documentation CBX1 Antibody Purity PMID:34866245 MedChemExpress (MCE) offers a wide range of high-quality research chemicals and biochemicals (novel life-science reagents, reference compounds and natural compounds) for scientific use. We have professionally experienced and friendly staff to meet your needs. We are a competent and trustworthy partner for your research and scientific projects.Related websites: https://www.medchemexpress.com

VAT1 (Human) Recombinant Protein

Name :
VAT1 (Human) Recombinant Protein

Biological Activity :
Human VAT1 (NP_006364, 1 a.a. – 393 a.a.) full-length recombinant protein with His tag expressed in Escherichia coli.Full-Length Protein,Full-Length Proteins,Full-Length,Full Length,FullLength

Tag :

Protein Accession No. :
NP_006364

Protein Accession No.URL :
https://www.ncbi.nlm.nih.gov/gene?cmd=Retrieve&dopt=Graphics&list_uids=10493

Amino Acid Sequence :
MGSSHHHHHHSSGLVPRGSHMSDEREVAEAATGEDASSPPPKTEAASDPQHPAASEGAAAAAASPPLLRCLVLTGFGGYDKVKLQSRPAAPPAPGPGQLTLRLRACGLNFADLMARQGLYDRLPPLPVTPGMEGAGVVIAVGEGVSDRKAGDRVMVLNRSGMWQEEVTVPSVQTFLIPEAMTFEEAAALLVNYITAYMVLFDFGNLQPGHSVLVHMAAGGVGMAAVQLCRTVENVTVFGTASASKHEALKENGVTHPIDYHTTDYVDEIKKISPKGVDIVMDPLGGSDTAKGYNLLKPMGKVVTYGMANLLTGPKRNLMALARTWWNQFSVTALQLLQANRAVCGFHLGYLDGEVELVSGVVARLLALYNQGHIKPHIDSVWPFEKVADAMKQMQEKKNVGKVLLVPGPEKEN

Molecular Weight :
44.1

Storage and Stability :
Store at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20°C to -80°C.Aliquot to avoid repeated freezing and thawing.

Host :
Escherichia coli

Interspecies Antigen Sequence :

Preparation Method :
Escherichia coli expression system

Purification :

Quality Control Testing :
15% SDS-PAGE Stained with Coomassie Blue

Storage Buffer :
In 20 mM Tris-HCl buffer, 100 mM NaCl, pH 8.0 (10% glycerol, 1 mM DTT).

Applications :
Functional Study, SDS-PAGE,

Gene Name :
VAT1

Gene Alias :
FLJ20230, VATI

Gene Description :
vesicle amine transport protein 1 homolog (T. californica)

Gene Summary :
Synaptic vesicles are responsible for regulating the storage and release of neurotransmitters in the nerve terminal. The protein encoded by this gene is an abundant integral membrane protein of cholinergic synaptic vesicles and is thought to be involved in vesicular transport. It belongs to the quinone oxidoreductase subfamily of zinc-containing alcohol dehydrogenase proteins. [provided by RefSeq

Other Designations :
membrane protein of cholinergic synaptic vesicles|synaptic vesicle membrane protein VAT-1 homolog|vesicle amine transport protein 1

MedChemExpress (MCE) recombinant proteins include: cytokines, enzymes, growth factors, hormones, receptors, transcription factors, antibody fragments, etc. They are often essential for supporting cell growth, stimulating cell signaling pathways, triggering or inhibiting cell differentiation; and are useful tools for elucidating protein structure and function, understanding disease onset and progression, and validating pharmaceutical targets. At MedChemExpress (MCE), we strive to provide products with only the highest quality. Protein identity, purity and biological activity are assured by our robust quality control and assurance procedures.
Related category websites: https://www.medchemexpress.com/recombinant-proteins.html
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Human HVEM/TNFRSF14 Protein 4355

Product Name :
Human HVEM/TNFRSF14 Protein 4355

express system :
HEK293

Product tag :
C-His

Purity:
> 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC

Background:
Herpesvirus entry mediator (HVEM), also known as tumor necrosis factor receptor superfamily member 14 (TNFRSF14), is a human cell surface receptor of the TNF-receptor superfamily. Two TNF superfamily ligands lymphotoxin α (TNF-β) and LIGHT (TNFSF14) are identified as cellular ligands for HVEM and initiate the positive signaling.

Molecular Weight:
The protein has a predicted MW of 18.5 kDa. Due to glycosylation, the protein migrates to 32-48 kDa based on Tris-Bis PAGE result.

Available Size :
100 µg, 500 µg

Endotoxin:
Less than 1EU per μg by the LAL method.

Form :
Lyophilized

Storage Instructions :
Valid for 12 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

Storage buffer:
Shipped at ambient temperature.

Additional Information:
accession Q92956|express systemHEK293|product tagC-His|purity> 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC|backgroundHerpesvirus entry mediator (HVEM), also known as tumor necrosis factor receptor superfamily member 14 (TNFRSF14), is a human cell surface receptor of the TNF-receptor superfamily. Two TNF superfamily ligands lymphotoxin (TNF-) and LIGHT (TNFSF14) are identified as cellular ligands for HVEM and initiate the positive signaling.|molecular weightThe protein has a predicted MW of 18.5 kDa. Due to glycosylation, the protein migrates to 32-48 kDa based on Tris-Bis PAGE result.|available size100 g, 500 g|endotoxinLess than 1EU per g by the LAL method.|Human HVEM/TNFRSF14 Protein 4355proteinSize and concentration100, 500g and lyophilizedFormLyophilizedStorage InstructionsValid for 12 months from date of receipt when stored at -80C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.Storage bufferShipped at ambient temperature.Purity> 95% as determined by Tris-Bis PAGEtarget relevanceHerpesvirus entry mediator (HVEM), also known as tumor necrosis factor receptor superfamily member 14 (TNFRSF14), is a human cell surface receptor of the TNF-receptor superfamily. Two TNF superfamily ligands lymphotoxin (TNF-) and LIGHT (TNFSF14) are identified as cellular ligands for HVEM and initiate the positive signaling.Protein namesTumor necrosis factor receptor superfamily member 14 (Herpes virus entry mediator A) (Herpesvirus entry mediator A) (HveA) (Tumor necrosis factor receptor-like 2) (TR2) (CD antigen CD270)Gene namesTNFRSF14,TNFRSF14 HVEA HVEM UNQ329/PRO509Protein familyTumor necrosis factor receptor superfamilyMass9606DaFunctionReceptor for four distinct ligands: The TNF superfamily members TNFSF14/LIGHT and homotrimeric LTA/lymphotoxin-alpha and the immunoglobulin superfamily members BTLA and CD160, altogether defining a complex stimulatory and inhibitory signaling network (PubMed:10754304, PubMed:18193050, PubMed:23761635, PubMed:9462508). Signals via the TRAF2-TRAF3 E3 ligase pathway to promote immune cell survival and differentiation (PubMed:19915044, PubMed:9153189, PubMed:9162022). Participates in bidirectional cell-cell contact signaling between antigen presenting cells and lymphocytes. In response to ligation of TNFSF14/LIGHT, delivers costimulatory signals to T cells, promoting cell proliferation and effector functions (PubMed:10754304). Interacts with CD160 on NK cells, enhancing IFNG production and anti-tumor immune response (PubMed:23761635). In the context of bacterial infection, acts as a signaling receptor on epithelial cells for CD160 from intraepithelial lymphocytes, triggering the production of antimicrobial proteins and pro-inflammatory cytokines (By similarity). Upon binding to CD160 on activated CD4+ T cells, down-regulates CD28 costimulatory signaling, restricting memory and alloantigen-specific immune response (PubMed:18193050). May interact in cis (on the same cell) or in trans (on other cells) with BTLA (By similarity) (PubMed:19915044). In cis interactions, appears to play an immune regulatory role inhibiting in trans interactions in naive T cells to maintain a resting state. In trans interactions, can predominate during adaptive immune response to provide survival signals to effector T cells (By similarity) (PubMed:19915044).; (Microbial infection) Acts as a receptor for Herpes simplex virus 1/HHV-1.; (Microbial infection) Acts as a receptor for Herpes simplex virus 2/HHV-2.Subellular locationCell membrane ; Single-pass type I membrane protein .TissuesWidely expressed, with the highest expression in lung, spleen and thymus. Expressed in a subpopulation of B cells and monocytes (PubMed:18193050). Expressed in naive T cells (PubMed:19915044).StructureInteracts with TRAF2, TRAF3 and TRAF5 (PubMed:9153189, PubMed:9162022). Interacts (via CRD1/TNFR-Cys 1) with CD160; this interaction is direct (PubMed:18193050, PubMed:23761635). Interacts with LTA and TNFSF14 (PubMed:9462508). Interacts (via CRD1/TNFR-Cys 1) in cis and trans with BTLA; the cis interactions inhibits the trans interactions (PubMed:16169851, PubMed:19915044).; (Microbial infection) Interacts with herpes simplex virus 1/HHV-1 envelope glycoprotein D.; (Microbial infection) Interacts with herpes simplex virus 2/HHV-2 envelope glycoprotein D.Post-translational modificationN-glycosylated.DomainThTarget Relevance information above includes information from UniProt accession: Q92956The UniProt Consortium|

MedChemExpress (MCE) recombinant proteins include: cytokines, enzymes, growth factors, hormones, receptors, transcription factors, antibody fragments, etc. They are often essential for supporting cell growth, stimulating cell signaling pathways, triggering or inhibiting cell differentiation; and are useful tools for elucidating protein structure and function, understanding disease onset and progression, and validating pharmaceutical targets. At MedChemExpress (MCE), we strive to provide products with only the highest quality. Protein identity, purity and biological activity are assured by our robust quality control and assurance procedures.
Related category websites: https://www.medchemexpress.com/recombinant-proteins.html
1115-70-4 SMILES 155270-99-8 Description PMID:30725978 MedChemExpress (MCE) offers a wide range of high-quality research chemicals and biochemicals (novel life-science reagents, reference compounds and natural compounds) for scientific use. We have professionally experienced and friendly staff to meet your needs. We are a competent and trustworthy partner for your research and scientific projects.Related websites: https://www.medchemexpress.com

Human Flt-3 Ligand Protein, premium grade

Name :
Human Flt-3 Ligand Protein, premium grade

Background :
FMS-like tyrosine kinase 3 ligand (Flt-3 Ligand) is also known as FL, Flt3L and FLT3LG, is an α-helical cytokine that promotes the differentiation of multiple hematopoietic cell lineages. FLT3LG is expressed as a noncovalentlylinked dimer by T cells and bone marrow and thymic fibroblasts. Each 36 kDa chain carries approximately 12 kDa of N- and O- linked carbohydrates. FLT3LG is structurally homologous to stem cell factor (SCF) and colony stimulating facor 1 (CSF-1). FLT3LG acts as a growth factor that increases the number of immune cells by activating the hematopoietic progenitors. It also induces the mobilization of the hematopoietic progenitors and stem cells in vivo which may help the system to kill cancer cells. FLT3LG induces the expansion of monocytes and immature dendritic cells as well as early B cell lineage differentiation. FLT3LG cooperates with IL2, IL6, IL7, and IL15 to induce NK cell development and with IL3, IL7 and IL11 to induce terminal B cell maturation. Animal studies also show FLT3LG to reduce the severity of experimentally induced allergic inflammation. FLT3LG is crucial for steady-state pDC and cDC development. A lack of FLT3L results in low levels of DCs.

Biological Activity :
Immobilized Human Flt-3 Ligand, premium grade (Cat. No. FLL-H5218) at 1 μg/mL (100 μL/well) can bind Human Flt-3, Fc Tag (Cat. No. FL3-H5258) with a linear range of 0.1-2 ng/mL (QC tested).

Species :

Source :
Human Flt-3 Ligand, premium grade (FLL-H5218) is expressed from human 293 cells (HEK293). It contains AA Thr 27 – Pro 185 (Accession # P49771-1 ).

Tag :

Synonyms :
(Synonym)FLT3LG,FL,FLT3L,Flt3 ligand

Purity :
(Purity)>95% as determined by SDS-PAGE.

Storage and Stability :
For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Endotoxin Level :
(Endotoxin)Less than 0.01 EU per μg by the LAL method.

Formulation :
Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

Protein Structure :
This protein carries no “tag”.

Refactoring Approach :
Please see Certificate of Analysis for specific instructions.

Protein Labeling :

MedChemExpress (MCE) recombinant proteins include: cytokines, enzymes, growth factors, hormones, receptors, transcription factors, antibody fragments, etc. They are often essential for supporting cell growth, stimulating cell signaling pathways, triggering or inhibiting cell differentiation; and are useful tools for elucidating protein structure and function, understanding disease onset and progression, and validating pharmaceutical targets. At MedChemExpress (MCE), we strive to provide products with only the highest quality. Protein identity, purity and biological activity are assured by our robust quality control and assurance procedures.
Related category websites: https://www.medchemexpress.com/recombinant-proteins.html
Esaxerenone web CD172G Antibody site PMID:35046485 MedChemExpress (MCE) offers a wide range of high-quality research chemicals and biochemicals (novel life-science reagents, reference compounds and natural compounds) for scientific use. We have professionally experienced and friendly staff to meet your needs. We are a competent and trustworthy partner for your research and scientific projects.Related websites: https://www.medchemexpress.com

Rabbit TIGIT Protein, Fc Tag

Name :
Rabbit TIGIT Protein, Fc Tag

Background :
T-cell immunoreceptor with Ig and ITIM domains (TIGIT) is also known as V-set and immunoglobulin domain-containing protein 9 (VSIG9), V-set and transmembrane domain-containing protein 3 (VSTM3),which belongs to single-pass type I membrane protein containing an immunoglobulin variable domain, a transmembrane domain and an immunoreceptor tyrosine-based inhibitory motif (ITIM). TIGIT is expressed at low levels on peripheral memory and regulatory CD4+ T-cells and NK cells and is up-regulated following activation of these cells (at protein level). TIGIT binds with high affinity to the poliovirus receptor (PVR) which causes increased secretion of IL10 and decreased secretion of IL12B and suppresses T-cell activation by promoting the generation of mature immunoregulatory dendritic cells.

Biological Activity :
Immobilized Human Nectin-2, His Tag (Cat. No. PV2-H52E2) at 5 μg/mL (100 μL/well) can bind Rabbit TIGIT, Fc Tag (Cat. No. TIT-R5259) with a linear range of 5-78 ng/mL (QC tested).

Species :

Source :
Rabbit TIGIT, Fc Tag (TIT-R5259) is expressed from human 293 cells (HEK293). It contains AA Ala 16 – Pro 142 (Accession # G1SLC1).

Tag :

Synonyms :
(Synonym)TIGIT,VSIG9,VSTM3

Purity :
(Purity)>95% as determined by SDS-PAGE.

Storage and Stability :
For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Endotoxin Level :
(Endotoxin)Less than 1.0 EU per μg by the LAL method.

Formulation :
Lyophilized from 0.22 μm filtered solution in Tris with Glycine, Arginine and NaCl, pH7.5. Normally trehalose is added as protectant before lyophilization.

Protein Structure :

Refactoring Approach :
Please see Certificate of Analysis for specific instructions.

Protein Labeling :

MedChemExpress (MCE) recombinant proteins include: cytokines, enzymes, growth factors, hormones, receptors, transcription factors, antibody fragments, etc. They are often essential for supporting cell growth, stimulating cell signaling pathways, triggering or inhibiting cell differentiation; and are useful tools for elucidating protein structure and function, understanding disease onset and progression, and validating pharmaceutical targets. At MedChemExpress (MCE), we strive to provide products with only the highest quality. Protein identity, purity and biological activity are assured by our robust quality control and assurance procedures.
Related category websites: https://www.medchemexpress.com/recombinant-proteins.html
C18-Ceramide In Vitro Napsin A Antibody site PMID:35021253 MedChemExpress (MCE) offers a wide range of high-quality research chemicals and biochemicals (novel life-science reagents, reference compounds and natural compounds) for scientific use. We have professionally experienced and friendly staff to meet your needs. We are a competent and trustworthy partner for your research and scientific projects.Related websites: https://www.medchemexpress.com